Outcomes of urethral meatal preservation ventral urethroplasty for female urethral stricture: a series of cases.

Objective: To present a series of cases with our initial experience and short-term outcomes of a modified vaginal mucosal flap urethroplasty. Methods: Patients diagnosed with urethral stricture and operated by the same operative technique between January 2012 and January 2018 were followed for at least 6 months. Uroflowmetry and clinical outcomes were evaluated. Results: Nineteen patients were included with an average age of 56.4 years, mean preoperative Qmax of 5.3 ml/s, and PVR of 101.4 mL. After 6 months of the procedure, the mean Qmax improved to 14.7 mL/s (p<0.05), PVR decreased to 47.3 mL (p<0.05), and 84.2% of all patients reported improvement in clinical self-reported symptoms. There was an improvement in symptoms such as voiding effort in 84.2% of patients, weak stream (89.5%), and recurrent urinary tract infection (85.7%). The success rate (absence of symptoms and normal Qmax with no significant PVR) of the procedure was 84.2%. Conclusion: The described technique was considered effective for the treatment of female urethra stricture, with a high clinical success rate and an objective improvement of Qmax and decrease in PVR after 6 months of the procedure.

Predictors of elaborated perineal or a combined abdominoperineal approach during repair for pelvic fracture urethral injury.

PURPOSE: A step-based anastomotic urethroplasty is a standard technique for repairing the posterior urethra in patients with pelvic fracture urethral injury (PFUI). We aim to identify pre-operative factors, including results of conventional radiological imaging, for prediction of elaborated perineal or a combined abdominoperineal procedure. METHODS: Retrospective observational study on 114 consecutive patients undergoing urethroplasty for PFUI between January 2020 and December 2022 was conducted. Surgical procedures were categorized according to the Webster classification into two groups: steps 1-2 (group 1) and steps 3-4 or a combined abdominoperineal repair (group 2). Pre-operative pattern results of RGU/VCUG were categorized regarding the relation between the proximal urethral stump with the pubic symphysis: posterior urethral stump below (pattern 1) or above (pattern 2) the lower margin of the pubic symphysis. Patient demographics were assessed. Univariate and multivariate logistic regression analyses were utilized. RESULTS: Overall, 102 patients were enrolled in the study for data analysis. On the multivariate logistic regression analysis, the presence of erectile dysfunction (OR 4.5; p = 0.014), prior combined treatment (endoscopic and urethroplasty) (OR 6.4; p = 0.018) and RGU/VCUG pattern 2 (OR 66; p < 0.001) significantly increased the likelihood of the need of step 3 or higher. CONCLUSIONS: The need of step 3 or higher during urethroplasty for PFUI can be predicted pre-operatively with conventional imaging (RGU/VCUG). Patients with proximal urethral stump above the lower margin of pubic symphysis were about 66 times more likely to need step 3 or higher during urethroplasty.

Outcomes of urethral meatal preservation ventral urethroplasty for female urethral stricture: a series of cases

Abstract Objective: To present a series of cases with our initial experience and short-term outcomes of a modified vaginal mucosal flap urethroplasty. Methods: Patients diagnosed with urethral stricture and operated by the same operative technique between January 2012 and January 2018 were followed for at least 6 months. Uroflowmetry and clinical outcomes were evaluated. Results: Nineteen patients were included with an average age of 56.4 years, mean preoperative Qmax of 5.3 ml/s, and PVR of 101.4 mL. After 6 months of the procedure, the mean Qmax improved to 14.7 mL/s (p<0.05), PVR decreased to 47.3 mL (p<0.05), and 84.2% of all patients reported improvement in clinical self-reported symptoms. There was an improvement in symptoms such as voiding effort in 84.2% of patients, weak stream (89.5%), and recurrent urinary tract infection (85.7%). The success rate (absence of symptoms and normal Qmax with no significant PVR) of the procedure was 84.2%. Conclusion: The described technique was considered effective for the treatment of female urethra stricture, with a high clinical success rate and an objective improvement of Qmax and decrease in PVR after 6 months of the procedure.

Smoking is an independent risk factor for stricture recurrence after the urethroplasty: a systematic review and meta-analysis

