Evaluation of the success of predicted dental changes with clear-aligner treatment: A pilot study.

Objective: This pilot study concerned evaluation of the success of predicted dental changes in patients presenting with Class I malocclusions who were submitted to treatment aligners, using the superimposition. Methods: The digital models were superimposed and analyzed using 3DSlicer 5.0 software. Treatment and predicted changes regarding horizontal and vertical linear displacements, mesiodistal rotations, and incisor buccolingual tipping were quantified. The success rates were calculated by dividing the mean treatment change amount by the predicted change amount. Results: Lower-incisor intrusion was the most accurate of the predicted vertical displacements (86.96 %), and buccal expansion of upper canines (99.32 %) and mesial translation of the lower incisors (98.57 %) were the most accurate horizontal linear displacements. The predicted rotation was achieved with the highest accuracy for lower incisors (75.69 %). Incisor buccolingual tipping success rates ranged between 45.78 % and 69.31 %. Low accuracy of predicted changes was found for upper-molar extrusion (10.23 %) and constriction (8.91 %). However, minimal corrections in these directions were planned. Conclusions: Dental changes for all regions of maxillary and mandibular arches could be evaluated. High success rates were observed for most of the movements planned for ClearCorrect aligner therapy.

The effect of micro-osteoperforations on the rate of maxillary incisors' retraction in orthodontic space closure: a randomized controlled clinical trial.

BACKGROUND: This single-centered randomized controlled clinical trial aimed to evaluate the effectiveness of micro-osteoperforations (MOPs) in accelerating the orthodontic retraction of maxillary incisors. METHODS: Forty-two patients aged 16-40 were recruited and randomly assigned into two groups, one which underwent MOPs (MOPG) in the buccal and palatal region of all maxillary incisors immediately before the start of retraction and one which did not (CG). Eligibility criteria included the orthodontic need for maxillary first premolars extraction and space closure in two phases. The primary outcome of the study consisted of measuring the rate of space closure and, consequently, the rate of incisors' retraction using digital model superimposition 14 days later and monthly thereafter for the next 4 months. The secondary outcomes included measuring anchorage loss, central incisors' inclination, and root length shortening, analyzed using cone beam computed tomography scans acquired before retraction and 4 months after retraction. Randomization was performed using QuickCalcs software. While clinical blinding was not possible, the image's examinator was blinded. RESULTS: Twenty-one patients were randomly assigned to each group. However, due to various reasons, a total of 37 patients (17 male and 20 female) were analyzed (mean age: 24.3 ± 8.1 years in the MOPG; 22.2 ± 4.2 years in the CG) during the trial. No statistically significant difference was found between the MOPG and the CG regarding the incisors' retraction measured at different time points at the incisal border (14 days, 0.4 mm vs. 0.5 mm; 1 month, 0.79 mm vs. 0.77 mm; 2 months, 1.47 mm vs. 1.41 mm; 3 months, 2.09 mm vs. 1.88 mm; 4 months, 2.62 mm vs. 2.29 mm) and at the cervical level (14 days, 0.28 mm vs. 0.30 mm; 1 month, 0.41 mm vs. 0.32 mm; 2 months, 0.89 mm vs. 0.61 mm; 3 months, 1.36 mm vs. 1.10 mm; 4 months, 1.73 mm vs. 1.39 mm). Similarly, no statistically significant differences were detected in the space closure, anchorage loss, central incisors' inclination, and radicular length between groups. No adverse effect was observed during the trial. CONCLUSIONS: MOPs did not accelerate the retraction of the maxillary incisors, nor were they associated with greater incisor inclination or root resorption. Trial registration ClinicalTrials.gov NCT03089996. Registered 24 March 2017- https://clinicaltrials.gov/ct2/show/NCT03089996 .

Comparison of the efficiency of initial dental alignment with Invisalign® aligners changed every 7 or 14 days in mature adults: Randomized clinical trial.

OBJECTIVE: To compare the anterior crowding correction after sequential use of the first 5 aligners between two aligner exchange protocols (7 and 14 days) in mature adult patients. MATERIALS AND METHODS: Thirty-six patients over 35 years who received orthodontic treatment with Invisalign® were randomly allocated to two different aligner replacement sequence protocols: Group 1: exchange every 7 days (n = 18); and Group 2: exchange every 14 days (n = 18). All patients were scanned with iTero Element 5D® (Align Technology) in two treatment times: at pre-treatment (T1) and after using the first five aligners (T2). Little's Irregularity Index (LII) and arch widths were evaluated with OrthoCAD software. Intra and intergroup comparisons were performed with the dependent and independent t-tests. The results were considered significant for P < .05. RESULTS: Thirty-five patients completed the study. Both groups' maxillary and mandibular Irregularity Indexesi were significantly lower at T2. There was no significant difference in inter-canine, inter-premolar, and intermolar distances. G2 (14 days) presented a greater decrease in mandibular irregularity than G1 (7 days). CONCLUSION: Both exchange protocols (7 and 14 days) effectively correct anterior crowding in the initial phase of orthodontic treatment with aligners in mature adult patients. However, the 14-day exchange protocol provided a greater correction in mandibular anterior crowding in the evaluated period than the 7-day exchange protocol.

