Endometrial receptivity in cattle: the mutual reprogramming paradigm

Prior to implantation in cattle, the mucous medium contained in the uterine lumen serves as a working interface for molecular exchange and signaling between the lining endometrium and the embryo. The composition of this luminal fluid changes temporally according to the secretory and reabsorptive activities of the uterus and the embryo, which are under complex regulation. Via this interface, both the embryo and the endometrium reprogram each other's functions to support pregnancy continuation beyond the pre-implantation period. More specifically, the embryo receives elongation signals and the uterus receives anti-luteolytic stimuli. Here, characteristics of the luminal compartment as well as the regulation of its composition to determine the pregnancy outcome will be discussed.(AU)

[Participation of growth factors in human reproduction]. / Participación de los factores de crecimiento en la reproducción humana.

The Growth Factors (GFs) include a group peptidic molecules, with important trophic, mitotic and cellular differentiation effects in most human tissues. This review encompasses the different types of GFs and their biologic effects on tissues involved in the human reproductive process. The importance of the GF in the embryonic development and the implantation process is also commented. Finally, we assess the participation of the GFs in the pathophysiology of the Polycystic Ovary Syndrome and Endometriosis based on recent investigations. The review permit us appreciate the importance of the GFs as mediators of different hormones (in their secretion and biological effects) and in the regulation of some cellular events. The real value of these GFs in the daily clinical practice is as yet to be established, due to the technical laboratory limitations with respect to their identification and quantification, as well as the lack of more clinical research in humans. The GFs are promising molecules for the treatment of infertiles couples and for the application of the technics of assisted reproduction, in vivo and in vitro.

Mola hidatiforme / Hydatiforme mole

Se estudian 39 casos de embarazo molar atendidos en el Servicio de Ginecologia del Hospital de Clìnicas Universitario de La Paz entre los años 1986-90. La frecuencia de la mola es alta en este hospital y existe un aumento progresivo. Se observò en cualquier edad comprendida entre los 15 a 44 años. En el 11,9 porciento ocurre en adolescentes. La quinta parte de los pacientes son nuligestas y casi la cuarta parte son nuliparas. Las pacientes acuden a la consulta por la hemorragia que en muchos casos es profusa, pudiendo constituirse en causa de muerte. No en todo los casos existe la desproporciòn uterina-retraso mestrual. El tratamiento de rutina es la evaluaciòn por raspado uterino precidido o no de inducciòn. El seguimiento y control de las pacientes es deficiente