ABSTRACT Objective: To clarify the association between smoking and stricture recurrence after urethroplasty. Materials and Methods: Pubmed, Web of Science, Embase, and Cochrane databases were searched with keywords: "urethroplasty," "buccal mucosa graft urethroplasty," "oral mucosa graft urethroplasty," "excision and primary anastomosis urethroplasty," "urethral stricture recurrence" until July 1, 2022. Inclusion and exclusion criteria were based on PICOS principles. The quality of included studies was assessed by Newcastle-Ottawa Scale (N.O.S.) system. Hazard ratio (H.R.), odds ratio (OR), and relative risk (RR) with 95% confidence interval (CI) were extracted or re-calculated from included studies. Meta-analysis was performed with Stata 15.0 based on univariate and multivariate data separately. Sensitivity analysis was performed to test the stability of the meta-analysis. I2 was calculated to evaluate heterogeneity. Publication biases were assessed by Egger's and Begg's tests. Funnel plots of univariate analysis and multivariate analysis were also offered. Results: Twenty one studies with 6791 patients were involved in this meta-analysis. The analysis results of the two stages were consistent. In the univariate meta-analysis stage, 18 studies with 5811 patients were pooled, and the result indicated that smoking might promote stricture recurrence (RR=1.32, P=0.001). Based on the adjusted estimate, 11 studies with 3176 patients were pooled in the multivariate meta-analysis stage, and the result indicated that smoking might promote stricture recurrence (RR=1.35, P=0.049). There was no significant heterogeneity in both the univariate and multivariate stages. Conclusion: Our study demonstrates that smoking may prompt stricture recurrence after the urethroplasty. Quitting smoking may be a good option for patients undergoing urethroplasty surgery.

Smoking is an independent risk factor for stricture recurrence after the urethroplasty: a systematic review and meta-analysis.

OBJECTIVE: To clarify the association between smoking and stricture recurrence after urethroplasty. MATERIALS AND METHODS: Pubmed, Web of Science, Embase, and Cochrane databases were searched with keywords: "urethroplasty," "buccal mucosa graft urethroplasty," "oral mucosa graft urethroplasty," "excision and primary anastomosis urethroplasty," "urethral stricture recurrence" until July 1, 2022. Inclusion and exclusion criteria were based on PICOS principles. The quality of included studies was assessed by Newcastle-Ottawa Scale (N.O.S.) system. Hazard ratio (H.R.), odds ratio (OR), and relative risk (RR) with 95% confidence interval (CI) were extracted or re-calculated from included studies. Meta-analysis was performed with Stata 15.0 based on univariate and multivariate data separately. Sensitivity analysis was performed to test the stability of the meta-analysis. I2 was calculated to evaluate heterogeneity. Publication biases were assessed by Egger's and Begg's tests. Funnel plots of univariate analysis and multivariate analysis were also offered. RESULTS: Twenty one studies with 6791 patients were involved in this meta-analysis. The analysis results of the two stages were consistent. In the univariate meta-analysis stage, 18 studies with 5811 patients were pooled, and the result indicated that smoking might promote stricture recurrence (RR=1.32, P=0.001). Based on the adjusted estimate, 11 studies with 3176 patients were pooled in the multivariate meta-analysis stage, and the result indicated that smoking might promote stricture recurrence (RR=1.35, P=0.049). There was no significant heterogeneity in both the univariate and multivariate stages. CONCLUSION: Our study demonstrates that smoking may prompt stricture recurrence after the urethroplasty. Quitting smoking may be a good option for patients undergoing urethroplasty surgery.

Open surgery for urethral foreign body.

The introduction of foreign bodies in the urethra are uncommon. Given its rarity, the approach to this condition is not standardized but it is highlighted that minimally invasive procedures should be prioritized depending on its feasibility. In the present study, we report a case of a 60-year-old male patient with bipolar disorder and a foreign body impacted in the bulbar urethra with open surgical resolution after a failed endoscopic treatment. We perform an analysis into the diagnostic and therapeutic methods used, with postoperative results.

La introducción de cuerpos extraños uretrales es poco frecuente, razón por la cual, la mayoría de las publicaciones disponibles en la literatura son reportes de casos aislados o pequeñas series con gran heterogeneidad. Existen distintas aproximaciones frente a esta afección, desde métodos menos invasivos hasta cirugías abiertas más complejas. Presentamos un caso de cuerpo extraño impactado en uretra bulbar con el objetivo de analizar métodos diagnósticos empleados y aproximaciones terapéuticas concluyendo en la resolución quirúrgica convencional. Se evaluaron resultados postoperatorios.

Open surgery for urethral foreign body / Tratamiento quirúrgico convencional de cuerpo extraño uretral

Abstract The introduction of foreign bodies in the urethra are uncommon. Given its rarity, the approach to this condition is not standardized but it is highlighted that minimally invasive procedures should be prioritized depending on its feasibility. In the present study, we report a case of a 60-year-old male patient with bipolar disorder and a foreign body impacted in the bulbar urethra with open surgical resolution after a failed endoscopic treatment. We perform an analysis into the diagnostic and therapeutic methods used, with postopera tive results.

Resumen La introducción de cuerpos extraños uretrales es poco frecuente, razón por la cual, la mayoría de las publicaciones disponibles en la literatura son reportes de casos aislados o pequeñas series con gran heteroge neidad. Existen distintas aproximaciones frente a esta afección, desde métodos menos invasivos hasta cirugías abiertas más complejas. Presentamos un caso de cuerpo extraño impactado en uretra bulbar con el objetivo de analizar métodos diagnósticos empleados y aproximaciones terapéuticas concluyendo en la resolución quirúrgica convencional. Se evaluaron resultados postoperatorios.

