Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 6.496
Filtrar
1.
Dermatol Online J ; 30(2)2024 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-38959932

RESUMEN

Porokeratosis is a skin condition that involves the formation of plaques, characterized by a hyperkeratotic ridge with an atrophic center. There is a histological presence of a cornoid lamella, which is a parakeratotic column that traverses through the stratum corneum. The plaques are mostly benign but have the potential to become squamous cell carcinomas if left untreated. Porokeratosis lesions typically occur on the extremities, but they can develop anywhere. The occurrence of porokeratosis on the lip is exceedingly rare. We report three cases of porokeratosis on the lip. Each incidence was treated with cryotherapy, which was unsuccessful in two. One of these two patients did not elect for topical treatment and is being monitored for lesion changes. The second patient was successfully treated via shave biopsy. The third patient was lost to follow-up post-cryotherapy.


Asunto(s)
Poroqueratosis , Humanos , Poroqueratosis/patología , Poroqueratosis/diagnóstico , Masculino , Persona de Mediana Edad , Femenino , Crioterapia , Enfermedades de los Labios/patología , Enfermedades de los Labios/diagnóstico , Adulto , Anciano , Biopsia
2.
PLoS One ; 19(7): e0306889, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38995898

RESUMEN

Even when pain control is implemented, calves may experience pain for days after hot-iron disbudding. Whether calves seek pain relief post-disbudding offers a novel approach to assessing pain in these animals. By employing an approach-aversion paradigm, we explored the ability of cold therapy to provide immediate pain relief in disbudded calves. Calves were habituated to the manual placement of a cool or ambient pack on their forehead for a short duration simultaneous to milk reward consumption, prior to disbudding. Calves were then disbudded under local anaesthesia (procaine) and analgesia (meloxicam), and responses to the packs were observed over subsequent days. Individual calves were consistently exposed to either cool or ambient packs in different halves of a two-sided experimental pen, allowing for the testing of approach-aversion and conditioned place preference. We found calves approached milk rewards quicker and maintained contact for longer when receiving cold therapy compared to the ambient control. However, calves did not display any conditioned preference for the pen where they received the cool pack. These results add to the growing evidence of lasting pain following disbudding procedures and suggests that cold therapy provides some form of pain relief post-disbudding. Future studies should seek other ways to use cold therapy post-disbudding to reduce aversiveness and human involvement.


Asunto(s)
Cuernos , Manejo del Dolor , Animales , Bovinos , Cuernos/cirugía , Manejo del Dolor/métodos , Crioterapia/métodos , Crioterapia/veterinaria , Dolor , Femenino , Frío , Industria Lechera
3.
Arch Dermatol Res ; 316(7): 471, 2024 Jul 13.
Artículo en Inglés | MEDLINE | ID: mdl-39001899

RESUMEN

Congenital epidermodysplasia verruciformis (CEV) is a Genodermatosis linked to different inheritance patterns and mutations of the EVER1/TMC6 and EVER2/TMC8 genes. There is an acquired form (AEV) associated with immunodeficiency states, including human immunodeficiency virus (HIV) infection; however, the literature about AEV is limited and imprecise, so a systematic review was performed. A search of the main databases from 1975 to 2021 identified 126 studies, of which 80 met the inclusion criteria. The diagnosis of AEV is complex due to atypical manifestations and locations, it requires a mean follow-up of 7 years, and the lesions do not change with ART therapy, CD4 count, or viral load. Histopathological findings are variable depending on the location of the lesions. HPV 5 remains the serotype most frequently associated with AEV and CEV, although HPV 20 is more frequent than HPV 8 in AEV. Most treatments have low efficacy, the most described are glycolic acid 15%, 5-fluorouracil 5%, imiquimod 5%, and topical retinoids all of them in monotherapy or combined with cryotherapy. Other alternatives include topical cidofovir and systemic retinoids with variable results. The oncologic prognosis is still inconclusive; however, the development of squamous cell carcinoma and melanoma are frankly lower concerning CEV. This review opens new opportunities for future research. Additionally, we provide clear and useful key points for the practice of dermatologists and all professionals treating HIV patients around the world.


