RESUMEN
A 26-year-old woman presented an eyelid lesion, after being scratched by a cat that had a similar skin lesion. It evolved into a cervical lymph node enlargement. With a hypothesis of Parinaud´s oculoglandular syndrome (POS) due to cat scratch disease (CSD), doxycycline was prescribed. After two weeks of treatment without improvement, a biopsy and blood sample were obtained. Itraconazole was prescribed and the skin lesion improved, but not the lymph node enlargement. A Sporothrix schenckii complex was isolated from the skin sample. Also, a specie-specific polymerase chain reaction detected Bartonella henselae DNA in her blood sample. Azithromycin was included to treat the bacterial infection, whereupon the lymph node also receded successfully. Sporotrichosis and CSD are zoonoses that can be transmitted to humans by traumatic inoculation due to scratches or bites from cats. Both can evolve with POS. Patients who present skin lesions and/or POS after being wounded by a cat should be investigated for both diseases.
Asunto(s)
Antibacterianos , Bartonella henselae , Enfermedad por Rasguño de Gato , Coinfección , Sporothrix , Esporotricosis , Femenino , Bartonella henselae/aislamiento & purificación , Bartonella henselae/genética , Humanos , Adulto , Sporothrix/aislamiento & purificación , Sporothrix/genética , Esporotricosis/microbiología , Esporotricosis/tratamiento farmacológico , Esporotricosis/diagnóstico , Coinfección/microbiología , Animales , Gatos , Antibacterianos/uso terapéutico , Enfermedad por Rasguño de Gato/microbiología , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Enfermedad por Rasguño de Gato/complicaciones , Enfermedad por Rasguño de Gato/diagnóstico , Azitromicina/uso terapéutico , Itraconazol/uso terapéutico , Doxiciclina/uso terapéutico , Piel/microbiología , Piel/patologíaRESUMEN
Cat scratch disease (CSD) is an infection caused by Bartonella henselae, presents with non-specific symptoms like lymphadenopathy, fever, and fatigue. It can progress to disseminated disease, leading to complications such as liver and splenic micro abscesses, osteomyelitis, encephalitis, and uveitis. Diagnosis is challenging due to varied presentations and limited tests. Treatment involves supportive care, with severe cases requiring antimicrobial therapy. In this report, we present a case of Cat scratch disease characterized by an atypical clinical manifestation, hepatosplenic and paravertebral involvement.
Asunto(s)
Bartonella henselae , Enfermedad por Rasguño de Gato , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Enfermedad por Rasguño de Gato/microbiología , Humanos , Bartonella henselae/aislamiento & purificación , Masculino , Antibacterianos/uso terapéutico , Femenino , AdultoRESUMEN
INTRODUCTION: The genus Bartonella includes species and subspecies of fastidious, facultative intracellular Gram-negative bacilli that infect a wide variety of mammalian reservoirs including cats and humans. In 2022, the Ecuadorian Ministry of Health reported an outbreak of cat scratch disease caused by B. henselae in the city of Guayaquil. Therefore, we aimed to characterize the presence of Bartonella spp. in domestic and stray cats from the area of Guayaquil where the outbreak happened in 2022. METHODS: Whole blood samples of 100 domestic and stray cats were collected. Riboflavin synthase (ribC) and 16S rRNA genes detection was performed by PCR using Bartonella spp. specific primers, followed by Sanger sequencing and phylogenetic analysis. RESULTS: 14 cats were positive for Bartonella spp. carriage. Phylogenetic analysis confirmed the presence of 12 cats infected with B. henselae and 2 cats with B. clarridgeiae. CONCLUSIONS: There is a high prevalence of Bartonella spp. carriage in cats in the city of Guayaquil within the area where a recent cat scratch disease outbreak happened. Considering the high presence of cats and other domestic and stray animals in the city of Guayaquil, a One Health approach for surveillance and prevention of zoonotic diseases like cat scratch disease is needed.
