De Novo Design of Inhibitors of DNA Methyltransferase 1: A Critical Comparison of Ligand- and Structure-Based Approaches.

Designing and developing inhibitors against the epigenetic target DNA methyltransferase (DNMT) is an attractive strategy in epigenetic drug discovery. DNMT1 is one of the epigenetic enzymes with significant clinical relevance. Structure-based de novo design is a drug discovery strategy that was used in combination with similarity searching to identify a novel DNMT inhibitor with a novel chemical scaffold and warrants further exploration. This study aimed to continue exploring the potential of de novo design to build epigenetic-focused libraries targeted toward DNMT1. Herein, we report the results of an in-depth and critical comparison of ligand- and structure-based de novo design of screening libraries focused on DNMT1. The newly designed chemical libraries focused on DNMT1 are freely available on GitHub.

Desarrollo del repositorio de recursos educativos abiertos para la Universidad Virtual de Salud de Santiago de Cuba

La utilización de herramientas tecnológicas en la docencia condiciona el desarrollo de nuevas destrezas intelectuales en los estudiantes, lo que les facilita la aplicación de estrategias de investigación, mejora sus capacidades de una forma integral, les ayuda a enfrentar las dificultades y exigencias del mundo y les permite adquirir un aprendizaje más significativo para poder desenvolverse en el ámbito socioeducativo. Con vistas a cumplir lo anterior, se desarrolló un repositorio institucional de recursos educativos abiertos para la Universidad Virtual de Salud, a partir del empleo de herramientas tecnológicas libres y de código abierto que permiten la estandarización e interoperabilidad entre cada uno de los repositorios establecidos en el Sistema Nacional de Salud, con lo cual se garantizará una lógica de organización académica.

The use of digital technologies in teaching determines the development of new intellectual skills in students, which facilitates the application of investigation strategies, improves their capabilities in an integral way, helps them face the difficulties and demands of the current world and allows them to acquire more significant learning to have a good performance in the socio-educational environment. With a view to fulfilling the above, an institutional repository of open educational resources was developed for the Virtual Health University, based on the use of free and open-source technology tools that allow the standardization and interoperability among each of the repositories established in the National Health System, which will guarantee logic of academic organization.

Evaluación de la gestión de calidad en la red de bibliotecas médicas de Villa Clara / Evaluation of quality management in Villa Clara medical library network

La calidad es una exigencia vigente a nivel mundial en el área de la educación, a su vez constituye un indicador fundamental para las instituciones educativas, sujetas a proporcionar un servicio de excelencia. Por ello resulta necesario evaluar la gestión de calidad en las bibliotecas médicas de Villa Clara, de manera tal que se contribuya al mejoramiento de su funcionamiento y lograr un mayor nivel de satisfacción de las necesidades informativas de sus usuarios. Se tomaron como referentes teóricos el modelo de evaluación de bibliotecas universitarias cubanas, y los documentos normativos y teórico-metodológicos del Centro Nacional de Información sobre la temática.

Quality is a worldwide requirement in the education area, and at the same time it is a fundamental indicator for educational institutions which are subjected to provide a service of excellence. For this reason, evaluating the quality management of medical libraries in Villa Clara is a necessity, in order to contribute to the improvement of their functioning and to achieve a higher level of satisfaction of their users' information needs. The evaluation model for Cuban university libraries and the normative, theoretical and methodological documents of the National Information Center of Medical Sciences regarding this subject were taken as theoretical references.

Uso de la Biblioteca Virtual de Salud de Cuba en Villa Clara / Use of the Cuban Virtual Health Library in Villa Clara

En la actualidad la capacidad de distinguir cuáles son las fuentes que brindan una información confiable es la herramienta más importante para los investigadores. Por tanto, es necesario profundizar en el uso de fuentes de información veraz y actualizada, y la importancia de evaluarlas. Esta problemática toma mayor fuerza en el área de la salud, por lo que las instituciones en cuestión, se han proyectado en este tipo de estudio. Tal es el caso del Centro Provincial de Información de Ciencias Médicas de Villa Clara, que se propuso evaluar el uso de la Biblioteca Virtual de Salud de Cuba por los bibliotecarios de la red de bibliotecas médicas de la provincia, cuyo objetivo fundamental es satisfacer las necesidades de sus usuarios.