Asunto(s)
Epidermodisplasia Verruciforme , Infecciones por VIH , Humanos , Epidermodisplasia Verruciforme/diagnóstico , Infecciones por VIH/complicaciones , Imiquimod/uso terapéutico , Imiquimod/administración & dosificación , Infecciones por Papillomavirus/complicaciones , Infecciones por Papillomavirus/virología , Retinoides/uso terapéutico , Crioterapia , Proteínas de la Membrana
4.
BMC Health Serv Res ; 24(1): 792, 2024 Jul 09.
Artículo en Inglés | MEDLINE | ID: mdl-38982430

RESUMEN

BACKGROUND: Recently-updated global guidelines for cervical cancer screening incorporated new technologies-most significantly, the inclusion of HPV DNA detection as a primary screening test-but leave many implementation decisions at countries' discretion. We sought to develop recommendations for Malawi as a test case since it has the second-highest cervical cancer burden globally and high HIV prevalence. We incorporated updated epidemiologic data, the full range of ablation methods recommended, and a more nuanced representation of how HIV status intersects with cervical cancer risk and exposure to screening to model outcomes of different approaches to screening. METHODS: Using a Markov model, we estimate the relative health outcomes and costs of different approaches to cervical cancer screening among Malawian women. The model was parameterized using published data, and focused on comparing "triage" approaches-i.e., lesion treatment (cryotherapy or thermocoagulation) at differing frequencies and varying by HIV status. Health outcomes were quality-adjusted life years (QALYs) and deaths averted. The model was built using TreeAge Pro software. RESULTS: Thermocoagulation was more cost-effective than cryotherapy at all screening frequencies. Screening women once per decade would avert substantially more deaths than screening only once per lifetime, at relatively little additional cost. Moreover, at this frequency, it would be advisable to ensure that all women who screen positive receive treatment (rather than investing in further increases in screening frequency): for a similar gain in QALYs, it would cost more than four times as much to implement once-per-5 years screening with only 50% of women treated versus once-per-decade screening with 100% of women treated. Stratified screening schedules by HIV status was found to be an optimal approach. CONCLUSIONS: These results add new evidence about cost-effective approaches to cervical cancer screening in low-income countries. At relatively infrequent screening intervals, if resources are limited, it would be more cost-effective to invest in scaling up thermocoagulation for treatment before increasing the recommended screening frequency. In Malawi or countries in a similar stage of the HIV epidemic, a stratified approach that prioritizes more frequent screening for women living with HIV may be more cost-effective than population-wide recommendations that are HIV status neutral.


Asunto(s)
Análisis Costo-Beneficio , Detección Precoz del Cáncer , Cadenas de Markov , Años de Vida Ajustados por Calidad de Vida , Neoplasias del Cuello Uterino , Humanos , Femenino , Malaui/epidemiología , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/terapia , Neoplasias del Cuello Uterino/economía , Detección Precoz del Cáncer/economía , Detección Precoz del Cáncer/métodos , Adulto , Persona de Mediana Edad , Infecciones por VIH/diagnóstico , Infecciones por VIH/epidemiología , Crioterapia/economía , Tamizaje Masivo/economía , Tamizaje Masivo/métodos
5.
Support Care Cancer ; 32(7): 482, 2024 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-38955817

RESUMEN

PURPOSE: The study investigates cryotherapy's efficacy in mitigating Chemotherapy-induced peripheral neuropathy (CIPN), an adverse effect of chemotherapy that often leads to dosage reduction or treatment discontinuation. METHOD: The study was registered with PROSPERO (CRD42023428936). A literature search was conducted using the PubMed, Embase, and Cochrane Library databases. Randomized and nonrandomized controlled trials that investigated the effects of cryotherapy on CIPN were included for systematic review and meta-analysis. The primary outcome for prevention was the incidence of CIPN. RESULTS: We identified 17 trials involving 2,851 patients. In total, 11 trials compared the incidence of CIPN between cryotherapy and control groups. Significant differences in the incidence of CIPN at the midpoint and end of chemotherapy were observed, with risk ratios (RRs) of 0.23 (95% confidence interval [CI] = 0.13 to 0.43) and 0.54 (95% CI = 0.33 to 0.88), respectively. Cryotherapy also significantly reduced the incidence of sensory CIPN, with an RR of 0.67 (95% CI = 0.49 to 0.92). Additionally, cryotherapy demonstrated a significant reduction in the incidence of CIPN in patients with gynecological cancers (RR = 0.24, 95% CI = 0.14 to 0.41). Significantly favorable global quality of life scores following chemotherapy (standardized mean difference = 1.43; 95% CI = 0.50 to 2.36) and relieved neuropathic symptoms were found with cryotherapy. CONCLUSIONS: Cryotherapy demonstrates a pronounced preventive effect against the development of CIPN, providing substantial symptomatic relief and quality of life improvements for patients undergoing chemotherapy. The administration of cryotherapy through the use of frozen gloves and socks, or continuous-flow cooling systems, optimally initiated 15 min prior to and concluded 15 min following chemotherapy, is recommended for achieving maximum therapeutic efficacy.