Asunto(s)
Infecciones por Bartonella , Bartonella henselae , Bartonella , Enfermedades de los Gatos , Enfermedad por Rasguño de Gato , Brotes de Enfermedades , Filogenia , ARN Ribosómico 16S , Animales , Gatos , Ecuador/epidemiología , Brotes de Enfermedades/veterinaria , Bartonella/genética , Bartonella/aislamiento & purificación , Bartonella/clasificación , Enfermedad por Rasguño de Gato/epidemiología , Enfermedad por Rasguño de Gato/microbiología , Enfermedades de los Gatos/microbiología , Enfermedades de los Gatos/epidemiología , Bartonella henselae/genética , Bartonella henselae/aislamiento & purificación , ARN Ribosómico 16S/genética , Infecciones por Bartonella/epidemiología , Infecciones por Bartonella/veterinaria , Infecciones por Bartonella/microbiología , Portador Sano/microbiología , Portador Sano/epidemiología , Portador Sano/veterinaria , Masculino , Femenino , PrevalenciaRESUMEN
Leprosy reactions are among the main causes of physical disability resulting from an infectious disease and can culminate in irreversible physical disabilities, therefore they should be considered a clinical emergency, as well as the elucidation of its cause. Co-infections are considered one of the main triggering causes of leprosy reactions, aggravating and maintaining these reactions for longer in these patients. After reporting a high rate of Bartonella henselae infection in patients with chronic type 2 leprosy reaction, 19/47 (40.4 %) compared to the control group, 9/50 (18.0 %), p = 0.0149, we conducted this study to observe the rate of infection by Bartonella sp. in a group of patients with chronic type 1 leprosy reactions. Blood samples from 14 patients with chronic type 1 leprosy reactions were analyzed by molecular and microbiological tests and compared. The results showed that, like patients with chronic type 2 leprosy reactions, this group of patients has a high proportion of B. henselae infection 6/14 (42.9 %), p = 0.88. We conclude that these bacteria can trigger chronic leprosy reactions and should be investigated in all chronic leprosy reactions patients. Summary Line: Our results showed that, like patients with chronic type 2 leprosy reactions, this group of patients has the same proportion of B. henselae DNA detection 6/14 (42.9 %), p = 0.88.
Asunto(s)
Bartonella henselae , ADN Bacteriano , Humanos , Bartonella henselae/genética , Bartonella henselae/aislamiento & purificación , ADN Bacteriano/análisis , Masculino , Femenino , Adulto , Persona de Mediana Edad , Estudios de Casos y Controles , Reacción en Cadena de la Polimerasa , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/microbiología , Coinfección/microbiología , Lepra/microbiología , Enfermedad Crónica , Adulto Joven , Factores de Tiempo , AncianoRESUMEN
Cat scratch disease (CSD) is caused by Bartonella henselae (B. henselae) and presents as lymphadenopathy following close contact with cats. However, in context of the global COVID-19 pandemic, clinical manifestations of CSD may vary, posing new challenges for healthcare professionals. Here we describe a case of a 54-year-old male with painful left upper arm mass, which gradually resolved until he was infected with COVID-19. The mass then rapidly progressed before admission. Meanwhile, pulmonary symptoms including pleural effusion emerged simultaneously. The cause was undetermined with routine blood culture and pathological test until the next generation sequencing (NGS) confirmed the presence of B. henselae. We believe this case is the first to report localized aggravation of CSD after COVID-19 infection and hopefully, offers treatment experience for clinicians worldwide.
Asunto(s)
Bartonella henselae , COVID-19 , Enfermedad por Rasguño de Gato , Humanos , Masculino , COVID-19/complicaciones , COVID-19/microbiología , Bartonella henselae/genética , Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/microbiología , Enfermedad por Rasguño de Gato/complicaciones , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Persona de Mediana Edad , Infección Latente , SARS-CoV-2RESUMEN
BACKGROUND: Cats are the primary reservoirs of the bacterium Bartonella henselae, the main cause of cat-scratch disease in humans. The main vector of the bacterium is the cat flea, Ctenocephalides felis. In southeastern Europe, data are lacking on the prevalence of B. henselae infection in cats, the strains of B. henselae involved and the risk factors associated with the infection. METHODS: Blood samples collected in ethylenediaminetetraacetic acid-containing tubes from 189 domestic cats (156 pet cats and 33 stray cats) from Zagreb, the capital city of Croatia, and 10 counties throughout Croatia were cultured for Bartonella spp. Following culture, bacterial isolates were genotyped at eight loci after using PCR to amplify 16S ribosomal RNA (rRNA) and the internal transcribed spacer region between the 16S and 23S rRNA sequences. Univariate and multivariate logistic regression were used to identify risk factors for B. henselae