Eficiência da prescrição de bráquetes ortodônticos no tratamento com diferentes sistemas de bráquetes - uma proposta clínica / Orthodontic bracket prescription efficiency in treatment with different bracket systems - a clinical proposal

Com a diversificação das prescrições existentes, a correta escolha de acordo com a necessidade individual de cada má oclusão pode ser importante para estabelecer maior controle biomecânico durante o tratamento ortodôntico. Este estudo teve como objetivo avaliar o tratamento ortodôntico com a versatilidade na associação de diferentes prescrições em um relato de caso clínico e determinar se existe alguma relação com a dimensão vertical, transversal e o perímetro de arco que podem contribuir com a estabilidade e longevidade do tratamento ortodôntico. A prescrição, quando corretamente indicada, tem impacto no controle do movimento dentário para estabelecer oclusão, estética e estabilidade adequadas. Concluiu-se que o surgimento de novas prescrições tende a favorecer ao máximo a abrangência de mais pacientes no tratamento ortodôntico (AU)

With the diversification of existing bracket prescriptions, the correct choice according to the individual needs of each malocclusion is essential to establish greater biomechanical control during orthodontic treatment. This study aimed to evaluate orthodontic treatment with the versatility in association of different prescriptions in a clinical case report and to determine whether there is any relationship with the vertical dimension, transverse dimension, and arch perimeter that can contribute to the stability and longevity of the orthodontic treatment. The prescription, when correctly indicated, has an impact on the control of tooth movement to establish proper occlusion, esthetics, and stability. It was concluded that the emergence of new prescriptions favors the maximum coverage of more patients in orthodontic treatment. (AU)

Utilização do Carriere® Motion 3DTM na correção da má oclusão de Classe II / Use of the Carriere® Motion 3DTM to correct Class II malocclusion

Uma opção de tratamento para a má oclusão de Classe II de Angle é a distalização dos molares superiores, que pode ser obtida através de diferentes estratégias. O Carriere® Motion 3DTM (CM3D) é uma alternativa recente para a correção desse tipo de má oclusão e vem alcançando resultados bastante satisfatórios, por meio da distalização em bloco do segmento posterior superior, com controle tridimensional do movimento dentário. Esse aparelho apresenta um design moderno e pode ser utilizado tanto nos casos de Classe II unilaterais como bilaterais. Este trabalho tem como objetivo apresentar o caso de um paciente de 14 anos, portador de uma má oclusão de Classe II divisão 2, que foi tratado com CM3D e ancoragem inferior com arco lingual de Nance. Inicialmente foi instalado o CM3D por quatro meses para correção sagital, seguido por aparelho fixo total superior e inferior para finalização do caso. Após 24 meses de tratamento, observou-se significante melhora no sorriso e no perfil do paciente. CM3D é uma opção eficaz, prática, estética e de fácil aplicação profissional e bem aceito pelo paciente para o tratamento da má oclusão de Classe II. (AU)

A treatment option for Class II Angle occlusion is the distalization of the upper molars, which can inform through different strategies. The Carriere® Motion 3DTM (CM3D) is a recent alternative for the correction of this type of malocclusion and it has been achieving satisfactory results, utilizing block distalization of the upper posterior segment, with three-dimensional control of tooth movement. This device has a modern design and can be used in both unilateral and bilateral Class II cases. This study aims to present a case of a 14-year-old patient with Class II division 2 malocclusion, who was treated with the CM3D and lower anchorage with Nances lingual arch. Initially, it was installed a CM3D for four months for sagittal correction, followed by a total upper and lower fixed device for finalizing the case. After 24 months of detected treatment, the the patients' smile and profile significantly improved. The CM3D is a useful, practical, aesthetic, and easy to apply professional and well accepted option for the treatment of Class II malocclusion.(AU)

Orthodontic treatment in traumatized permanent teeth: a systematic review / Tratamento ortodôntico em dentes permanentes traumatizados: uma revisão sistemática

Objective: to analyze, through literature review, the available literature on orthodontic treatment in traumatized permanent teeth. Methods: A literature search was performed in electronic databases (PubMed and SciELO) using the descriptors [tooth injuries] OR [injuries, teeth] OR [injury, teeth] OR [teeth injury] OR [injuries, tooth] OR [injury, tooth] OR [tooth injury] OR [teeth injuries] AND [orthodontics]. Observational studies and clinical trials were included, narrative reviews, laboratory and in vitro studies, case reports and series as well as articles that presented abstracts written in languages other than Portuguese, English and Spanish were excluded from the study. Two reviewers considered the eligibility, the risk of bias of the analyzed data and the qualitative synthesis of the studies included. A total of 1,322 references were found and 4 articles met all inclusion criteria and were included in the qualitative analysis. Some consequences like pulp necrosis and root resorption have been highlighted and trauma severity should be considered when orthodontically intervening in previously traumatized teeth. Final considerations: The traumatized teeth can be orthodontically treated as long as the time of tissue reorganization is respected, and the pull and periodontal conditions are followed up.(AU)