Asunto(s)
Antineoplásicos , Crioterapia , Enfermedades del Sistema Nervioso Periférico , Humanos , Enfermedades del Sistema Nervioso Periférico/inducido químicamente , Enfermedades del Sistema Nervioso Periférico/prevención & control , Enfermedades del Sistema Nervioso Periférico/terapia , Crioterapia/métodos , Antineoplásicos/efectos adversos , Ensayos Clínicos Controlados Aleatorios como Asunto , Incidencia , Neoplasias/tratamiento farmacológico
7.
Sci Rep ; 14(1): 13890, 2024 06 17.
Artículo en Inglés | MEDLINE | ID: mdl-38880787

RESUMEN

Cryotherapy is widely utilized in medicine, particularly for pain management. This randomized clinical trial aimed to assess the effect of intraoral cold pack application (cryotherapy) on postoperative pain (POP) and the level of Substance P (SP) in patients with symptomatic apical periodontitis (SAP). Enrolled patients were randomly assigned to either cryotherapy or control group. After adequate anesthesia, access cavity, and biomechanical preparation of the root canal system were completed, the first apical fluid (AF) sample (S1) was obtained. A custom-made intraoral ice-gel pack was applied for 30 min in the cryotherapy group, while no intervention was performed in the control group. The second AF sample (S2) was collected 30 min later in both groups. Patients were asked to complete the Visual Analogue Scale (VAS) questionnaire to assess their POP. Quantification of SP in AF samples was performed using the enzyme-linked immunosorbent assay (ELISA) test. Data were analyzed statistically, revealing a significant reduction in POP and SP levels in the cryotherapy group compared to the control group (P ≤ 0.05). Furthermore, a moderate positive correlation was observed between SP levels and POP (P ≤ 0.05). In conclusion, intraoral cryotherapy represents a simple and cost-effective option for controlling POP and reducing inflammation levels in patients with SAP.


Asunto(s)
Crioterapia , Dolor Postoperatorio , Periodontitis Periapical , Sustancia P , Humanos , Sustancia P/metabolismo , Crioterapia/métodos , Femenino , Periodontitis Periapical/terapia , Periodontitis Periapical/cirugía , Masculino , Dolor Postoperatorio/terapia , Adulto , Persona de Mediana Edad , Dimensión del Dolor , Manejo del Dolor/métodos
8.
Lasers Surg Med ; 56(6): 541-550, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38922979

RESUMEN

OBJECTIVE: Our study aimed to evaluate the efficacy of this novel dermal cooling system (DCS) in reducing pigmentation in benign pigmented lesions in Asian patients and its potential side effects. METHODS: It was a prospective open-label single-center study. Asian patients, with the presence of benign pigmented lesions mainly including lentigines, melasma, nevus spilus, ephelides, café au lait, and seborrheic keratosis were recruited for a novel DCS. The DCS provided localized cooling of the epidermal layer below freezing but was less intense than cryotherapy. Each patient received DCS at Week 0 and repeated at 4-week intervals up to 10 sessions. Global aesthetic improvement scores (GAIS) by blinded physicians and subjects were recorded at 2, 6, and 12 months posttreatment follow-up. RESULTS: Eighty-one patients were recruited with a total of 305 sessions performed and 1716 lesion sites treated. At 2-month posttreatment, 76.5% and 58.6% treatment sites showed obvious to marked improvement respectively and the improvement sustained at 6 and 12 months. Only minor adverse events were reported. Erythema and edema were the most commonly anticipated effects immediately after treatment. The pain was minimal. Postinflammatory hyperpigmentation was only reported in 2.2% (38/1716) treated sites. CONCLUSION: To our knowledge, this study was the first study to demonstrate that this novel DCS was an effective, safe, and well-tolerated treatment for benign pigmented lesions in Asians.