Currently, the ability to distinguish which sources provide reliable information is the most important tool for researchers. Therefore, it is necessary to deepen the use of truthful and updated information sources, and the importance of evaluating them. This problem takes greater importance in the health area, that is why the institutions in question have been projected in this type of study. Such is the case of the Provincial Information Center for Medical Sciences from Villa Clara, which proposed to evaluate the use of the Cuban Virtual Health Library by the librarians of the network of medical libraries in the province, whose fundamental objective is to satisfy the needs of its users.

Design of a multi-target focused library for antidiabetic targets using a comprehensive set of chemical transformation rules.

Virtual small molecule libraries are valuable resources for identifying bioactive compounds in virtual screening campaigns and improving the quality of libraries in terms of physicochemical properties, complexity, and structural diversity. In this context, the computational-aided design of libraries focused against antidiabetic targets can provide novel alternatives for treating type II diabetes mellitus (T2DM). In this work, we integrated the information generated to date on compounds with antidiabetic activity, advances in computational methods, and knowledge of chemical transformations available in the literature to design multi-target compound libraries focused on T2DM. We evaluated the novelty and diversity of the newly generated library by comparing it with antidiabetic compounds approved for clinical use, natural products, and multi-target compounds tested in vivo in experimental antidiabetic models. The designed libraries are freely available and are a valuable starting point for drug design, chemical synthesis, and biological evaluation or further computational filtering. Also, the compendium of 280 transformation rules identified in a medicinal chemistry context is made available in the linear notation SMIRKS for use in other chemical library enumeration or hit optimization approaches.

In silico identification of D449-0032 compound as a putative SARS-CoV-2 Mpro inhibitor.

The SARS-CoV-2 pandemic originated the urgency in developing therapeutic resources for the treatment of COVID-19. Despite the current availability of vaccines and some antivirals, the occurence of severe cases of the disease and the risk of the emergence of new virus variants still motivate research in this field. In this context, this study aimed at the computational prospection of likely inhibitors of the main protease (Mpro) of SARS-CoV-2 since inhibiting this enzyme leads to disruption of the viral replication process. The virtual screening of the antiviral libraries Asinex, ChemDiv, and Enamine targeting SARS-CoV-2 Mpro was performed, indicating the D449-0032 compound as a promising inhibitor. Molecular dynamics simulations showed the stability of the protein-ligand complex and in silico predictions of toxicity and pharmacokinetic parameters indicated the probable drug-like behavior of the compound. In vitro and in vivo studies are essential to confirm the Mpro inhibition by the D449-0032.Communicated by Ramaswamy H. Sarma.

Diseño e implementación de la biblioteca virtual de la Facultad de Ciencias Médicas de Bayamo

Las páginas web constituyen un medio facilitador del conocimiento. El trabajo se realizó con el objetivo de diseñar e implementar una biblioteca virtual para favorecer el proceso de gestión de la información del Departamento de Información Científica-Técnica y Biblioteca de la Facultad de Ciencias Médicas de Bayamo. Para el desarrollo del contenido del sitio se emplearon: observación, encuestas y entrevistas. Para desarrollar el producto se llevaron a cabo cinco procesos: planificación inicial del sitio, definición, diseño y estándares, puesta en marcha y plan de mantenimiento. Para la confección de la página se empleó el gestor de contenidos WordPress, así como PHP, MySQL, Apache, XAMPP y Windows como lenguaje de programación, motor de bases de datos, servidor Web, paquete de software libre y sistema operativo respectivamente. Se concluye que la implementación de la biblioteca virtual, facilita el proceso de gestión de la información, despierta el interés por la investigación y contribuye a la alfabetización informacional de los usuarios de salud que ingresen a la web. Facilitará la visibilidad, la gestión técnica bibliotecaria; la divulgación, difusión, y uso de los servicios y recursos de información disponibles.