Objetivos: analisar, por meio de revisão de literatura, a respeito do tratamento ortodôntico em dentes permanentes traumatizados. Metodologia: Uma pesquisa bibliográfica foi realizada em bancos de dados eletrônicos (PubMed e SciELO) usando os descritores [tooth injuries] ou [injuries, teeth] ou [injury, teeth] ou [teeth injury] ou [injuries, tooth] ou [injury, tooth] ou [tooth injury] ou [teeth injuries] e [orthodontics]. Foram incluídos estudos observacionais e ensaios clínicos, revisões narrativas, estudos laboratoriais e in vitro, relatos de casos e séries, bem como artigos que apresentassem resumos redigidos em idiomas diferentes do português, inglês e espanhol foram excluídos do estudo. Dois revisores consideraram a elegibilidade, o risco de viés dos dados analisados e a síntese qualitativa dos estudos incluídos. Foram encontradas 1.322 referências e 4 artigos atenderam a todos os critérios de inclusão e foram incluídos na análise qualitativa. Algumas consequências como necrose pulpar e reabsorção radicular têm sido destacadas e a gravidade do trauma deve ser considerada na intervenção ortodôntica em dentes previamente traumatizados. Considerações finais: Os estudos incluídos nesta revisão sugerem que dentes traumatizados podem ser tratados ortodônticamente desde que respeitado o tempo de reorganização tecidual e acompanhadas as condições pulpares e periodontais.(AU)

Calcitonin as a pharmacological anchorage in orthodontics.

Objective: This study aimed to evaluate the effects of salmon calcitonin administration as a pharmacological anchoring agent in orthodontics and to determine the influence of locally applied calcitonin on serum calcium levels. The secondary aim was to observe the response of dental and periodontal tissues using light microscopy. Methods: Fourteen healthy male adult Wistar rats with an average weight of 250 g had their teeth moved, seven of which received a local injection of salmon calcitonin in the furcation region of the left upper first molar. Concurrently, the remaining seven were used as controls. In the control group, saline solution was injected in the bifurcation region of tooth 26 to subject these animals to the same stress level as those of the experimental group. After 14 days, a 6 mm diameter orthodontic elastic band was inserted between teeth 26 and 27 in all animals to induce the movement of these teeth. The rats were anaesthetised and exsanguinated on day 21. In both groups, tooth movement and serum calcium levels were measured. The jaws were dissected with straight scissors, and tissue blocks containing gingiva, bone and teeth were identified, fixed and demineralised. Then, the pieces were cut into semi-serial slices, stained with hematoxylin, eosin, and Mallory's trichrome, and analysed under an Axiophot light microscope. Results: There was significantly less tooth movement in the experimental group (X̄; 0,150 mm ± 0,037) than in the control group (0,236 mm ± 0,044; P = 0,003), while there was no significant difference in serum calcium levels between the two groups (controlX̄; 9,53 mg/dl ± 1,53; experimental 10,81 mg/dl ± 1,47; P = 0,15). Conclusion: While calcitonin did not completely inhibit osteoclast activity, it promoted orthodontic anchorage, apparently, by local action.

Analgesia por láser de baja potencia en pacientes con tratamiento ortodóncico / Low power laser analgesia in patients with orthodontic treatment i: en

Introducción: El dolor es el síntoma más común luego de la primera activación de la aparatología ortodóncica. El tratamiento analgésico más utilizado es el paracetamol; sin embargo, su uso inhibe la actividad de la ciclooxigenasa y la síntesis de prostaglandinas, lo que puede afectar el mecanismo del movimiento dental y el remodelado óseo. Objetivo: Evaluar la efectividad del láser de baja potencia para el alivio del dolor en pacientes con tratamiento ortodóntico. Métodos: Se realizó un estudio cuasiexperimental de intervención terapéutica, desde enero hasta diciembre de 2020, en 40 pacientes atendidos en la consulta de ortodoncia del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, en quienes se aplicaría fuerza ortodóncica por primera vez. Estos fueron distribuidos de forma aleatoria en 2 grupos de 20 integrantes cada uno: el de estudio, tratado con láser de baja potencia, y el de control, que recibió medicación convencional (paracetamol). Para la validación estadística de la información se emplearon el porcentaje y la prueba de la t de Student para muestras independientes, con 95 % de confiabilidad. Resultados: Luego de tres sesiones terapéuticas, 90,0 % del grupo de estudio refirió no presentar dolor o sentirlo de forma leve, mientras que del grupo de control solo 10,0 % de los pacientes fue ubicado en cualquiera de las dos categorías anteriores. Existió diferencia significativa entre ambos grupos (p=0,00). Conclusiones: Se demostró que el láser, como terapia alternativa, fue más efectivo que el paracetamol.

Introduction: Pain is the most common symptom after the first activation of orthodontic appliance. The most widely used analgesic treatment is paracetamol; however, its use inhibits cyclooxygenase activity and prostaglandin synthesis, which can affect the mechanism of tooth movement and bone remodeling. Objective: To evaluate the effectiveness of low power laser for pain relief in patients with orthodontic treatment. Methods: A quasi-experimental study of therapeutic intervention was carried out, from January to December 2020, in 40 patients treated at the orthodontic clinic of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, in whom orthodontic force was applied for the first time. These were randomly distributed into 2 groups of 20 members each: the study group, treated with low-power laser, and the control group, that received conventional medication (paracetamol). For statistical validation of data, the percentage and the Student's t test for independent samples were used, with 95 % confidence interval. Results: After three therapeutic sessions, 90.0% of the study group reported not presenting pain or feeling it slightly, while only 10.0% of patients in control group were put in any of the two previous categories. There was a significant difference between both groups (p=0.00). Conclusions: Laser, as an alternative therapy, was shown to be more effective than paracetamol.

É possível realizar tracionamento ortodôntico cirúrgico em incisivo com dilaceração radicular? / Is it possible to perform surgical orthodontic traction on incisor with root dilaceration?