Asunto(s)
Pueblo Asiatico , Trastornos de la Pigmentación , Humanos , Femenino , Masculino , Adulto , Estudios Prospectivos , Persona de Mediana Edad , Trastornos de la Pigmentación/terapia , Adulto Joven , Resultado del Tratamiento , Crioterapia/instrumentación , Crioterapia/métodos , Adolescente , Anciano , Estudios de Seguimiento
9.
Toxins (Basel) ; 16(6)2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38922167

RESUMEN

Envenomation by marine animals poses a significant health concern globally, affecting both local residents and tourists in coastal regions. The primary objective of this review is to critically evaluate the existing scientific literature to determine the most effective first-aid treatment for envenomations caused by marine animals, specifically whether hot-water immersion (HWI) or ice-pack treatment (IPT) provides the best immediate care. This comprehensive review covers a wide range of marine envenomations, from jellyfish stings to stingray injuries. While our focus is primarily on the efficacy of HWI and IPT, we also explore the role of cold-water treatment as a result of its relevance and similarity to ice-pack applications. In addition, we examine other treatments mentioned in the literature, such as medications or vinegar, and highlight their findings where applicable. To provide a clear and structured overview, we summarised the articles in separate tables. These tables categorise the type of research conducted, the marine species studied, the region of origin of the marine species, and the key findings of each study. Our analysis of the available evidence indicates a general consensus in the scientific community on the effectiveness of HWI or IPT for envenomation by marine animals. However, when treating those injuries, it is crucial to consider all factors since there is no universally superior treatment due to the diverse nature of marine habitats.


Asunto(s)
Mordeduras y Picaduras , Primeros Auxilios , Animales , Humanos , Primeros Auxilios/métodos , Mordeduras y Picaduras/terapia , Organismos Acuáticos , Calor , Inmersión , Crioterapia/métodos , Agua
10.
NeuroRehabilitation ; 54(4): 653-661, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38875049

RESUMEN

BACKGROUND: Spasticity is a common symptom of multiple sclerosis (MS), affecting 80% of patients. Many studies have aimed to detect methods to reduce spasticity under these conditions and found that spasticity can be efficiently reduced using cryotherapy. OBJECTIVE: To examine the impact of cryotherapy on spasticity among patients with MS. METHODS: Thirty-two participants were randomized into two groups. The study group was given airflow cryotherapy and a selected physical therapy program, whereas the control group was only given a selected physical therapy program. The treatment was administered three times each week for a total of twelve consecutive sessions. The outcome measures were the modified Ashworth scale and the H/M ratio. RESULTS: The study group showed significant decrease in calf muscle spasticity, indicated by a reduction in spasticity grade (p = 0.001) and a decrease in the H/M ratio of 33.81% (p = 0.001). The control group also showed significant reduction in calf muscle spasticity, as indicated by a reduction in spasticity grade (p = 0.001) and a reduction in the H/M ratio of 19.58% (p = 0.001). There was a significant decrease in the spasticity grade and H/M ratio of the study group posttreatment compared with those of the control group (p = 0.02 and p = 0.001). CONCLUSION: The combined effect of cryotherapy and a selected physical therapy program are more effective in controlling the spasticity of calf muscles in patients with MS than a selected physical therapy program alone.


Asunto(s)
Crioterapia , Esclerosis Múltiple , Espasticidad Muscular , Músculo Esquelético , Humanos , Espasticidad Muscular/etiología , Espasticidad Muscular/terapia , Espasticidad Muscular/rehabilitación , Crioterapia/métodos , Masculino , Femenino , Adulto , Esclerosis Múltiple/complicaciones , Persona de Mediana Edad , Músculo Esquelético/fisiopatología , Resultado del Tratamiento , Pierna/fisiopatología , Modalidades de Fisioterapia
11.
Trials ; 25(1): 404, 2024 Jun 21.
Artículo en Inglés | MEDLINE | ID: mdl-38907256

RESUMEN

BACKGROUND: Gout remains a leading cause of inflammatory arthritis worldwide, and the main risk factor for gout is persistent hyperuricemia. The clinical management of gout is mostly drug-based, and other treatment options are often ignored. This research proposal will explore whether exergames combined with ice therapy can help patients with gout to lose weight, relieve pain, improve the range of movement, improve quality of life, decrease uric acid level, decrease kinesiophobia and improve mental health of patients with gout. METHODS: This experiment will use a two-arm randomized controlled design. The study setting is at the Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM). Obese patients with gout (N = 30) will be randomly assigned to the control group (receive an exergames intervention) and intervention group (receive an exergames intervention combined with ice therapy). The outcomes measurement will be conducted before (baseline) and after intervention (4 weeks). Then, it will be followed up at 12 weeks. DISCUSSION: To our knowledge, no study has investigated the effect of exergames and ice therapy among gout patients. This study is expected to demonstrate that exercise rehabilitation facilitated by exergames with ice therapy is more effective in gout management compared to a conventional rehabilitation intervention. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2300070029). Registered on 31 March 2023.