Web pages constitute a means of facilitating knowledge. The work was carried out with the objective of designing and implementing a virtual library to favor the information management process of the Department of Scientific and Technical Information and the Library of the Faculty of Medical Sciences of Bayamo. Observation, surveys and interviews were used in the development of the content of the site. Five processes were carried out to develop the product: initial planning of the site, definition, design and standards, commissioning, and maintenance plan. To create the page, the content manager WordPress was used; PHP, MySQL, Apache, XAMPP and Windows were used as the programming language, database engine, Web server, free software package and operating system, respectively. It is concluded that the implementation of the virtual library facilitates the information management process, awakens the interest in research, and contributes to the information literacy of health users who enter the web. It will facilitate visibility, library technical management, disclosure, dissemination, and use of available information services and resources.

Discovery and Optimization of Neutralizing SARS-CoV-2 Antibodies Using ALTHEA Gold Plus Libraries™.

We recently reported the isolation and characterization of anti-SARS-CoV-2 antibodies from a phage display library built with the VH repertoire of a convalescent COVID-19 patient, paired with four naïve synthetic VL libraries. One of the antibodies, called IgG-A7, neutralized the Wuhan, Delta (B.1.617.2) and Omicron (B.1.1.529) strains in authentic neutralization tests (PRNT). It also protected 100% transgenic mice expressing the human angiotensin-converting enzyme 2 (hACE-2) from SARS-CoV-2 infection. In this study, the four synthetic VL libraries were combined with the semi-synthetic VH repertoire of ALTHEA Gold Libraries™ to generate a set of fully naïve, general-purpose, libraries called ALTHEA Gold Plus Libraries™. Three out of 24 specific clones for the RBD isolated from the libraries, with affinity in the low nanomolar range and sub-optimal in vitro neutralization in PRNT, were affinity optimized via a method called "Rapid Affinity Maturation" (RAM). The final molecules reached sub-nanomolar neutralization potency, slightly superior to IgG-A7, while the developability profile over the parental molecules was improved. These results demonstrate that general-purpose libraries are a valuable source of potent neutralizing antibodies. Importantly, since general-purpose libraries are "ready-to-use", it could expedite isolation of antibodies for rapidly evolving viruses such as SARS-CoV-2.

Double Digest Restriction-Site Associated DNA Sequencing (ddRADseq) Technology.

Double digest restriction-site associated DNA sequencing (ddRADseq) technology combines genome reduced representation by digestion with two restriction enzymes and next generation sequencing (NGS) to obtain thousands of markers (SNP, SSR, and InDels) and genotype tens to hundreds of samples simultaneously. In this chapter, we describe a 96-plex derived ddRADseq protocol that can be set up to obtain different depth of coverage per locus and can be exploited to model and non-model plant species.

Functional Metagenomics Approach for the Discovery of Novel Genes Encoding Phosphatase Activity.

Phosphate release from inorganic and organic phosphorus compounds can be enzymatically mediated. Phosphate-releasing enzymes, comprising acid and alkaline phosphatases, are recognized as useful biocatalysts in applications such as plant and animal nutrition, bioremediation, and diagnostic analysis. Here, we describe a functional metagenomics approach enabling rapid identification of genes encoding these enzymes. The target genes are detected based on small- and large-insert metagenomic libraries derived from diverse environments. This approach has the potential to unveil entirely new phosphatase families or subfamilies and members of known enzyme classes that hydrolyze phosphomonoester bonds such as phytases. Additionally, we provide a strategy for efficient heterologous expression of phosphatase genes.