infection in cats. RESULTS: Bartonella spp. was detected in 31 cats (16.4%), and subsequent genotyping at the eight loci revealed B. henselae in all cases. Thirty complete multilocus sequence typing profiles were obtained, and the strains were identified as four sequence types that had been previously reported, namely ST5 (56.7%), ST6 (23.3%), ST1 (13.3%) and ST24 (3.3%), as well as a novel sequence type, ST33 (3.3%). The univariate analysis revealed a significantly higher risk of B. henselae infection in cats residing in coastal areas of Croatia (odds ratio [OR] 2.592, 95% confidence interval [CI] 1.150-5.838; P = 0.0191) and in cats with intestinal parasites (OR 3.207, 95% CI 1.088-9.457; P = 0.0279); a significantly lower risk was identified in cats aged > 1 year (OR 0.356, 95% CI 0.161-0.787; P = 0.0247) and in cats sampled between April and September (OR 0.325, 95% CI 0.147-0.715; P = 0.005). The multivariate analysis that controlled for age showed a positive association with the presence of intestinal parasites (OR 4.241, 95% CI 1.243-14.470; P = 0.0119) and coastal residence (OR 2.567, 95% CI 1.114-5.915; P = 0.0216) implying increased risk of infection, and a negative association with sampling between April and September (OR 0.379, 95% CI 0.169-0.848; P = 0.018) implying a decreased risk of infection. After controlling for the season, an increased risk of infection remained for the coastal region (OR 2.725, 95% CI 1.200-6.186; P = 0.012). CONCLUSIONS: Bartonella henselae is prevalent throughout Croatia and is a public health threat. Environmental and host factors can significantly affect the risk of infection, and these should be explored in more detail. The presence of intestinal parasites highlights the need to eliminate the flea vector, Ctenocephalides felis, as the most effective approach to control infections in cats and humans.
Asunto(s)
Infecciones por Bartonella , Bartonella henselae , Bartonella , Enfermedades de los Gatos , Enfermedad por Rasguño de Gato , Ctenocephalides , Animales , Gatos , Humanos , Enfermedad por Rasguño de Gato/epidemiología , Enfermedad por Rasguño de Gato/microbiología , Infecciones por Bartonella/epidemiología , Infecciones por Bartonella/veterinaria , Infecciones por Bartonella/microbiología , Croacia/epidemiología , Bartonella henselae/genética , Factores de Riesgo , Ctenocephalides/microbiología , Enfermedades de los Gatos/epidemiologíaRESUMEN
Leprosy reactions are an acute inflammatory phenomenon that can arise before diagnosis, during treatment, or after cure of leprosy. These reactions are considered one of the main diseases that cause physical disabilities. Immunosuppressive treatment for these immune responses makes these patients susceptible to coinfections, which can trigger new leprosy reactions. The main objective of this study was to evaluate the occurrence of infection by Bartonella sp. in blood samples from 47 patients who had untreatable episodes of type 2 leprosy reactions for more than six months, comparing them with a control group. Cultures and molecular methods (PCR) were used. Amplicons from species-specific reactions and sequencing showed a higher prevalence of Bartonella henselae infection in patients, 19/47 (40.4 %), compared to control, 9/50 (18.0 %), p = 0.0149. Five patients accepted treatment for coinfection, and all showed improvement in leprosy reactions with treatment for B. henselae infection. We conclude that these bacteria can trigger chronic reactions of type 2 leprosy and should be investigated in these patients. SUMMARY LINE: Patients who have chronic type 2 leprosy reactions are more susceptible to Bartonella henselae infection than controls: 19/47 (40.4 %) compared 9/50 (18.0 %), p = 0.0149.
Asunto(s)
Infecciones por Bartonella , Bartonella henselae , Bartonella , Enfermedad por Rasguño de Gato , Coinfección , Lepra , Humanos , Bartonella henselae/genética , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/microbiología , Bartonella/genética , Reacción en Cadena de la Polimerasa/métodos , Infecciones por Bartonella/diagnóstico , Infecciones por Bartonella/epidemiología , Infecciones por Bartonella/microbiologíaRESUMEN
This report describes the case of a 73-year-old female with a history of a prosthetic mitral valve and breast cancer who presented with fever and confusion. Brain imaging revealed multiple ischemic infarcts, and abdominal imaging demonstrated splenic infarcts. Workup with transesophageal echocardiogram revealed a vegetation on the aortic valve, but several blood cultures had no bacterial growth. Further history revealed a recent exposure to a stray cat, and the patient was found to have positive antibodies for Bartonella henselae, the organism implicated in cat scratch disease. She was treated with the appropriate course of antibiotics, and she made a full recovery to her baseline functional status. This report emphasizes the importance of a comprehensive patient history and a broad differential diagnosis.