Simplified urethral score system for predicting complex anterior urethroplasty.

OBJECTIVE: To assess U-score individual values as urethral complex surgery predictors. METHODS: Cross-sectional study including patients who received anterior urethroplasty from 2011 to 2019. U-score (etiology (1-2 points), number of strictures (1-2 points), anatomic location (1-2 points) and length (1-3 points)) was measured individually and globally. Surgical complexity was defined as low (anastomotic, buccal mucosal graft, and augmented anterior urethroplasty), and high complexity (double buccal mucosal graft, flap, and graft/flap combination). U-score components were included as complex surgery predictor and as main variable with individual probability values estimations and comparisons. Risk complex surgery probability groups were established. RESULTS: 654 patients were included. Mean age was 57.2 years. Low complexity surgery was performed in 464 patients (259 anastomotic, 144 graft, 61 augmented anterior urethroplasty) and high complexity was done in 190 (53 double buccal mucosa graft, 27 flap, 110 graft/flap comb.). In multivariate analysis length, number of strictures and location were predictors of complexity. Introducing U-Score as only variable in univariate model predicted an OR 8.52 (95%CI 6.1-11). Simplified U-score grouping set obtained by complex probability was: low risk (4-5 points), medium risk (6 points) and high risk of complexity (7-9 points) Predicted risk of complex surgery probability (95%CI) for low, median and high risk group were 1.6 (0-2.9), 19.1 (13.8-25.9) and 77.9 (61.6-88.7), respectively. CONCLUSIONS: U-score can be used as a tool to predict complex urethral surgery. We present a simplified U-score risk tool to assess individual complex anterior urethroplasty probability.

Risk factors associated with urethral stricture recurrence after end-to-end urethroplasty and buccal mucosal graft urethroplasty.

OBJECTIVES: (1) Assess risk factors associated with urethral stricture recurrence (USR). (2) Assess urethral stricture recurrence after end-to-end urethroplasty (EE) and buccal mucosal graft urethroplasty (BMG). SUBJECTS AND METHODS: A total of 29 males with urethral stricture who underwent either an end-to-end urethroplasty or a buccal mucosal graft urethroplasty were included in this study and followed for 18 months. The association between risk factors and stricture recurrence was assessed. RESULTS: Overall mean patient age was 51.69 ± 14.22 years, time to recurrence was 3 months (IQR: 1-6.25), and stricture length was 2.57 ± 1.30 cm. Important risk factors for USR were stricture length ⩾ 2 cm (p = 0.024), older age (p = 0.042), BMI > 25 kg/m2 (p = 0.021), Qmax after catheter removal <15 ml/s (χ2 = 14.87 p ⩽ <0.001) and previous urethral procedures adjusted for re-do BMG urethroplasty (χ2 = 6.10, p = 0.021). End-to-end urethroplasty showed less USR than BMG, however, these differences were not statistically significant (41.6% vs 22.2%, respectively, p ⩾ 0.05). CONCLUSIONS: Stricture length, age, BMI, and previous urethral procedures predict USR, furthermore, an initial Qmax after catheter removal is an objective measure predictive of USR. There's no difference in USR rate between BMG and EE urethroplasties.

Safety and efficacy of urethroplasty based on age groups.

OBJECTIVE: To analyze the results and complications after urethroplasty based on patient age groups. As secondary objective, we analyzed the impact of operative complexity on each age group. MATERIAL AND METHODS: This is a retrospective cohort study that include male patients who underwent urethroplasty between January 2011 and December 2018. Data was obtained from the patients' electronic health records. Patients were grouped as follows: <60 years, 60-79 years and >80 years. Variables evaluated were history, comorbidities, previous surgeries and operative complexity. Restenosis-free survival and complications presented in each group were determined according to the Clavien-Dindo classification system. The SPSS® program was used for statistical analysis. RESULTS: A total of 783 patients were included, and the mean follow-up was 19 months. The estimated 2-year restenosis-free survival in the population under 60, 60-79 and over 80 years was 87, 87 and 93.9% (IC 95%), respectively. Univariate analysis showed that the age group was not a predictor of restenosis. Complex surgery is the only predictor of recurrence, increasing the risk by 60% (HR 1.64, 95% CI 1.05-2.56, p = 0.029). There was an overall complication rate of 30.8%, and 62% of these were Clavien ≤ II. We found no association between the frequency of complications and age. CONCLUSIONS: Urethroplasty is safe and effective regardless of age group. There are no statistically significant differences in outcomes and complications shown by the age group comparison. There were no significant differences when analyzing the impact of complex surgeries among the different age groups. The data indicate that age alone should not be taken as an absolute exclusion criterion for patients needing urethral reconstruction.