Comportamiento informativo en las bibliotecas de la Facultad de Estudios Superiores Zaragoza de la Universidad Nacional Autónoma de México, antes y durante la pandemia por SARS-CoV-2

Se estudia el comportamiento informativo de alumnos y docentes de la Facultad de Estudios Superiores Zaragoza (FESZ), de la Universidad Nacional Autónoma de México (UNAM), durante la pandemia ocasionada por el SARS-CoV-2, en la Biblioteca Digital UNAM ante el cierre total de las bibliotecas, lo que limitó la consulta presencial de libros y revistas impresas. Se llevó a cabo una investigación cuantitativa con la técnica de análisis de datos estadísticos a partir de las bitácoras de acceso a la Biblioteca Digital (BIDI UNAM) que en suma contempló 15,597 accesos, en comparación a dos periodos, antes y durante la pandemia, obteniendo como resultado un incremento en los accesos, sumado al impulso de estrategias de alfabetización informacional para el uso y aprovechamiento de los recursos de información, mismos que pueden ser integrados en los procesos de enseñanza y aprendizaje, fortaleciendo el modelo educativo de la FESZ.

The informational behavior of students and professors of the Facultad de Estudios Superiores Zaragoza (FESZ) of the Universidad Nacional Autónoma de México (UNAM) during the pandemic caused by SARS-CoV-2, is studied in the Biblioteca Digital UNAM (BIDI UNAM) before the total closure of libraries, which limited the consultation of printed books and journals. A quantitative research was carried out with the statistical data analysis technique from the access logs to the BIDI UNAM, wich in total included 15,597 accesses, compared to two periods, before and during the pandemic, obtaining as a result an increase in accesses, in addition to the promotion of information literacy strategies for the use and exploitation of information resources, which can be integrated into the teaching and learning processes, strengthening the educational model of the FESZ.

Crowdfunding como alternativa para el financiamiento de proyectos en bibliotecas: Una oportunidad frente a los recortes presupuestarios

Esta investigación nace debido a los recortes presupuestarios que sufre el sector cultural en Costa Rica, en particular como una alternativa de financiamiento a los proyectos que ejecutan las bibliotecas. Su objetivo principal es describir las oportunidades que ofrece el crowdfunding como método alternativo de financiamiento en las bibliotecas públicas y académicas para el desarrollo de proyectos sociales. Desde un enfoque cualitativo, se realiza una revisión bibliográfica con alcance descriptivo. Por tanto, se recopilan artículos y tesis sobre crowdfunding en bibliotecas públicas y académicas, asimismo es mediante el cuadro de categorías de análisis que se interpretan los principales puntos de interés para la investigación. Los resultados reflejan la efectividad y adaptabilidad de la implementación de campañas de crowdfunding de donación para la recaudación de fondos en bibliotecas de acuerdo a sus necesidades. Se concluye que en una campaña de este tipo se debe considerar el tiempo estimado para la recaudación de fondos, la adecuada gestión de las redes sociales, una excelente selección del tipo y plataforma de crowdfunding, así como de las habilidades y competencias de las personas a cargo. Los profesionales en bibliotecología deben utilizar el potencial de las TIC en tiempos de austeridad para aprovechar el crowdfunding como una alternativa de financiamiento que permite ejecutar más y mejores proyectos.

This research was born due to budget cuts suffered by the cultural sector in Costa Rica, as a financing alternative to the projects carried out by libraries. Its main objective is to describe the opportunities offered by crowdfunding as an alternative method of financing in public and academic libraries for the development of social projects. From a qualitative approach, a bibliographic review with a descriptive scope is carried out. Therefore, articles and theses on crowdfunding in public and academic libraries are compiled, through the table of analysis categories; the main points of interest for the investigation are interpreted. The results reflect the effectiveness and adaptability of the implementation of donation crowdfunding for fundraising in libraries according to their needs. It is concluded that in a campaign of this type, the estimated time for fundraising, the proper management of social networks, an excellent selection of the type and platform of crowdfunding, as well as the skills and competencies of the people involved should be considered. Library professionals must use the potential of ICT in times of austerity to take advantage of crowdfunding to execute more and better projects.