Resumo Introdução: O traumatismo dental na dentição decídua pode influenciar o desenvolvimento dos sucessores permanentes e causar um deslocamento da coroa em relação à raiz dental, gerando uma curvatura definida como dilaceração, que em grande parte dos casos impede a irrupção normal do dente permanente. Diversas são as possibilidades de tratamento, desde exodontia ao tratamento ortocirúrgico. Objetivo: O presente trabalho tem o objetivo de relatar um caso clínico de incisivo central superior esquerdo (21) com dilaceração radicular cujo tratamento envolveu procedimento cirúrgico e tracionamento ortodôntico ancorado no disjuntor maxilar. Resultado: O desfecho do tratamento foi satisfatório, visto que o dente incluso foi reposicionado e a má oclusão da paciente foi corrigida. Conclusão: O tracionamento ortocirúrgico de incisivo superior permanente com dilaceração radicular é desafiador e com prognóstico incerto. Contudo, seu reposicionamento é possível quando se realiza um diagnóstico, planejamento periodontal e biomecânico adequado (AU)

Abstract Introduction: Dental trauma in the primary dentition can influence the development of permanent successors and cause a displacement of the crown in relation to the dental root, generating a curvature defined as laceration, which in most cases prevents the normal eruption of the permanent tooth. There are several treatment possibilities, from extraction to orthosurgical treatment. Objective: The present study aims to report a clinical case of a left upper central incisor (21) with root laceration whose treatment involved a surgical procedure and orthodontic traction anchored in the maxillary breaker. Result: The treatment outcome was satisfactory, since the included tooth was repositioned and the patients' malocclusion was corrected. Conclusion: Orthosurgical traction of the permanent upper incisor with root dilaceration is challenging and has an uncertain prognosis. However, its repositioning is possible when a diagnosis, periodontal and biomechanical planning is performed.(AU)

The Effects of Orthodontic Tooth Movement on Clinical Attachment Level Changes in Treated Periodontitis Adult Patients with Malocclusion: A Systematic Review and Meta-analysis

ABSTRACT Objective: To investigate the effects of orthodontic tooth movement on clinical attachment level (CAL) changes in treated periodontitis in adult patients with malocclusion. Material and Methods: Present study is based on PRISMA guidelines; all articles published in international databases such as PubMed, Scopus, Science Direct, and Embase between 2012 to May 2022 are included. 95% confidence interval (CI) for mean difference with fixed effect modal and inverse-variance were calculated. Data analysis was performed using STATA.V16 software. Results: In the initial review, duplicate studies were eliminated, abstracts of 175 studies were reviewed, two authors reviewed the full text of 21 studies, and finally, eleven studies were selected. The mean of CAL gain was 2.29 mm (MD, 95% CI -2.47 mm, -2.12 mm; p=0.00) (I2=91.81%; p=0.00; high heterogeneity). The mean difference of PPD changes was -1.93 mm (MD, 95% CI -2.07 mm, -1.80 mm; p=0.00) (I2=98.52%; p=0.00; high heterogeneity). Conclusion: Due to the limitations of the study and based on the meta-analysis, it is observed that orthodontic treatment is performed with higher success after reconstructive surgery with periodontal improvement.

Influence of risedronate on orthodontic tooth movement in rodents: a systematic review and case report

ABSTRACT Introduction: Bisphosphonates have an inhibitory impact on osteoclastic activity, reducing bone resorption. However, the influence of risedronate on tooth movement is not well-defined. Objective: This systematic review assessed the effect of risedronate intake on orthodontic tooth movement. A case report was also provided. Methods: Two independent reviewers searched six databases (PubMed, Web of Science, Ovid, Lilacs, Scopus, and Open Grey). The searches were carried out in April/2020, and an update was set in place in June/2023. Therefore, the searches considered a timeline from the databases' inception date until June/2023, with no publication date and/or language restrictions. The clinical question focused on evaluating the orthodontic tooth movement and relapse movement (Outcome) in animals (Population) exposed to risedronate (Exposure), compared to control groups (Comparison). The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were applied, and the protocol was registered in PROSPERO (CRD42020168581). The risk of bias was determined using the Systematic Review Centre for Laboratory Animal Experimentation protocol (SYRCLE). Results: Two studies in rats and one in guinea pigs were included in the systematic review. The studies reported a decrease in orthodontic tooth movement, a reduction in the relapse movement, and a reduced number of positive tartrate-resistant acid phosphatase (TRAP) cells, with a significantly reduced number of bone gaps after the administration of risedronate in rats. A case report illustrated the effects of risedronate administration in one patient. Conclusion: Based on the systematic review, risedronate seems to impair orthodontic tooth movement and relapse due to a decrease in bone resorption cells.