A different approach to distal hypospadias repair: The GUD (glandular urethral disassembly) technique.

INTRODUCTION: Distal hypospadias represent the most frequent clinical presentation of hypospadias. In spite of more than 300 techniques available, there is not an ideal approach. We have proposed an alternative procedure based on the combination of minor urethral mobilization and major glans deconstruction and partial disassembly from the corpora, the GUD technique. We want to present our clinical experience with the procedure and describe it in detail. METHODS: The technique consists of disconnecting the spongious tissue and the distal urethra from the corpora and detaching partially the glans as well, from 2 to 10 o'clock. The glans is opened in midline and the procedure combines cranially mobilization of urethra with caudal and medial rotation of glans wings to refurbish the glans correcting the hypospadia without urethroplasty. RESULTS: We have treated 164 patients with distal hypospadia. Median age at the surgery was 22.4 months (1-184 months). The meatal position after penile degloving was coronal at 108 cases, subcoronal at 54 and 2 patients presented megameatus and intact foreskin. Three patients (1.8%) had mild penoscrotal transposition in addition to hypospadia. Twenty-eight patients were treated as a secondary repair (17%). We found complications in 6 patients (3.6%) consisting of five fistulas (3%) and three glans dehiscence (1.8%). Two patients had both complications. Follow up was 21 months (1-42 months) and the median follow-up time was 18 months. DISCUSSION: We acknowledge that this procedure is intended only to distal hypospadias (coronal and subcoronal). We stress that the GUD procedure can be performed irrespectively of any urethral plate "quality" as it does not require a minimum glans width as the TIP repair. Moreover, there is no need for preoperative testosterone treatment. The absence of suture and urethroplasty minimizes the risk of coronal fistulas after surgery. CONCLUSIONS: We believe that this procedure is a viable alternative to distal hypospadias repair.

Uretroplasty with oral mucosal graft in patients with anterior urethral stenosis. Comparative study with conventional treatment.

ANTECEDENTES: El manejo con uretroplastía de la estenosis uretral es una opción quirúrgica fundamental, y comparar la uretroplastía con injerto de mucosa oral con la uretroplastía término-terminal tiene trascendencia para conocer la diferencia entre ambas técnicas. OBJETIVO: Comparar la uretroplastía con injerto de mucosa oral con la uretroplastía término-terminal en pacientes con estenosis uretral tipo Jordan C, D y E. MÉTODO: Cuasiexperimento realizado en pacientes con estenosis uretral anterior operados de uretroplastía con anastomosis término-terminal o con injerto de mucosa bucal. RESULTADOS: Veintinueve pacientes con una media de edad de 50.7 años, 6 diabéticos, 9 hipertensos, longitud media de la estenosis de 3.6 cm, 19 operados con uretroplastía termino-terminal (grupo 1) y uretroplastía con mucosa bucal (grupo 2). El Índice Internacional de Síntomas Prostáticos promedio preoperatorio fue grave en la mayoría de los pacientes (93%). Hubo mejoría significativa en el posoperatorio en ambos grupos (p = 0.0001 y p = 0.0011), así como en los resultados uroflujométricos (p = 0.0046 y p = 0.00062). CONCLUSIONES: Ambos procedimientos lograron mejorías significativas en la sintomatología urinaria a los 6 meses en comparación con los valores preoperatorios. BACKGROUND: Urethroplasty management of urethral stricture is a fundamental surgical option, and comparing urethroplasty with oral mucosal graft with end-to-end urethroplasty is important to know the difference between both techniques. OBJECTIVE: To compare urethroplasty with oral mucosal graft with end-to-end urethroplasty in patients with urethral stricture type Jordan C, D and E. METHOD: Quasi-experiment performed in patients with anterior urethral stricture operated with urethroplasty with end-to-end anastomosis or with oral mucosal graft. RESULTS: Twenty-nine patients with a mean age of 50.7 years, 6 diabetic, 9 hypertensive, mean stenosis length of 3.6 cm, 10 with end-to-end urethroplasty (group 1) and 19 operated with urethroplasty with buccal mucosa (group 2). The average preoperative International Prostatic Symptom Index was severe in most patients (93%). There was significant improvement postoperatively in both groups (p = 0.0001 and p = 0.0011), as well as in uroflowmetric results (p = 0.0046 and p = 0.00062). CONCLUSIONS: Both procedures achieved significant improvements in urinary symptomatology at 6 months compared to preoperative values.

Complicaciones en posoperatorio inmediato de cirugía uretral anterior; ¿existe relación con la recaída? / Early complications in urethral anterior surgery; is there any relationship with recurrence?