Asunto(s)
Terapia por Ejercicio , Gota , Obesidad , Ensayos Clínicos Controlados Aleatorios como Asunto , Juegos de Video , Humanos , Gota/complicaciones , Gota/terapia , Terapia por Ejercicio/métodos , Obesidad/complicaciones , Obesidad/terapia , Obesidad/diagnóstico , Obesidad/fisiopatología , Resultado del Tratamiento , Calidad de Vida , Crioterapia/métodos , Malasia , Masculino , Persona de Mediana Edad , Terapia Combinada , Femenino , Adulto , Ácido Úrico/sangre , Pérdida de Peso
12.
Curr Opin Obstet Gynecol ; 36(4): 273-281, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38837702

RESUMEN

PURPOSE OF REVIEW: In this review article, we discuss myofascial-related chronic pelvic pain, pathophysiology, symptomology, and management options. RECENT FINDINGS: Despite high prevalence of myofascial pelvic pain, screening is not routinely performed by providers. Treatment modalities include pelvic floor physical therapy, pelvic floor trigger point injections with anesthetics or botulinum toxin A and cryotherapy. Other adjunct modalities, such as muscle relaxants and intravaginal benzodiazepines, are used, but data regarding their effectiveness is sparse. SUMMARY: Myofascial pelvic pain is an important, though overlooked component of chronic pelvic pain. Multimodal, multidisciplinary approach including patient education, pelvic floor physical therapy, and trigger point injections is the mainstay of the management of myofascial pelvic pain.


Asunto(s)
Dolor Crónico , Síndromes del Dolor Miofascial , Dolor Pélvico , Humanos , Dolor Pélvico/terapia , Dolor Pélvico/etiología , Femenino , Dolor Crónico/terapia , Síndromes del Dolor Miofascial/terapia , Diafragma Pélvico/fisiopatología , Modalidades de Fisioterapia , Toxinas Botulínicas Tipo A/uso terapéutico , Puntos Disparadores , Crioterapia/métodos
13.
Breast ; 76: 103763, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38941655

RESUMEN

OBJECTIVE: This study aimed to demonstrate the superiority of cryocompression over cryotherapy alone in the prevention of chemotherapy-induced peripheral neuropathy (CIPN) grade 2 or above. METHODS: This prospective randomized study was conducted between May 2020 and January 2023 in Innsbruck. Eligible patients had a diagnosis of gynecological cancer and received a minimum of 3 cycles of taxane-based CT (neoadjuvant, adjuvant or palliative therapy). Patients were randomized 1:1 to receive either cryotherapy or cryocompression on their upper extremities during chemotherapy (CT). We performed temperature measurements, two QoL questionnaires and neurological tests during CT and at follow-up 3 and 6-9 months after the completion of CT. CIPN was assessed using the CTCAE score. RESULTS: Of 200 patients recruited, both groups showed a lower prevalence of CIPN in this study compared to recent literature. In the group receiving cryotherapy, the prevalence of grade 1 CIPN was 30.1 %, and that of grade 2 CIPN or above was 13.7 %; in the group treated with cryocompression, the prevalence of grade 1 CIPN was 32.8 %, and that of grade 2 or above CIPN was 17.2 %. We found a significant reduction in temperature in the cryotherapy and cryocompression groups. Regarding the two QOL questionnaires as well as the neurological tests no significant differences were found between the two groups. CONCLUSION: Our study suggests that cryotherapy as well as cryocompression is a safe and effective way to cool patients' extremities to lower the prevalence of CIPN. Cryocompression was not more effective than cryotherapy alone in the prevention of CIPN.