RESUMO Introdução: Os bifosfonatos têm um impacto inibitório na atividade osteoclástica, reduzindo a reabsorção óssea. No entanto, a influência do risedronato no movimento dentário não está bem definida. Objetivo: Esta revisão sistemática avaliou o efeito do uso de risedronato no movimento ortodôntico dos dentes. Um relato de caso também é apresentado. Métodos: Dois revisores independentes pesquisaram seis bases de dados (PubMed, Web of Science, Ovid, Lilacs, Scopus e Open Grey), considerando o período de abril de 2020 até junho de 2023, sem restrições de data e/ou idioma de publicação. A questão clínica focou em avaliar o movimento ortodôntico dos dentes e movimento de recidiva (resultado) em animais (população) expostos ao risedronato (exposição) em comparação com grupos de controle (comparação). Foram aplicadas as Diretrizes Preferenciais para Revisão Sistemática e Metanálise (PRISMA) e um protocolo foi registrado no PROSPERO (CRD42020168581). O risco de viés foi determinado utilizando o protocolo do Centro de Revisão Sistemática para Experimentação em Animais de Laboratório (SYRCLE). Resultados: Dois estudos em ratos e um em porquinhos-da-índia foram incluídos na revisão sistemática. Os estudos relataram uma diminuição no movimento ortodôntico dos dentes, uma redução no movimento de recidiva e um número reduzido de células positivas à fosfatase ácida tartarato-resistente (TRAP) com um número significativamente reduzido de falhas ósseas após a administração de risedronato em ratos. Um relato de caso ilustrou os efeitos da administração de risedronato em uma paciente. Conclusão: Com base na revisão sistemática, o risedronato parece interferir no movimento ortodôntico dos dentes e na recidiva devido a uma diminuição nas células de reabsorção óssea.

Deflection of tandem archwire in a specific self-ligating metal bracket system: an in vitro study

Abstract The aim of this study was to quantify the force exerted by tandem archwires in a specific system of passive self-ligating bracket. Forty-eight thermo-activated nickel-titanium orthodontic archwires were separated into four groups (n = 12): G1 - two .014" + .014" round archwires; G2 - two .014" + .016" round archwires; G3 - .014" x .025" rectangular archwire; and. G4 - .016" x .022" rectangular archwire. Brackets were fixed onto teeth 1.5 to 2.5 using a device that represented the upper teeth, maintaining an interbracket distance of 6.0 mm. The deflection tests were performed using the structure representative of tooth 1.1 as support on the Instron testing machine at a speed of 2.0 mm/min. The archwires were evaluated at deflections of 0.5 mm, 1.0 mm, and 1.5 mm. The data were analyzed by a generalized linear model, considering values at different deflections as repeated measurements in the same experimental unit (α = 0.5%). At 0.5 mm, higher forces were observed in G2 and G3, which did not differ significantly (p > 0.05). The lowest force was observed in G4 (p < 0.05). At 1.0 mm and 1.5 mm, the highest force was observed in G3, followed by G4 and G2 (p < 0.05). The lowest force was observed in G1 (p < 0.05). In general, tandem archwires (same or different calibers) in a specific passive self-ligating bracket exerted lower force when compared with rectangular archwires.

Prevalence of non-carious cervical lesions and orthodontic treatment: a retrospective study.

BACKGROUND: This study aimed to assess the distribution of non-carious cervical lesions (NCCLs) by tooth type, investigate the prevalence of NCCLs in patients undergoing orthodontic treatment, and identify the possible associated factors. MATERIAL AND METHODS: A total of 160 patients were enrolled in this retrospective study. Data on the following variables were collected from pre-and post-orthodontic treatment records: age, sex, Angle's malocclusion, facial pattern, number of activation sessions, compensatory treatment, and retreatment. Frontal, right and left lateral intraoral photographs of each patient were evaluated to identify the presence or absence of NCCLs in each tooth and assess the distribution of NCCLs in the 3840 teeth from the enrolled patients. Furthermore, patients were classified as NCCLs present, irrespective of the number of NCCLs on the teeth or NCCL absent. Bivariate and multivariate Poisson regression analyses with robust variance were used to assess the association between the NCCLs and each independent variable. Prevalence ratio and 95% confidence intervals were calculated and p < 0.05 was considered statistically significant. RESULTS: The prevalence of NCCLs before and after orthodontic treatment was 22.71% and 30.91%, respectively. Premolars were the most affected teeth, followed by the first molars, canines, and incisors. After statistical analysis, age was found to be the variable factor that influenced the prevalence ratio, with NCCL being the most prevalent when orthodontic treatment was performed in adulthood. CONCLUSIONS: Premolars were most commonly affected by NCCLs. Furthermore, age seemed to contribute to the increased prevalence of NCCLs in adults undergoing orthodontic treatment.

Effect of micro-osteoperforations on the gene expression profile of the periodontal ligament of orthodontically moved human teeth.

OBJECTIVES: This study aimed to evaluate the effect of micro-osteoperforations (MOPs) on the gene expression profile of the periodontal ligament (PDL) of orthodontically moved teeth. MATERIALS AND METHODS: Fifteen participants were randomly assigned into two groups: tooth movement only (Tr1, n = 7) and tooth movement supplemented with MOPs (Tr2, n = 8). In each subject, orthodontic tooth movement (OTM) was performed on premolar in one side, while no force was applied on contralateral premolar (Unt, n = 15). Seven days after loading, premolars were extracted for orthodontic reasons. RNA extraction from PDL and subsequent RNA-sequencing were performed. False discovery rates (Padj < 0.05) and log2 fold change (+ / - 1.5) thresholds were used to identify sets of differentially expressed genes (DEGs) among the groups. DEGs were analyzed with gene ontology enrichment, KEGG, and network analysis. RESULTS: Three hundred thirty-one DEGs were found between Tr1 and Unt, and 356 between Tr2 and Unt. Although, there were no significantly DEGs between Tr2 and Tr1, DEGs identified exclusively in Tr1 vs. Unt were different from those identified exclusively in Tr2 vs. Unt. In Tr1, genes were related to bone metabolism processes, such as osteoclast and osteoblast differentiation. In Tr2, genes were associated to inflammation processes, like inflammatory and immune responses, and cellular response to tumor necrosis factor. CONCLUSIONS: MOPs do not significantly alter the PDL gene expression profile of orthodontically moved human teeth. This study provides for the first time evidence on the whole PDL gene expression profiles associated to OTM in humans. Novel biomarkers for OTM are suggested for additional research. Clinical relevance The identified biomarkers provide new insights into the molecular mechanisms that would occur when OTM is supplemented with MOPs. These markers are expected to be useful in the near future for the application of personalized strategies related to the OTM.