INTRODUCCIÓN/OBJETIVO: La estrechez uretral puede causar síntomas miccionales, dolor, disfunción vesical y eyaculatoria. La tasa de complicaciones en uretroplastía anterior es baja. El principal objetivo es evaluar complicaciones del posoperatorio (pop) inmediato (dentro de los 30 días pop). El objetivo secundario es valorar la relación entre complicaciones y la tasa de recaída. MATERIALES Y MÉTODO: Se realizó una revisión retrospectiva de las uretroplastías anteriores realizadas entre octubre del 2012 y junio del 2017. Se valoró: reinternación, reingreso a cirugía, infarto agudo de miocardio, tromboembolismo de pulmón, trombosis venosa profunda, óbito, infecciones, dehiscencia de herida, hematomas, sangrados, etc. Se definió recaída a la necesidad de realizar cualquier instrumentación uretral secundaria a la uretroplastía. Las variables se analizaron estadísticamente con Chi square y Mann-Whitney U test. RESULTADOS: Se incluyeron 92 pacientes, con un seguimiento mínimo de 12 meses. Las edades fueron de 18 a 88 años (mediana, 61,5 años). En 58 pacientes, se utilizaron transferencia de tejidos (27 injertos y 31 colgajos). La longitud de la estrechez fue desde 1-15 cm (media, 3,25 cm). La iatrogénica (56%) fue la etiología más frecuente. 56 pacientes (63%) tenían tratamientos previos. La tasa de complicaciones pop inmediato fue del 32%, las infecciones fueron las más frecuentes. Según Clavien, se clasificaron: I: 40%; II: 47%; III: 10%; IV: 3%. Hubo 17 recaídas (18%), 13 dentro de los primeros 6 meses del pop. De los pacientes que presentaron complicaciones, recayó el 23%; solo 16% de los que no las presentaron (p: 0,4). Aquellos pacientes con complicaciones graves presentaron mayor tasa de recaída (p: 0,2). CONCLUSIÓN: La tasa de complicaciones pop inmediata de uretroplastía anterior fue de 32%; las infecciones fueron las más frecuentes. La mayoría fue Clavien I y II. La recaída fue mayor en aquellos pacientes que sufrieron complicaciones en pop inmediato.

INTRODUCCION/OBJECTIVE: Urethral stenosis can cause mictional symptoms, pain, bladder dysfunction and ejaculatory problems. Complications rate in anterior urethroplasty is low. Main objetive is to evaluate early post operatory complications Secondary objetive is to assess the relationship between complications and recurrence rate. MATERIALS AND METHODS: We performed a restrospective review of our anterior urethroplasty database between October 2012 and June 2017. We recorded: patients readmission, return to operating room, acute myocardial infarction, pulmonary embolism, deep venous thrombosis, death, infections, wound dehiscense, hematomas, bleedings, etc. We defined recurrence as any urethral instrumentation after urethroplasty. Variables were analyzed using Chi Square and Mann Whitney U test. RESULTS: 92 patients were included in the study with at least 12 months follow up. Age range was between 18-88 years. (median 61,5 years) Substitution urethroplasty were performed in 58 patients (grafts 27 and flaps 31) Urethral stenosis lenght range was between 1 and 15 cm (mean 3,25cm) Most frequent cause of urethral stenosis was iatrogenic (56%) 56 patients underwent previous treatment (63%) Complication rate in early post operative period was 32%, most of them infections. Clavien clasiffication: I: 40%; II: 47%; III: 10%; IV: 3%. There were 17 recurrences (18%), 13 during the first 6 months after surgery. 23 % of patients with complications had recurrence and only 16% of patients without, had recurrence (p:0,4) Patients with serious complications had greater recurrence rate (p: 0,2) CONCLUSION: Recurrence rate in early complications of anterior urethroplasty was 32%, most of them infections. Clavien I and II are the most frequent. Recurrence was greater in patients who suffered early complications

Safety and efficacy of urethroplasty based on age groups. / Seguridad y eficacia de la uretroplastia según grupos etarios.

OBJECTIVE: To analyze the results and complications after urethroplasty based on patient age groups. As secondary objective, we analyzed the impact of operative complexity on each age group. MATERIAL AND METHODS: This is a retrospective cohort study that include male patients who underwent urethroplasty between January 2011 and December 2018. Data was obtained from the patients' electronic health records. Patients were grouped as follows: < 60 years, 60-79 years and > 80 years. Variables evaluated were history, comorbidities, previous surgeries and operative complexity. Restenosis-free survival and complications presented in each group were determined according to the Clavien-Dindo classification system. The SPSS® program was used for statistical analysis. RESULTS: A total of 783 patients were included, and the mean follow-up was 19 months. The estimated 2-year restenosis-free survival in the population under 60, 60-79 and over 80 years was 87, 87 and 93.9% (IC 95%), respectively. Univariate analysis showed that the age group was not a predictor of restenosis. Complex surgery is the only predictor of recurrence, increasing the risk by 60% (HR 1.64, 95% CI 1.05-2.56, p = 0.029). There was an overall complication rate of 30.8%, and 62% of these were Clavien ≤ II. We found no association between the frequency of complications and age. CONCLUSIONS: Urethroplasty is safe and effective regardless of age group. There are no statistically significant differences in outcomes and complications shown by the age group comparison. There were no significant differences when analyzing the impact of complex surgeries among the different age groups. The data indicate that age alone should not be taken as an absolute exclusion criterion for patients needing urethral reconstruction.