Asunto(s)
Bartonella henselae , Enfermedad por Rasguño de Gato , Endocarditis Bacteriana , Endocarditis , Femenino , Humanos , Animales , Gatos , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Enfermedad por Rasguño de Gato/microbiología , Antibacterianos/uso terapéutico , Endocarditis Bacteriana/diagnóstico , Endocarditis Bacteriana/tratamiento farmacológico , Endocarditis Bacteriana/microbiología , Endocarditis/tratamiento farmacológicoRESUMEN
We report the case of a 6-year-old boy that presented with enlarged lymph nodes on his neck. He complained of tiredness and discouragement, which worsened during feverish periods. There were no relevant laboratory test abnormalities and serological tests were not reactive. Bartonella henselae DNA was detected by species-specific nested polymerase chain reaction. After treatment, the patient progressed with no fever or lymphadenopathy. Bartonellosis is a group of infectious diseases caused by bacteria of the genus Bartonella. This case report is a useful reminder to clinicians that long-term fever of unknown origin can be related to B. henselae infection, even if the specific serology is not reactive.
Asunto(s)
Infecciones por Bartonella , Bartonella henselae , Bartonella , Enfermedad por Rasguño de Gato , Linfadenopatía , Infecciones por Bartonella/diagnóstico , Bartonella henselae/genética , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/microbiología , Niño , Humanos , MasculinoRESUMEN
We studied retrospectively 651 PCR-confirmed Bartonella infections diagnosed at the French reference center for bartonellosis from 2014 to 2019. The most common form was cat-scratch disease (89%) followed by endocarditis (9%). Disseminated forms (2%) mainly presented as bacillary angiomatosis or peliosis hepatis in solid organ transplant recipients.
Asunto(s)
Bartonella henselae/fisiología , Enfermedad por Rasguño de Gato/microbiología , Adulto , Anciano , Bartonella henselae/genética , Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/inmunología , Femenino , Francia , Humanos , Huésped Inmunocomprometido , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Estudios Retrospectivos , Adulto JovenRESUMEN
Cat-scratch disease (CSD) is a systemic illness caused by the gram-negative bacteria Bartonella henselae (B. henselae). Cats serve as the primary host reservoir for B. henselae, with cat fleas as the horizontal vector of transmission. It is transmitted to humans through close contact with cats and cat scratches and bites. We describe two cases of bilateral Bartonella neuroretinitis that were presented to Palmerston North Hospital Eye Clinic.
Asunto(s)
Anticuerpos Antibacterianos/análisis , Bartonella henselae/inmunología , Ceguera/etiología , Enfermedad por Rasguño de Gato/complicaciones , Infecciones Bacterianas del Ojo/complicaciones , Agudeza Visual , Ceguera/diagnóstico , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/microbiología , Infecciones Bacterianas del Ojo/diagnóstico , Infecciones Bacterianas del Ojo/microbiología , Femenino , Angiografía con Fluoresceína , Fondo de Ojo , Humanos , Masculino , Adulto JovenRESUMEN
The genus Bartonella comprises emerging bacteria that affect humans and other mammals worldwide. Felids represent an important reservoir for several Bartonella species. Domestic cats are the main reservoir of Bartonella henselae, the agent of cat scratch disease (CSD). It can be transmitted directly by scratches and bites from infected cats and via cat fleas. This study aims to investigate the circulation of Bartonella spp. in free-ranging Neotropical wild felids from Southern Brazil using serological and molecular methods. In this study, 53 live-trapped free-ranging wild felids were sampled, 39 Leopardus geoffroyi and 14 Leopardus wiedii, from five municipalities in the Rio Grande, do Sul state, southern Brazil. All captured animals were clinically healthy. Two blood samples of L. geoffroyi were positive, by PCR, for the presence of B. henselae DNA. Conversely, none of L. wiedii blood samples were positive when tested using PCR. Indirect immunofluorescence assay (IFA) showed that 28% of serum samples of wild felids were reactive (seropositive) for B. henselae by immunofluorescence, with titers ranging from 64 to 256. The results presented here provide the first evidence of a Bartonella-enzootic cycle involving L. geoffroyi and L. wiedii, which may account for the spillover of the emerging zoonotic pathogen B. henselae for the indigenous fauna in Southern Brazil.