Asunto(s)
Neoplasias de la Mama , Crioterapia , Neoplasias de los Genitales Femeninos , Enfermedades del Sistema Nervioso Periférico , Humanos , Femenino , Enfermedades del Sistema Nervioso Periférico/inducido químicamente , Enfermedades del Sistema Nervioso Periférico/prevención & control , Enfermedades del Sistema Nervioso Periférico/terapia , Estudios Prospectivos , Crioterapia/métodos , Persona de Mediana Edad , Neoplasias de los Genitales Femeninos/tratamiento farmacológico , Neoplasias de los Genitales Femeninos/terapia , Neoplasias de la Mama/tratamiento farmacológico , Anciano , Adulto , Calidad de Vida , Antineoplásicos/efectos adversos , Resultado del Tratamiento , Taxoides/efectos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Hidrocarburos Aromáticos con Puentes/efectos adversos , Hidrocarburos Aromáticos con Puentes/uso terapéutico
14.
Front Immunol ; 15: 1345046, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38827732

RESUMEN

Introduction: Recently, more and more research illustrated the importance of inducing CD4+ T helper type (Th)-1 dominant immunity for the success of tumor immunotherapy. Our prior studies revealed the crucial role of CD4+ Th1 cells in orchestrating systemic and durable antitumor immunity, which contributes to the satisfactory outcomes of the novel cryo-thermal therapy in the B16F10 tumor model. However, the mechanism for maintaining the cryo-thermal therapy-mediated durable CD4+ Th1-dominant response remains uncovered. Additionally, cryo-thermal-induced early-stage CD4+ Th1-dominant T cell response showed a correlation with the favorable prognosis in patients with colorectal cancer liver metastasis (CRCLM). We hypothesized that CD4+ Th1-dominant differentiation induced during the early stage post cryo-thermal therapy would affect the balance of CD4+ subsets at the late phase. Methods: To understand the role of interferon (IFN)-γ, the major effector of Th1 subsets, in maintaining long-term CD4+ Th1-prone polarization, B16F10 melanoma model was established in this study and a monoclonal antibody was used at the early stage post cryo-thermal therapy for interferon (IFN)-γ signaling blockade, and the influence on the phenotypic and functional change of immune cells was evaluated. Results: IFNγ at the early stage after cryo-thermal therapy maintained long-lasting CD4+ Th1-prone immunity by directly controlling Th17, Tfh, and Tregs polarization, leading to the hyperactivation of Myeloid-derived suppressor cells (MDSCs) represented by abundant interleukin (IL)-1ß generation, and thereby further amplifying Th1 response. Discussion: Our finding emphasized the key role of early-phase IFNγ abundance post cryo-thermal therapy, which could be a biomarker for better prognosis after cryo-thermal therapy.


Asunto(s)
Diferenciación Celular , Interferón gamma , Melanoma Experimental , Ratones Endogámicos C57BL , Células TH1 , Animales , Células TH1/inmunología , Ratones , Interferón gamma/metabolismo , Diferenciación Celular/inmunología , Melanoma Experimental/inmunología , Melanoma Experimental/terapia , Crioterapia/métodos , Línea Celular Tumoral , Femenino
15.
Support Care Cancer ; 32(6): 351, 2024 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-38748328

RESUMEN

Since the emergence of scalp cooling therapy (SCT) for the prevention of chemotherapy-induced alopecia (CIA), support groups on social media platforms for interested patients have surfaced. Though there are over 20,000 active members across SCT Facebook groups, little is known about how members use this platform. A 23-question survey was posted in five scalp cooling Facebook groups, reaching 219 women. Results indicated that these Facebook groups play clear roles in providing the following: (1) a supportive community for patients, (2) instructions for SCT use, (3) advice regarding insurance coverage and reimbursement, and (4) recommendations for over-the-counter products for hair loss. Despite reported interest in hair loss products, only 5% of patients sought medical treatment from dermatologists. Due to group-specific access restrictions, private Facebook groups provide patients with a protected platform to learn more about SCT from both those with personal experience and SCT company specialists. Providers may consider recommending these online groups to interested patients during the scalp cooling counseling process. As patients with CIA express a growing interest in over-the-counter hair, eyebrow, and eyelash products, it is important for dermatologists to be aware of where their patients obtain recommendations, and further, if these recommendations have clinical evidence of efficacy.


