RESUMEN
Five patients with active seronegative, rheumatoid arthritis, HLA-DR3 negative, received inadvertently 250 to 500 mg of aurothioglucose instead of their usual weekly dose, during standard remission-inducing chrysotherapy. Subsequently a rapid and sustained clinical remission appeared in all five patients.
Asunto(s)
Artritis Reumatoide/tratamiento farmacológico , Aurotioglucosa/envenenamiento , Oro/envenenamiento , Errores de Medicación , Adulto , Anciano , Anciano de 80 o más Años , Aurotioglucosa/administración & dosificación , Esquema de Medicación , Femenino , Humanos , Inyecciones Intramusculares , Masculino , Persona de Mediana Edad , Inducción de RemisiónRESUMEN
A patient with rheumatoid arthritis developed gold induced peripheral neuropathy after 255 mgs of aurothioglucose. This neuropathy is characterized by weakness and numbness of the hands and feet in association with hyperalgesia of the palmar surface of the hands. The absence of vasculitis permits differentiation of gold neuropathy from the neuritis associated with rheumatoid arthritis or systemic lupus erythematosus. Treatment consists in cessation of gold and possibly the use of dimercaprol; recovery is slow but generally complete.