Retração anterossuperior com utilização de mini-implante ­ relato de caso / Top anchor retraction with mini-implant use ­ case report

Resumo A biprotrusão apresenta-se com grande frequência na clínica ortodôntica e os pacientes, em sua maioria, são tratados através de exodontias dos primeiros pré-molares com retração da bateria anterior, permitindo uma retração do lábio superior e melhora na estética, harmonia facial e função. Nestes casos é importante uma ancoragem eficiente dos dentes posteriores, evitando a mesialização dos mesmos. O presente estudo possui como objetivo relatar um caso clínico de retração anterossuperior com utilização de mini-implante em um paciente com biprotusão dentária. Paciente do sexo masculino, melanoderma, 21 anos, apresentava Padrão Facial I de Capelozza, simetria facial, perfil convexo, protrusão da maxila, mandíbula e dos incisivos, Classe I de Angle, apinhamento anterior e ausências dentárias dos elementos 15 e 26. Durante o planejamento, optou-se pela exodontia dos primeiros pré-molares inferiores, alinhamento e nivelamento, retração em massa das baterias anteriores superiores e inferiores e a utilização de mini-implante na região superior posterior direita onde necessitaria de ancoragem absoluta. Entre as diversas formas de ancoragem, a utilização de mini-implante, de acordo com a bibliografia especializada, é uma das melhores opções, proporcionando um tratamento ortodôntico de qualidade, com ancoragem absoluta e menor tempo. Além disso, apresenta pequeno tamanho, o que facilita a instalação e remoção. As forças empenhadas são determinadas pelo ortodontista, recebem carga imediata, possuem estética, conforto e baixo custo. Outros métodos raramente permitem uma ancoragem máxima, além de apresentarem dificuldade de higienização, desconforto e dependem da colaboração do paciente.(AU)

Abstract Biprotrusion is very common in the orthodontic clinic. Most of these patients are treated by extractions of the first premolars with retraction of the anterior arcade, allowing retraction of superior lip and an improvement in aesthetics, facial harmony and function. In these cases, it is important to have an efficiently anchor for posterior teeth, avoiding mesialization. This study aims to report a clinical case of anterosuperior retraction using a mini-implant in a patient with dental biprotusion. Patient, melanoderma, 21 years old, male, facial Pattern I, facial symmetry, convex profile, maxilla, mandible and incisors protrusion, Angle Class I, anterior crowding, and tooth absences 15 and 26. During the planning, we opted for the extraction of the first inferior premolars, alignment and leveling, retraction of anterior teeth in superior and inferior arcade, and the use of mini-implants in the superior posterior right region where it would require absolute anchorage. Among the various forms of anchorage, the use of mini-implant, according to the specialized bibliography, is one of the best options, it leads a quality orthodontic treatment, absolute anchorage in a shorter period of time. In addition, they are small in size which facilitates installation and removal. The force applied is determined by the orthodontist, they receive immediate load, they have a good aesthetics, comfort and they have low cost. Other methods rarely allow maximum anchorage, and usually present difficulties in hygiene, discomfort, and depend on the patients collaboration (AU)

Miniparafusos extra-alveolares como ancoragem absoluta nas mecânicas ortodônticas modernas / Extra-alveolar mini-screws as absolute anchorage in modern orthodontic mechanics

Resumo Esta pesquisa busca demonstrar a utilização de sistemas de ancoragem absoluta focados na instalação extra-alveolar, principalmente, nas regiões conhecidas como prateleira bucal (buccal shelf-BC) e na crista infrazigomática (Infrazygomatic Crest-IZC). Através de pesquisas realizadas em portais especializados, como o Scielo e Google Scholar, selecionou-se uma série de artigos, periódicos, monografias e dissertações especializados na área. Verificando, principalmente através das pesquisas de Chang e Almeida, as principais áreas de instalação, o tamanho recomendado dos parafusos de acordo com o tipo de instalação, quais os métodos que proporcionam maior estabilidade ao parafuso, as principais indicações de uso, os benefícios incorridos no tratamento ortodôntico, assim como as contraindicações decorrentes do estado do paciente. Observando os diversos critérios elencados, pode-se verificar diversas vantagens dos miniparafusos extra-alveolares em relação aos intra-alveolares, principalmente, com relação à estabilidade decorrida pelo sistema extra-alveolar, permitindo o uso de parafusos com maior calibre sem afetar as raízes dentárias, podendo dessa maneira inclusive realizar a retração ou a mesialização de toda uma arcada, diminuindo sobremaneira as extrações dentárias e também corrigindo as divergências do plano oclusal. (AU)