A combined transcriptome - miRNAome approach revealed that a kinesin gene is differentially targeted by a novel miRNA in an apomictic genotype of Eragrostis curvula.

Weeping lovegrass (Eragrostis curvula [Shrad.] Nees) is a perennial grass typically established in semi-arid regions, with good adaptability to dry conditions and sandy soils. This polymorphic complex includes both sexual and apomictic cytotypes, with different ploidy levels (2x-8x). Diploids are known to be sexual, while most polyploids are facultative apomicts, and full apomicts have also been reported. Plant breeding studies throughout the years have focused on achieving the introgression of apomixis into species of agricultural relevance, but, given the complexity of the trait, a deeper understanding of the molecular basis of regulatory mechanisms of apomixis is still required. Apomixis is thought to be associated with silencing or disruption of the sexual pathway, and studies have shown it is influenced by epigenetic mechanisms. In a previous study, we explored the role of miRNA-mRNA interactions using two contrasting E. curvula phenotypes. Here, the sexual OTA-S, the facultative Don Walter and the obligate apomictic Tanganyika cDNA and sRNA libraries were inquired, searching for miRNA discovery and miRNA expression regulation of genes related to the reproductive mode. This allowed for the characterization of seven miRNAs and the validation of their miRNA-target interactions. Interestingly, a kinesin gene was found to be repressed in the apomictic cultivar Tanganyika, targeted by a novel miRNA that was found to be overexpressed in this genotype, suggestive of an involvement in the reproductive mode expression. Our work provided additional evidence of the contribution of the epigenetic regulation of the apomictic pathway.

Understanding and Modulating Antibody Fine Specificity: Lessons from Combinatorial Biology.

Combinatorial biology methods such as phage and yeast display, suitable for the generation and screening of huge numbers of protein fragments and mutated variants, have been useful when dissecting the molecular details of the interactions between antibodies and their target antigens (mainly those of protein nature). The relevance of these studies goes far beyond the mere description of binding interfaces, as the information obtained has implications for the understanding of the chemistry of antibody-antigen binding reactions and the biological effects of antibodies. Further modification of the interactions through combinatorial methods to manipulate the key properties of antibodies (affinity and fine specificity) can result in the emergence of novel research tools and optimized therapeutics.

Percepciones de estudiantes de enfermería con el uso de la herramienta "Libro" de Moodle / Perceptions of Nursing Students regarding the Use of the "Libro" Moodle Tool

Introducción: La formación de las enfermeras en administración y liderazgo tiene una importante repercusión sobre el presente y el futuro de la profesión. Sin embargo, la docencia y la evaluación realizadas en el nivel de pregrado, en su primer contacto con la materia, pueden generarles insatisfacción. Objetivo: Describir las percepciones de estudiantes de Enfermería sobre una innovación docente basada en el uso del "Libro" de Moodle como herramienta pedagógica, dentro de un enfoque general de clase invertida. Métodos: Estudio mixto exploratorio, realizado entre octubre y diciembre de 2020 en la Universidad de Huelva (España), mediante encuesta anónima sobre una muestra de 140 alumnos (del total de 145 estudiantes del 3º curso). Los datos fueron procesados en Excel y analizados de forma descriptiva (datos cuantitativos) y por categorías (datos cualitativos). Resultados: La valoración media del uso de la herramienta "Libro" fue de 9,10 sobre 10. El 92,00 por ciento de los estudiantes se mostró satisfecho con la metodología de enseñanza y 92,90 por ciento con la evaluación. Los estudiantes manifestaron haber mejorado su opinión sobre los contenidos gracias a la metodología empleada. Conclusión: La mayoría de los estudiantes participantes en este estudio se han mostrado satisfechos con el uso de la herramienta de Moodle dentro de un contexto de docencia a través de clase invertida(AU)