Postoperative urinary extravasation does not impact anterior urethroplasty surgical outcomes: a Latin American large cohort study.

OBJECTIVE: To determine the prevalence of postoperative urinary extravasation (POUE) following anterior urethroplasty, to analyze factors associated with its occurrence, and to study the impact of POUE on surgical success. MATERIALS AND METHODS: Retrospective cohort study including all male patients who have undergone a urethroplasty at our center between 2011 and 2018. Subjects with posterior location stricture, those who did not undergo routine radiographic follow-up, or patients with inadequate follow-up were excluded. Urinary extravasation was defined as presence of evident contrast extravasation on the postoperative voiding cystourethrogram (VCUG). Impact was determined as "need-for-reoperation". Uni- and multivariate analysis were performed to determine clinical and demographic variables associated with occurrence of extravasation and postoperative stricture. RESULTS: A total of 783 men underwent a urethroplasty and 630 fulfilled inclusion criteria. Urinary extravasation prevalence was 12.2%, and there was a "need-for-reoperation" in 1.1% of cases. On uni- and multivariate analysis, greatest stricture length (HR: 1.07 (1-1.2), p = 0.05) and penile urethral location (HR: 2.29 (1.1-4.6), p = 0.021) showed to be POUE predictors. POUE did not show to be a risk factor for postoperative stricture (HR: 1.57, 95% CI (0.8-3), p = 0.173). However, reoperation group  showed to be a risk factor (HR: 6.6, 95% CI 1.4-31, p = 0.019). CONCLUSIONS: Prevalence of POUE was 12.2%. Stricture length and penile urethral strictures were POUE predictors. POUE occurrence with successful conservative management did not appear to have impact on urethroplasty outcomes as it did not predict re-stricture. POUE was reoperation cause in 1.1% of total cases.

Female urethral reconstruction: dorsal buccal mucosa graft onlay.

PURPOSE: Female urethral stricture (FUS) is an infrequent entity, but may cause significant morbidity. Despite a rising interest in recent years, there is still scarce published information. In this article, we review FUS with a special attention to the use of dorsal buccal mucosa grafts (DBMG). METHODS: A literature search was conducted summarizing information about etiology, anatomy, diagnosis, and management. A detailed description of our technique for DBMG urethroplasty is given, with a summary report of our experience and results. RESULTS: FUS accounts for about 1% of all women consulting for lower urinary tract symptoms (LUTS). Diagnosis is suspected in front of persistent LUTS suggestive of obstruction. Confirmatory tests are uroflowmetry, endoscopy, and urethrography; true anatomic strictures must be differentiated from functional or physiological obstructions. Initial management may include dilations, but recurrence is frequent. On the contrary, reconstructive surgery is highly efficient, with overall curative rates around 90%. For reconstruction, DBMG has gained popularity, because it would maintain intact the ventro-lateral urethral supporting structures, important for continence. The pathology of female strictures is unknown and neither the pre nor the intraoperative assessment allows determining the precise location and extent or the urethral damage; therefore, we advise extensive grafting of the entire urethra. Collected success of DBMG is 86% at a mean follow-up of 21 months. Morbidity is very low and de novo stress incontinence has not been reported. CONCLUSIONS: Because of its many advantages, DMBG currently represents a prime choice for FUS reconstruction.

Anatomy and techniques in posterior urethroplasty.

Given its complex anatomy, injury to the posterior urethra may result in a number of reconstructive challenges. With the appropriate operative planning and experience, surgical repair can be very successful. This review discusses the applicable techniques for the perineal approach to posterior urethral stenosis, including bulbomembranous anastomosis for pelvic fracture urethral injury and repair of vesicourethral anastomotic stenosis (VUAS) following prostate surgery. The advanced techniques reviewed include an adaptation allowing a bulbar artery sparing approach to posterior urethroplasty and an intrasphincteric urethroplasty procedure which may allow continence preservation in patients with membranous urethral stenosis.