Abstract This research aims to demonstrate the use of absolute anchoring systems focused on extra-alveolar installation, especially in regions known as buccal shelf-BC and infrazygomatic crest (IZC). Through research carried out in specialized portals, such as Scielo and Google Scholar, a series of articles, journals, monographs, and dissertations specialized in the area were selected. Checking, mainly through research of Chang and Almeida, the main installation areas, the recommended size of the screws according to the type of installation, which methods provide greater stability to the screw, the main indications of use, the benefits incurred to orthodontic treatment, as well as the contraindications resulting from the patient's condition. Observing the various criteria listed, several advantages of extra-alveolar mini-screws can be verified in relation to intra-alveolar screws, especially in relation to the stability eluded by the extra-alveolar system, allowing the use of screws with greater caliber without affecting the dental roots, thus being able to perform the retraction or mesyalization of an entire arch, reducing dental extractions in the way and also correcting the divergences of the occlusal plane.(AU)

Avaliação da resistência à deformação plástica dos fios redondos de níquel-titânio / Evaluation of plastic deformation resistance of nickeltitanium round wires

Resumo As ligas de níquel-titânio (NiTi) possuem elasticidade elevada sem sofrer deformações plásticas permanentes, sendo amplamente indicadas nas primeiras fases do tratamento ortodôntico. O Objetivo deste estudo é avaliar a resistência de fios ortodônticos de NiTi termoativados em relação à deformação plástica. Foram avaliados fios de 6 marcas comerciais (GAC®, Morelli®, American Orthodontics®, Infinity®e 3M®). Primeiramente a partir de modelos prototipados foi simulada a relação entre deformação plástica e deflexão pela distância interbráquetes em 4 níveis de força a 37°C por 30 dias. Um segundo experimento foi realizado através da análise de fotografias padronizadas com diagramas observando o antes e depois de aplicada uma deformação ao fio a diferentes temperaturas. Os resultados do primeiro teste mostraram que todas as marcas comerciais testadas retornaram a sua forma original após sofrer deflexão por 30 dias. O segundo experimento mostrou que os fios da marca GAC® e American Orthodontics® não apresentaram diferenças estatisticamente significativas comparando as medidas do fio antes da deformação, deformado e após aquecimento (fio aquecido). Já os fios das marcas 3M®, Orthometric® e Infinity®, Morelli apresentaram diferenças significantes entre os fios novos e os fios deformados, e entre os fios deformados e os fios aquecidos, porém, não houve diferenças significantes entre os fios novos e aquecidos. Concluiu-se que nenhum fio, em nenhuma magnitude de deflexão aplicada, sofreu deformação plástica (permanente). Assim, todos os fios das marcas comerciais testadas foram considerados satisfatórios para a prática clínica da Ortodontia no que diz respeito à resistência a deformação plástica. (AU)

Abstract Nickel-titanium (NiTi) alloys have high elasticity without suffering permanent plastic deformations, widely indicated in the early stages of orthodontic treatment. This study aims to evaluate the heat-activated NiTi orthodontic wires' resistance to plastic deformation. The wire from 6 commercial brands (GAC®, Morelli®, American Orthodontics®, Infinity®, and 3M®) was evaluated first from prototype models, simulating the relationship between plastic deformation and deflection by the inter bracket distance at four levels of force at 37° C for 30 days. A second experiment was carried out by analyzing standardized photographs with diagrams observing the before and after deformation was applied to the wire at different temperatures. The first test showed that all tested trademarks returned to their original shape after deflecting for 30 days. The second experiment showed that GAC® and American Orthodontics® wires did not present statistically significant differences comparing the wire measurements before deformed deformation and after heating (heated wire). On the other hand, 3M®, Orthometric® and Infinity®, Morelli wires showed significant differences between new and deformed wires and between twisted and heated wires; however, there were no significant differences between new and heated wires. It was concluded that no wire, at any magnitude of applied deflection, suffered plastic (permanent) deformation. Thus, all wires of the commercial brands tested were considered satisfactory for the clinical practice of Orthodontics in terms of resistance to plastic deformation.(AU)

Tratamento de má oclusão de classe III e mordida cruzada posterior bilateral através de camuflagem ortodôntica ­ relato de caso / Treatment of class III malocclusion and bilateral posterior crossbite through orthodontic camouflage ­ case report

Resumo A má oclusão de Classe III é caracterizada pela dimensão transversal insuficiente e as mordidas cruzadas são recorrentes nos pacientes com esse padrão esquelético. O objetivo deste trabalho é apresentar um caso clínico de tratamento Classe III e mordida cruzada posterior bilateral através de camuflagem ortodôntica. O paciente do sexo masculino, 18 anos e 7 meses, relatou como queixa principal a falta de oclusão entre os dentes superiores e inferiores. Apresentava má oclusão de Classe III, mordida cruzada posterior bilateral, desvio de linha média e assimetria facial. A correção da mordida cruzada foi realizada através da utilização de uma sequência de arcos ortodônticos superiores expandidos e arcos inferiores contraídos e a Classe III foi camuflada através da técnica Multiloop Edgewise Archwire (MEAW). Ao fim do tratamento, foi obtida a relação oclusal de Classe I entre os caninos, correção da mordida cruzada posterior bilateral e coincidência entre as linhas médias. A técnica MEAW mostrou eficácia na camuflagem da Classe III, assim como a sequência de arcos expandidos e contraídos na correção da mordida cruzada posterior bilateral. (AU)