Asunto(s)
Alopecia , Cuero Cabelludo , Medios de Comunicación Sociales , Humanos , Alopecia/prevención & control , Alopecia/terapia , Femenino , Encuestas y Cuestionarios , Adulto , Persona de Mediana Edad , Grupos de Autoayuda , Antineoplásicos/efectos adversos , Antineoplásicos/administración & dosificación , Crioterapia/métodos , Anciano , Hipotermia Inducida/métodos
16.
J Drugs Dermatol ; 23(5): 327-331, 2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38709698

RESUMEN

Though it is widely acknowledged that cancer treatments cause hair loss on the scalp, there are limited data on how they affect eyebrow and eyelash hairs. Patients with eyebrow and eyelash loss, or madarosis, seek various treatment options ranging from camouflage techniques with makeup, permanent tattoos, and prescription medications. Though not yet studied in patients with cancer-induced madarosis, techniques such as scalp cooling, cryotherapy, and topical vasoconstrictors are promising preventative options. More robust research is needed to improve both the quality and quantity of available treatment and preventative options. There is a clear need for dermatologists to play a role in supportive oncodermatology for patients who experience eyebrow and eyelash loss secondary to chemotherapy, endocrine therapies, and radiation therapy. J Drugs Dermatol. 2024;23(5):327-331. doi:10.36849/JDD.8003.


Asunto(s)
Alopecia , Cejas , Pestañas , Humanos , Alopecia/etiología , Alopecia/terapia , Alopecia/diagnóstico , Neoplasias/terapia , Neoplasias/complicaciones , Antineoplásicos/efectos adversos , Antineoplásicos/administración & dosificación , Crioterapia/métodos
17.
J Appl Oral Sci ; 32: e20240017, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38775598

RESUMEN

OBJECTIVE: To compare the effect of submucosal cryotherapy using cold saline to dexamethasone sodium phosphate and diclofenac sodium injections on substance P and interleukin 6 release in experimentally induced pulpal inflammation in rabbits' molar teeth. METHODOLOGY: Fifteen rabbits were randomly classified into 3 groups according to the submucosal injection given: cold saline, dexamethasone sodium phosphate, and diclofenac sodium. A split-mouth design was adopted, the right mandibular molars were experimental, and the left molars served as the control without injections. Intentional pulp exposures were created and left for 6 hours to induce pulpitis. Pulpal tissue was extracted and examined for SP and IL-6 levels using ELISA. Within each group, the level of cytokines released was measured for both control and experimental groups for intragroup comparison to determine the effect of injection. The percentage reduction of each mediator was calculated compared with the control side for intergroup comparison then the correlation between SP and IL-6 levels was analyzed using Spearman's rank order correlation coefficient. Statistical analysis was performed, and the significance level was set at p<0.05. RESULTS: Submucosal cryotherapy, dexamethasone sodium phosphate, and diclofenac sodium significantly reduced SP and IL-6 pulpal release. Submucosal cryotherapy significantly reduced SP more than and IL-6 more than dexamethasone sodium phosphate and diclofenac sodium. Pulpal reduction of SP and IL-6 showed a strong positive significant correlation. CONCLUSIONS: Submucosal cryotherapy reduces the pulpal release of SP and IL-6 and could be tested as an alternative to premedication to potentiate the effect of anesthesia and control postoperative endodontic pain.


Asunto(s)
Antiinflamatorios no Esteroideos , Crioterapia , Pulpa Dental , Dexametasona , Diclofenaco , Ensayo de Inmunoadsorción Enzimática , Interleucina-6 , Pulpitis , Distribución Aleatoria , Sustancia P , Animales , Conejos , Pulpitis/terapia , Diclofenaco/farmacología , Dexametasona/farmacología , Dexametasona/análogos & derivados , Interleucina-6/análisis , Crioterapia/métodos , Sustancia P/análisis , Antiinflamatorios no Esteroideos/farmacología , Pulpa Dental/efectos de los fármacos , Factores de Tiempo , Reproducibilidad de los Resultados , Resultado del Tratamiento , Masculino , Estadísticas no Paramétricas , Modelos Animales de Enfermedad , Antiinflamatorios/farmacología , Solución Salina , Valores de Referencia
18.
Orthopadie (Heidelb) ; 53(6): 393-403, 2024 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-38787408

RESUMEN

BACKGROUND: Despite the high incidence of ankle sprains, the ideal treatment is controversial and a significant percentage of patients who have suffered an ankle sprain never fully recover. Even professional athletes are affected by this post-traumatic complication. There is strong evidence that permanent impairment after an ankle injury is often due to an inadequate rehabilitation and training program and too early return to sport. THERAPY AND REHABILITATION: Therefore, athletes should start a criteria-based rehabilitation after ankle sprain and gradually progress through the programmed activities, including e.g. cryotherapy, edema reduction, optimal load management, range of motion exercises to improve ankle dorsiflexion and digital guidance, stretching of the triceps surae with isometric exercises and strengthening of the peroneus muscles, balance and proprioception training, and bracing/taping. The fact that this is professional sport does not exempt it from consistent, stage-appropriate treatment and a cautious increase in load. However, there are a number of measures and tools that can be used in the intensive care of athletes to improve treatment and results.