Tratamiento Quirúrgico de la estenosis bulbomembranosa secundaria a fractura pelviana: resultados funcionales / Bulbomenbranous Urethral Stricture After Pelvic Fracture: Surgical Managment and Functional Outcomes

Objetivos: La incidencia de lesión uretral bulboprostática secundaria a fractura pelviana es del 5-10%. Una uretroplastia exitosa garantiza el comienzo de la rehabilitación de los pacientes. Presentamos nuestra experiencia en el manejo quirúrgico de la estenosis uretral secundaria a fractura pelviana y resultados funcionales: tasa de éxito, reestenosis, disfunción eréctil e incontinencia urinaria. Evaluamos si existe asociación entre la falta de erecciones postrauma y la reestenosis. Materiales y métodos: Cincuenta y tres pacientes fueron operados durante el período comprendido entre 2001 y 2015. Todos fueron estudiados con cistoscopia flexible, cistouretrografía retrógrada y miccional. La técnica quirúrgica empleada fue la resección y anastomosis primaria. Se utilizó siempre la sistemática del abordaje perineal progresivo para lograr una anastomosis sin tensión. Interrogamos sobre la calidad de las erecciones posterior al trauma y después de la cirugía, y su estado de continencia urinaria. Se realizó un análisis estadístico donde se evaluó si la falta de erecciones era un factor de riesgo para recaída. Resultados: La edad promedio de los pacientes fue de 34,5 (r=17-67) años. La longitud promedio de la estenosis fue de 2,28 cm, siendo la uretra bulbomembranosa la más afectada (89%). La tasa de éxito fue del 86% (46/53), que asciende al 94% (50/53) al asociar un procedimiento endoscópico. Un solo paciente refirió disfunción eréctil postcirugía (1/19; 5,3%). Dos (3,7%) pacientes evolucionaron con incontinencia de orina de esfuerzo. No se hallaron diferencias estadísticamente significativas entre el grupo de pacientes con erecciones y aquellos sin erecciones en cuanto a la posibilidad de reestenosis. Conclusiones: La anastomosis bulbomembranosa por vía perineal es el tratamiento de elección de la estenosis uretral postfractura pelviana. Los índices de incontinencia de orina y disfunción eréctil no aumentan significativamente luego de la uretroplastia. En nuestra experiencia, la falta de erecciones preoperatoria no predice mayor índice de recaídas(AU)

Objectives: Bulboprostatic urethral stricture after pelvic fracture occurs in about 5-10%. A successful urethroplasty guarantees the beginning of patient recovery. We present our experience in the surgical management of posterior urethral stricture after pelvic fracture and functional outcomes (success and failure rates, erectile dysfunction and urinary incontinence). The association between the lack of erections post-trauma and the incidence of restenosis was also evaluated. Materials and methods: 53 patients were operated between 2001- 2015. Preop workout included a flexible cystoscopy and a combination of retrograde and voiding cystourethrogram to define the site and length of urethral stricture. Resection and primary anastomosis was the technique always employed. In all cases the progressive perineal approach was followed in order to achieve a tension free anastomosis. Erectile function and urinary continence were evaluated before and after surgery. Statistical analysis was performed to evaluate if lack of erections was a failure predictor. Results: Median age was 34.5 (r=17-67) years. Median urethral stricture length was 2.28 cm. Bulbomembranous junction was the most affected portion (89%). Success rate was 86% (46/53) ascending to 94% (50/53) when an endoscopic procedure was associated. One patient referred erectile dysfunction after surgery (1/19; 5.3%). Two patients (3.7%) developed stress urinary incontinence. The restenosis rate did not show statiscally differences between the erectile dysfunction and non-erectile dysfunction group. Conclusions: Perineal bulbomembranous anastomosis is the elected procedure for urethral stricture after pelvic fracture. Incidence of urinary incontinence and erectile dysfunction are not significantly elevated after urethroplasty. In our experience, lack of erections before surgery does not predict a higher rate of restenosis(AU)

Estrechez de uretra bulbopeneana de 16 centímetros, ¿es posible resolverla en un sólo tiempo? / 16-centimeter Penile Bulbar Urethral Stricture: Can it be Solved in Only One Stage?

La panestenosis de la uretra anterior tradicionalmente se ha resuelto mediante la uretroplastía en etapas. Esto implica un grave deterioro en la calidad de vida del paciente, ya que debe permanecer con la uretra expuesta y orinando sentado por unos 2 a 6 meses, entre las cirugías. Nuestro objetivo es detallar una técnica alternativa. Materiales y métodos: Presentamos un paciente de 60 años, con antecedentes de uropatía obstructiva baja de larga data, sin estudio previo. Durante una hospitalización para recambio valvular aórtico, presenta una retención aguda de orina. El sondeo uretral resulta frustro y debe instalarse una cistostomía. Posteriormente, se estudia con cistouretroscopía retrógrada y anterógrada flexible, encontrándose estrecheces en uretras peneana y bulbar, además de extensa espongiofibrosis. La uretrocistografía confirma una panestenosis anterior y muestra una uretra posterior indemne. Se decide resolver mediante uretroplastía con técnica de Asopa, utilizando un abordaje ventral, con injerto doble de mucosa oral, dispuesto en inlay dorsal, en un solo tiempo. Con bisturí oftálmico, se realiza una amplia y profunda uretrotomía dorsal, donde se fijarán los injertos más adelante. Simultáneamente, otro equipo cosecha la mucosa oral de ambas mejillas y prepara los injertos. Estos se fijan con sutura corrida en todos sus extremos y, mediante puntos interrumpidos, a la línea media sobre la albugínea dorsal. Una vez que los injertos están fijos, se instala una sonda foley siliconada de 16Fr y se procede a realizar la uretrorrafia del abordaje ventral, sobre la sonda. Finalmente se procede al cierre del cuerpo esponjoso, músculo bulboesponjoso, fascia de Colles, tejido subcutáneo y piel. Resultados: No hubo complicaciones intraoperatorias ni postoperatorias. El paciente se dio de alta a sudomicilio a los 4 días postoperatorios. La sonda se mantuvo por 34 días en total y se retiró previa realización de una pericateterografía. A los 6 meses de seguimiento, tiene un IPSS=5 y un Qmax de 17ml/seg. Conclusiones: Es factible y seguro resolver una panestenosis de uretra anterior, de 16 centímetros, mediante la técnica de Asopa, en un solo tiempo.