Abstract Class III malocclusion is characterized by insufficient transverse size and crossbites are recurrent in patients with this skeletal pattern. The aim of this work is to present a clinical case treatment of Class III and bilateral posterior crossbite through orthodontic camouflage. Male patient, 18 years old and 7 months, reported as main complaint lack of occlusion between upper and lower teeth. He had Class III malocclusion, bilateral posterior crossbite, midline deviation, and facial asymmetry. Crossbite correction was performed using a sequence of expanded upper orthodontic arches and contracted lower arches and Class III camouflage by Multiloop Edgewise Archwire (MEAW) technique. At the end of treatment, it was obtained Class I occlusal relationship between canines, bilateral posterior crossbite correction and coincidence between the midlines. MEAW technique showed efficacy in Class III camouflage as well as the expanded and contracted arches sequence to correct bilateral posterior crossbite. (AU)

Tratamiento ortodóncico quirúrgico en un caso de inclusión bilateral de caninos superiores / Orthodontic surgical treatment in a patient with maxillary impacted canine teeth

RESUMEN Introducción: El tratamiento ortodóncico quirúrgico puede ser una terapia de elección para los caninos impactados, ya que estos deben conservarse en las arcadas por sus beneficios estéticos y funcionales. La inclusión bilateral de estos en el maxilar es menos frecuente y su tratamiento más complejo. Objetivo: Describir los resultados del tratamiento ortodóncico quirúrgico, en una paciente con inclusión bilateral de caninos superiores. Caso clínico: Paciente femenina de 16 años con antecedentes de salud, que acudió a consulta de Estomatología General Integral en compañía de la madre, preocupada por el aspecto de sus colmillos más blancos y pequeños. Al examen bucal, se observó una completa dentición permanente, excepto los caninos que, en su lugar, se encontraban los dientes 53 y 63. Presentó relieve anormal de la zona anterior de la mucosa palatina, con ligero aumento de volumen a la palpación. Se realizó radiografía panorámica y periapicales y se confirmó la presencia de ambos dientes impactados. Se realizó tratamiento ortodóncico quirúrgico. Conclusiones: El tratamiento ortodóncico quirúrgico devolvió a la paciente la función y la estética, mediante la correcta ubicación de ambos caninos en las arcadas.

ABSTRACT Introduction: Orthodontic surgical treatment could be a therapy of choice for the impacted canines, as they should be kept in the dental arches for their functional and aesthetic benefits. The bilateral impaction of these in the maxillary bone is less frequent and their treatment is more complex. Objective: To describe the results of the orthodontic surgical treatment in a female patient with bilateral impaction of upper canines. Case report: A 16-year-old female patient with a health history was assisted by a general dentist in the company of the mother, because she was worried about the aspect of her cupids which were whiter and littler. The oral examination showed the presence of a permanent and complete dentition with the exception of the upper canines, in their place, were teeth number 53 and 63. It was also found an abnormal relief in the anterior zone of the hard palate with a slight increase of volume at palpation. It was taken panoramic and periapical X-ray and it was confirmed the presence of both impacted teeth. It was made orthodontic surgical treatment. Conclusions: Orthodontic surgical treatment gave back the patient the function and aesthetic by means of the correct location of both teeth in the dental arches.

Tratamiento ortodóncicoquirúrgico de canino inferior derechotransmigrado / Orthodontic-surgical approach in the treatment of a transmigrated lower right canine

RESUMEN Introducción: Si un canino impactado cruza la línea media desde su posición normal al lado contrario, se denomina transmigración. Esta presenta bajos rangos de prevalencia por lo que se le considera una condición rara. El tratamiento ortodóncico quirúrgico es una de sus opciones terapéuticas. Objetivo: Describir los resultados del tratamientoortodóncico quirúrgico en un pacientecon canino inferior derecho transmigrado. Caso clínico: Paciente masculino de 11 años de edad con antecedentes de salud que acudió a consulta de Estomatología General Integral por tener los dientes botados y por la falta de uno que mudó y el sucesor aún no ha brotado. El caso se refiere al servicio de Ortodoncia. Al examen bucal destacó la ausencia clínica del 43, sin espacio necesario para su ubicación en la arcada. El paciente clasificó como síndrome de clase II división 1 de Moyers. Se indicó estudio radiográfico y se confirmó el diagnóstico de canino incluido, transmigrado y mesioangular en región mentoniana. Se decidió realizar tratamiento ortodóncico quirúrgico para colocar el canino en su posición. Conclusiones: El tratamiento ortodóncico quirúrgico devolvió al paciente la función y la estética, mediante la correcta ubicación del canino en la arcada. Este puede ser considerado como una alternativa terapéutica en el caso de canino mandibular transmigrado que presenta patrón tipo 1.

ABSTRACT Introduction: If an impacted canine tooth crosses the midline towards the opposite side, it is considered as dental transmigration. It is a rare condition with low ranges of prevalence. The surgical-orthodontic treatment is one of the therapeutic options. Objective: To describe the orthodontic-surgical treatment results, in a patient, with transmigrated lower right canine. Case report: An 11-year-old male patient attended the general practitioner for dental evaluation, his chief complaint was the absence of one deciduous tooth and the permanent still un-erupted and the tipping of the upper incisors. During the orthodontic examination was noted insufficient space to tooth 43 in the arch. The patient was diagnosed with Moyers' class II malocclusion division 1 syndrome. The radiographic examination confirmed the diagnosis of impacted and transmigrated lower right canine, mesioangular position across the midline within the chin area. Orthodontic-surgical treatment was carried out to bring the canine tooth to its functional position. Conclusions: Orthodontic-surgical treatment restored the function and aesthetics to the patient, through the right positioning of the canine in the arch. It could be considered as a therapeutic alternative in the case of transmigrated mandibular canine with type 1 pattern.