Introduction: The training of nurses in management and leadership has an important impact on the present and future of the profession. However, the teaching and evaluation carried out in the undergraduate level, in their first contact with the subject, can generate dissatisfaction. Objective: To describe the perceptions of students of Nursing Administration and Management regarding a teaching innovation based on using the "Libro" tool in the framework of teaching by means of a flipped classroom. Methods: Exploratory and mixed study carried out between October and December 2020 at the University of Huelva, Spain, by means of an anonymous survey conducted with a sample of 140 students (of the total of 145 students from the third academic year). The data were processed in Excel and analyzed descriptively (quantitative data) and by categories (qualitative data). Results: The average evaluation of using the "Libro" tool was 9.10 out of 10. 92.00 percent of the students were satisfied with the teaching methodology and 92.90 percent were satisfied with the evaluation. The students stated that their opinion of the contents had improved thanks to the methodology used. Conclusion: Most of the students participating in this study were satisfied with the use of the Moodle tool within a teaching setting of flipped classroom(AU)

[The librarian at the Instituto Mexicano del Seguro Social]. / El bibliotecario en el Instituto Mexicano del Seguro Social.

In the information units that make up the Instituto Mexicano del Seguro Social (IMSS) Library System, the task of guiding and training users on the use of information is a complex process, due to the specificity of the users' information needs. The information systems that are used in the Institute require the personal librarian to have specific information skills for access, evaluation, organization and use of information through information technologies. However, there are important challenges, such as the lack of definition of the professional profile of the medical librarian, because it is essential for the staff to efficiently satisfy the demands and needs of users according to their various profiles.

En las unidades de información que integran el Sistema Bibliotecario del Instituto Mexicano del Seguro Social (IMSS), la tarea de orientar y formar a los usuarios sobre el uso de información es un proceso complejo, debido a la especificidad de las necesidades de información de los usuarios. Los sistemas de información que son utilizados en el Instituto exigen al personal bibliotecario contar con competencias informativas específicas para el acceso, evaluación, organización y uso de la información por medio de las tecnologías de la información. Sin embargo, existen grandes retos, como la carencia de la definición del perfil profesional del bibliotecario médico, ya que es indispensable para que el personal logre satisfacer de forma eficiente las demandas y necesidades de los usuarios de acuerdo con sus diversos perfiles.

El bibliotecario en el Instituto Mexicano del Seguro Social / The librarian at the Instituto Mexicano del Seguro Social

En las unidades de información que integran el Sistema Bibliotecario del Instituto Mexicano del Seguro Social (IMSS), la tarea de orientar y formar a los usuarios sobre el uso de información es un proceso complejo, debido a la especificidad de las necesidades de información de los usuarios. Los sistemas de información que son utilizados en el Instituto exigen al personal bibliotecario contar con competencias informativas específicas para el acceso, evaluación, organización y uso de la información por medio de las tecnologías de la información. Sin embargo, existen grandes retos, como la carencia de la definición del perfil profesional del bibliotecario médico, ya que es indispensable para que el personal logre satisfacer de forma eficiente las demandas y necesidades de los usuarios de acuerdo con sus diversos perfiles.

In the information units that make up the Instituto Mexicano del Seguro Social (IMSS) Library System, the task of guiding and training users on the use of information is a complex process, due to the specificity of the users' information needs. The information systems that are used in the Institute require the personal librarian to have specific information skills for access, evaluation, organization and use of information through information technologies. However, there are important challenges, such as the lack of definition of the professional profile of the medical librarian, because it is essential for the staff to efficiently satisfy the demands and needs of users according to their various profiles.

Spectral data of tropical soils using dry-chemistry techniques (VNIR, XRF, and LIBS): A dataset for soil fertility prediction.