The pananterior urethral strictures has traditionally been solved by urethroplasty in stages. This implies serious deterioration in the life quality of patients, since the patient's urethra must remain exposed and urination must take place in a sitting position for 2 to 6 months between surgeries. Our goal is to detail an alternative technique. Materials and methods: We present a 60-year old patient with a history of long-standing lower obstructive uropathy with no previous study. During hospitalization for aortic valve replacement, he exhibits acute urinary retention. Urethral sounding is unsuccessful and cystotomy must performed. Later, he is subject to a flexible retrograde and antegrade cystourethroscopy study, finding a strictured penile and bulbar urethra, plus extensive spongiofibrosis. Urethrocystography confirms pananterior stenosis and shows an unscathed posterior urethra. It was decided to resolve the condition by urethroplasty with Asopa technique, using a ventral approach, with oral mucosa double graft, placed in a one-stage dorsal inlay. An ophthalmic scalpel is used to perform a broad and deep dorsal urethrotomy, where the grafts will be later placed. Simultaneously, another team harvest the oral mucosa from both cheeks and prepares the grafts. The latter are fastened with running suture in all ends and by interrupted stitches to the midline on the dorsal tunica albuginea. Once the grafts are fastened, a 16Fr silicone Foley catheter is installed and uretrorraphy is performed by ventral approach over the catheter. Finally, the spongy body, bulbospongiosus muscle, Colles' fascia, subcutaneous tissue and skin are closed. Results: There were no intraoperative or postoperative complications. The patient was discharged 4 days after surgery. The catheter was maintained for 34 days in total and removed after pericatheterogram. On the 6-months follow-up, it presents IPSS = 5 and Qmax of 17ml / sec. Conclusions: It is feasible and safe to resolve a pananterior urethral stenosis of 16 centimeters, using the technique of Asopa in one stage.

Uretroplastía: experiencia del servicio de urología del Hospital Regional de Talca / Urethroplasty: experience of urology of the regional Hospital of Talca

Analizar en forma retrospectiva nuestros resultados con uretroplastías en 2 grupos según la técnica utilizada. MATERIAL Y MÉTODO: En el periodo 1997-2012 se efectuaron 58 Uretroplastías, 32 de sustitución (grupo 1) en los que se utilizó principalmente colgajo de piel de pene (77 por ciento) y 26 Uretroplastías anastomóticas (grupo 2). Motivo de análisis son 30 y 24 casos respectivamente. Un buen resultado se definió por un factor subjetivo (relato del paciente), Flujometría igual o mayor de 10 ml/seg. c/s IPSS igual o < 9.RESULTADOS: En el grupo 1 el 77 por ciento la lesión era >4 cm y con 83 por ciento de buenos resultados a una mediana de seguimiento de 41meses. El 23 por ciento, requirió procedimientos complementarios. El 61 por ciento tuvo algún compromiso de vascularización de piel de pene. En el grupo 2 el 46 por ciento fue por fractura de pelvis con una tasa de buenos resultados de 92 por ciento con una mediana de seguimiento de 25.5 meses, 21 por ciento de procedimientos complementarios de retoque y sin complicaciones. CONCLUSIONES: Nuestra serie tiene resultados comparables con lo publicados en la literatura.

Throughout this study the researcher(s) personal experience in urethroplasty during the period 1997-2012 was analyzed. To conduct it, the studied cases were divided into two different groups; the first group were 30 cases of substitution urethroplasty with a forty-one-months median follow-up, where the success rate was 83 percent. The most frequent complications were impairment of vascular supply of the penile skin secondary the use of distal penile circular fascio cutaneus flap(61 percent). The second group (group nº2) was composed by 24 cases of anastomotic urethroplasty with a median follow-up of 25,5 months, in this group the success rate was 92 percent and no complications were observed. After this study, it is possible to assert that the obtained results are in concordance with what is stated in the international literature.