RESUMEN
While the Fluid Mosaic model (FMM) is widely accepted as an account of the cell membrane's structure-function, its inability to explain certain phenomena has led to the lipid rafts hypothesis (nanodomains) that spontaneous spatiotemporal enriched zones of sphingolipids-cholesterol-protein exist within the membrane. In this text, we propose a novel approach that conceives the cell membrane as a living entity. The questions regarding the FMM revolve around the fact that, although these molecular components are present in many cell types, the membrane does not react in the same way to every external agent; for example, a virus evokes a particular response: why is there some marked specificity of virus (or toxin) attack on one (or some) of these cell types and not to other cell types that nevertheless have a similar membrane protein constitution? The crucial question, to explain this selectivity, would be what determines the specificity of attack on some cells and not others? While FMN assumes a dynamism between macrostates at the intramolecular, intermolecular, and/or collective levels in the membrane, the approach of the lipid raft model presupposes a much greater and more complex dynamics of microstates (even nano-states) of these molecular components. In other words, it implies higher and instantaneous mobility as assemblages ("intentional") and thus, of the membrane itself (as a collective), in response to changes in the internal and external physicochemical environment over a broad spatiotemporal scale. This suggests a mechanism of membrane adaptation in the face of evolutionary constraints. In this text, we propose a paradigmatic approach, from Deleuze-Guattari's philosophy: to conceive the cell membrane as living and not as a mere molecular conglomerate with particular functions and mechanical processes between molecules. For this, we employ the functional concepts of territory and machinic assemblage, whence the vitality of the membrane would allow us to postulate instantaneous updates, within wider spatiotemporal scales in its composition in contrast with the model that dominates as a more plausible explanation nowadays, that does not include smaller spatiotemporal events. If we resort to the concept of territory and its different media components, we could offer a more plausible explanation of the vigorous dynamism in the composition of the cell membrane since it would allow more subtle and complex differentiations between media and thus make visible the constant and instant changes. We propose that the model of nanodomains, understood as a process of dynamic territorialization, offers a more complex and subtle explanation of the instantaneous changes in the cell membrane's composition. This approach expands the explanatory framework for cellular phenomena and reveals their spatiotemporal complexity in accordance with other research.
RESUMEN
El objetivo de este escrito es articular epistemológicamente las enseñanzas clínicas de Donald Winnicott y el pensamiento filosófico de Félix Guattari y Gilles Deleuze. Aborda específicamente los puntos de intercepción entre el concepto de lo transicional y el de agenciamiento maquínico, con base en la hipótesis de trabajo sobre una referencia común al problema de la producción transitiva de signos, que se despliega en medio de un mismo plano de inmanencia, en el que operan compositivamente una multiplicidad de elementos para la formación consistente de sistemas acentrados y mutables. Para este ejercicio se recurre especialmente al artículo del psicoanalista inglés: "Objetos transicionales y fenómenos transicionales" (1951/2008b), publicado en la edición póstuma de La Realidad y el Jugar (1971/2008a), así como al escrito de los filósofos franceses: "Rizoma", editado en Mil Mesetas (1980/2006).(AU)
O objetivo deste trabalho é articular epistemologicamente os ensinos clínicos de Donald Winnicott e pensamento filosófico de Gilles Deleuze e Felix Guattari . Aborda especificamente os pontos de intersecção entre o conceito do transicional e o agenciamento maquínico, com base na hipótese de trabalho de uma referência comum para o problema da produção transitiva de sinais, que se desdobra em meio a um mesmo plano de imanência, no qual operam compositivamente uma multiplicidade de elementos para a formação consistente de sistemas acentrados e mutáveis . Para este exercício, se recorre especialmente ao artigo do psicanalista inglês: "objetos transicionais e fenômenos transicionais" ( 1951/2008b ) , publicado na edição póstuma de Realidade e Jogo ( 1971/2008a ), bem como ao escrito dos filósofos franceses " Rizoma " , publicado em Mil Platôs (1980 /2006).(AU)
The purpose of this paper is to epistemologically articulate the clinics teachings of Donald Winnicott and philosophical thought of Felix Guattari and Gilles Deleuze. It specifically addresses the points of interception between the concept of the transitional and the machinic assemblage, based on the working hypothesis of a common reference to the transitive production of signs, that unfolds in the midst of one plane of immanence in which operate compositionally a multiplicity of elements for consistent training ofuncentered and mutable systems. For this exercise are used especially the article of english psychoanalyst «Transitional objects and transitional phenomenas» (1951/2008b), published in the posthumous edition of Playing and Reality (1971/2008a), and the text of french philosophers: «Rhizome», published in A Thousand Plateaus (1980/2006).(AU)
Asunto(s)
Conocimiento , PsicoanálisisRESUMEN
El objetivo de este escrito es articular epistemológicamente las enseñanzas clínicas de Donald Winnicott y el pensamiento filosófico de Félix Guattari y Gilles Deleuze. Aborda específicamente los puntos de intercepción entre el concepto de lo transicional y el de agenciamiento maquínico, con base en la hipótesis de trabajo sobre una referencia común al problema de la producción transitiva de signos, que se despliega en medio de un mismo plano de inmanencia, en el que operan compositivamente una multiplicidad de elementos para la formación consistente de sistemas acentrados y mutables. Para este ejercicio se recurre especialmente al artículo del psicoanalista inglés: "Objetos transicionales y fenómenos transicionales" (1951/2008b), publicado en la edición póstuma de La Realidad y el Jugar (1971/2008a), así como al escrito de los filósofos franceses: "Rizoma", editado en Mil Mesetas (1980/2006).
O objetivo deste trabalho é articular epistemologicamente os ensinos clínicos de Donald Winnicott e pensamento filosófico de Gilles Deleuze e Felix Guattari . Aborda especificamente os pontos de intersecção entre o conceito do transicional e o agenciamento maquínico, com base na hipótese de trabalho de uma referência comum para o problema da produção transitiva de sinais, que se desdobra em meio a um mesmo plano de imanência, no qual operam compositivamente uma multiplicidade de elementos para a formação consistente de sistemas acentrados e mutáveis . Para este exercício, se recorre especialmente ao artigo do psicanalista inglês: "objetos transicionais e fenômenos transicionais" ( 1951/2008b ) , publicado na edição póstuma de Realidade e Jogo ( 1971/2008a ), bem como ao escrito dos filósofos franceses " Rizoma " , publicado em Mil Platôs (1980 /2006).
The purpose of this paper is to epistemologically articulate the clinics teachings of Donald Winnicott and philosophical thought of Felix Guattari and Gilles Deleuze. It specifically addresses the points of interception between the concept of the transitional and the machinic assemblage, based on the working hypothesis of a common reference to the transitive production of signs, that unfolds in the midst of one plane of immanence in which operate compositionally a multiplicity of elements for consistent training ofuncentered and mutable systems. For this exercise are used especially the article of english psychoanalyst ®Transitional objects and transitional phenomenas¼ (1951/2008b), published in the posthumous edition of Playing and Reality (1971/2008a), and the text of french philosophers: ®Rhizome¼, published in A Thousand Plateaus (1980/2006).