Asunto(s)
Traumatismos del Tobillo , Humanos , Traumatismos del Tobillo/terapia , Traumatismos del Tobillo/rehabilitación , Traumatismos en Atletas/terapia , Traumatismos en Atletas/rehabilitación , Crioterapia/métodos , Terapia por Ejercicio/métodos , Fútbol , Esguinces y Distensiones/terapia , Esguinces y Distensiones/rehabilitación , Resultado del Tratamiento
19.
Curr Sports Med Rep ; 23(5): 171-173, 2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38709942

RESUMEN

ABSTRACT: A 23-year-old woman completing her first marathon collapsed near the finish line at 4 hours 6 min with a rectal temperature of 41.8°C. She was in good health before the race with no recent illness, had completed a full training program, and was taking no medications or supplements. On the initial exam, she was unconscious with a response to painful stimulus, spontaneous breathing, rapid pulse, eyes closed, fully dilated pupils, poor muscle tone, and pale skin that was warm to touch. The medical team initiated whole-body cooling using rapidly rotating ice water towels and ice packs placed in the neck, axilla, and groin. She developed echolalia during active cooling. About 20 minutes into the cooling procedure, she "woke up," was able to answer questions coherently, and her pupils were normal size and reactive. She was discharged home with instructions to follow-up in 2 d for evaluation and blood chemistry testing.


Asunto(s)
Golpe de Calor , Humanos , Femenino , Adulto Joven , Golpe de Calor/terapia , Golpe de Calor/diagnóstico , Hielo , Carrera de Maratón , Crioterapia/métodos , Esfuerzo Físico/fisiología
20.
Hemodial Int ; 28(3): 270-277, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38605472

RESUMEN

INTRODUCTION: In hemodialysis patients, pain associated with needle insertion into an arteriovenous fistula is a physical and psychological problem. The aim of this study was to assess the effectiveness of pre-puncture application of an ice pack, EMLA cream, or lidocaine spray to reduce pain associated with access puncture. METHODS: This was a multicenter study done in nine hemodialysis centers in Iraq. The study utilized a randomized, parallel-group design, in which patients being dialyzed using an arteriovenous access were allocated into one of four groups. Access puncture was preceded by nothing (control group), by use of ice pack cooling at the puncture site, by application of EMLA cream, or by application of lidocaine spray. Pain after access puncture was assessed during a single treatment for each patient. Pain was quantified using a Visual Analogue Scale. FINDINGS: A total of 1548 patients agreed to participate, and 1041 patients were included in the data analysis. Use of an ice pack, EMLA cream, or lidocaine spray each was associated with a lower pain score on access puncture compared with no pretreatment. The mean Visual Analogue Scores in the four groups were: 69.7 ± 15.7 in the controls, 39.8 ± 13.2 in the ice pack group, 45 ± 18.4 in the EMLA group, and 52.9 ± 15.2 in lidocaine group. Ranking of the pain severity scores suggested that ice pack use was associated with the least pain, followed by use of EMLA cream and use of lidocaine spray (severity score ranking, from lowest to highest, being 1.62, 2.18, and 2.63, respectively). DISCUSSION: Application of an ice pack prior to vascular access puncture is a fast and inexpensive technique to limit pain associated with this procedure.


Asunto(s)
Crioterapia , Combinación Lidocaína y Prilocaína , Dolor , Humanos , Masculino , Femenino , Persona de Mediana Edad , Dolor/etiología , Dolor/prevención & control , Crioterapia/métodos , Combinación Lidocaína y Prilocaína/administración & dosificación , Lidocaína/administración & dosificación , Lidocaína/uso terapéutico , Adulto , Anestésicos Locales/administración & dosificación , Manejo del Dolor/métodos , Punciones/métodos , Punciones/efectos adversos , Diálisis Renal/métodos , Diálisis Renal/efectos adversos , Prilocaína/administración & dosificación , Prilocaína/uso terapéutico
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...