Proximal soil sensing technologies, such as visible and near infrared diffuse reflectance spectroscopy (VNIR), X-ray fluorescence spectroscopy (XRF), and laser-induced breakdown spectroscopy (LIBS), are dry-chemistry techniques that enable rapid and environmentally friendly soil fertility analyses. The application of XRF and LIBS sensors in an individual or combined manner for soil fertility prediction is quite recent, especially in tropical soils. The shared dataset presents spectral data of VNIR, XRF, and LIBS sensors, even as the characterization of key soil fertility attributes (clay, organic matter, cation exchange capacity, pH, base saturation, and exchangeable P, K, Ca, and Mg) of 102 soil samples. The samples were obtained from two Brazilian agricultural areas and have a wide variation of chemical and textural attributes. This is a pioneer dataset of tropical soils, with potential to be reused for comparative studies with other datasets, e.g., comparing the performance of sensors, instrumental conditions, and/or predictive models on different soil types, soil origin, concentration range, and agricultural practices. Moreover, it can also be applied to compose soil spectral libraries that use spectral data collected under similar instrumental conditions.

[Information services facing the COVID-19 pandemic]. / Los servicios de información ante la pandemia por COVID-19.

The COVID-19 pandemic caused various effects in the world, among them the saturation of information in the traditional media, as well as in those of scientific dissemination, due to the accelerated production of informative material. At the Mexican Institute for Social Security (Instituto Mexicano del Seguro Social), librarians have contributed to the careful selection of documents as they are in charge of providing specialized information services to health personnel in order to support them in academic, educational, teaching and research activities. In the context of physical distancing, the need for up-to-date and accurate information on the new coronavirus became a priority. In this sense, librarians have focused their efforts to carry out strategies that would allow to provide specialized information services remotely, reinforcing reference services such as bibliographic alert and Selective Information Dissemination, to reach users in a timely manner, simple and agile, updated, reliable and quality information on COVID-19. These services have been well received by users, but it is still necessary to systematize the provision of information services to identify which documents are of greatest interest and usefulness.

La pandemia por COVID-19 ocasionó diversas afectaciones en el mundo, entre ellas la saturación de información en los medios de comunicación tradicionales y en los de divulgación científica, debido a la producción acelerada de material informativo. En el Instituto Mexicano del Seguro Social, el personal bibliotecario ha contribuido a la selección cuidadosa de documentos, ya que brinda servicios de información especializada al personal de salud para apoyarlo en actividades académicas, educativas, docentes y de investigación. En el contexto del distanciamiento físico, la necesidad de contar con información actualizada y veraz sobre el nuevo coronavirus se convirtió en una prioridad. En este sentido, el personal bibliotecario enfocó sus esfuerzos en llevar a cabo estrategias que permitieran brindar servicios de información especializada vía remota al reforzar los servicios de referencia, como la alerta bibliográfica y la Diseminación Selectiva de Información, a fin de hacer llegar a los usuarios, de forma oportuna, sencilla y ágil, información actualizada, confiable y de calidad sobre la COVID-19. Estos servicios han sido bien recibidos por los usuarios, pero aún es necesario sistematizar el otorgamiento de servicios de información para identificar cuáles documentos son de mayor interés y utilidad.

Bibliotecas universitarias y derecho de autor: un par dialéctico en tiempos de pandemia / University libraries and copyright: a dialectical pair in times of pandemic

RESUMEN Las bibliotecas universitarias juegan un rol fundamental en el proceso enseñanza aprendizaje. Bajo el influjo de los procesos de digitalización estas instituciones diversifican su actuar para convertirse en centro de recursos para el aprendizaje y la investigación, y fomentan la creación de repositorios institucionales de acceso abierto. La actividad bibliotecaria en entornos digitales demanda una adecuación de las normas autorales que les permita desarrollar sus funciones sin lesionar las facultades de los autores y titulares del derecho de autor. Las autoras exponen algunos apuntes críticos sobre la relación biblioteca-derechos de autor en tiempos pandémicos.

ABSTRACT University libraries play a fundamental role in the teaching-learning process. Under the influence of digitization processes, these institutions diversify their actions to become a resource center for learning and research, and promote the creation of institutional open access repositories. The library activity in digital environments demands an adaptation of the authorial norms that allows them to develop their functions without harming the faculties of the authors and copyright holders. The authors present some critical notes on the library-copyright relationship in pandemic times.