Asunto(s)
Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/veterinaria , Felidae/microbiología , Animales , Animales Salvajes , Anticuerpos Antibacterianos/sangre , Proteínas Bacterianas/genética , Bartonella/clasificación , Bartonella/genética , Bartonella/inmunología , Bartonella/aislamiento & purificación , Bartonella henselae/clasificación , Bartonella henselae/genética , Bartonella henselae/inmunología , Brasil , Enfermedad por Rasguño de Gato/microbiología , ADN Bacteriano/genética , Pradera , Nucleotidiltransferasas/genética , Fosfotransferasas (Aceptor de Grupo Alcohol)/genética , FilogeniaAsunto(s)
Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/complicaciones , Infecciones Bacterianas del Ojo/complicaciones , Mácula Lútea/patología , Degeneración Macular/etiología , Retinitis/complicaciones , Enfermedad Aguda , Enfermedad por Rasguño de Gato/diagnóstico , Enfermedad por Rasguño de Gato/microbiología , Infecciones Bacterianas del Ojo/diagnóstico , Infecciones Bacterianas del Ojo/microbiología , Humanos , Degeneración Macular/diagnóstico , Masculino , Retinitis/diagnóstico , Retinitis/microbiología , Tomografía de Coherencia Óptica/métodos , Adulto JovenRESUMEN
Bartonella henselae endocarditis mimicking systemic vasculitis has been reported in patients with valvulopathy. Herein, we describe a patient with B. henselae endocarditis involving a prosthetic pulmonic valve with positive anti-dsDNA antibodies misdiagnosed with systemic lupus erythematosus (SLE) based on the revised classification SLE criteria.
Asunto(s)
Anticuerpos Antinucleares/sangre , Bartonella henselae/crecimiento & desarrollo , Enfermedad por Rasguño de Gato/diagnóstico , Endocarditis Bacteriana/diagnóstico , Infecciones Relacionadas con Prótesis/diagnóstico , Animales , Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/microbiología , Gatos , Diagnóstico Diferencial , Endocarditis Bacteriana/microbiología , Reacciones Falso Positivas , Humanos , Lupus Eritematoso Sistémico , Masculino , Infecciones Relacionadas con Prótesis/microbiología , Estenosis de la Válvula Pulmonar/congénito , Estenosis de la Válvula Pulmonar/cirugía , Lobos , Adulto JovenRESUMEN
BACKGROUND: Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition, which is often triggered by certain types of infection, cancer and numerous autoimmune diseases; however, of the numerous infectious triggers associated with HLH, the consequences of Bartonella henselae infection have been rarely reported. CASE PRESENTATION: A 48-year-old female presented with a 20-day history of intermittent fever accompanied by systemic rash, fatigue, anorexia and weight loss later she developed shock and unconsciousness. Blood tests showed a reduction of leukocyte, anemia and thrombocytopenia, and pathological results of a bone marrow biopsy confirmed hemophagocytic activity. Metagenomic next-generation sequencing (mNGS) analysis of the lymph node detected the presence of B. henselae. Whole exome sequencing revealed two gene variants, STXBP2 and IRF5, in this adult patient with secondary HLH. Then, she received minocycline and rifampin combination anti-infective therapy. Intravenous immunoglobulin for 5 days followed by a high dose of methylprednisolone were also administered. The patient was successfully discharged from the intensive care unit and remained in good condition after 2 months of follow-up. CONCLUSIONS: mNGS served crucial roles in obtaining an etiological diagnosis, which suggested that screening for B. henselae should be considered in patients with HLH, especially those with a cat at home. In addition, the genetic defects were discovered to not only be present in primary HLH, but also in secondary HLH, even in the elderly.
Asunto(s)
Enfermedad por Rasguño de Gato/diagnóstico , Linfohistiocitosis Hemofagocítica/diagnóstico , Linfohistiocitosis Hemofagocítica/genética , Bartonella henselae/aislamiento & purificación , Enfermedad por Rasguño de Gato/microbiología , Femenino , Predisposición Genética a la Enfermedad , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Factores Reguladores del Interferón/genética , Ganglios Linfáticos/microbiología , Ganglios Linfáticos/patología , Linfohistiocitosis Hemofagocítica/microbiología , Persona de Mediana Edad , Técnicas de Diagnóstico Molecular , Proteínas Munc18/genéticaAsunto(s)
Anticuerpos Antibacterianos/inmunología , Antígenos Bacterianos/inmunología , Bartonella henselae/inmunología , Enfermedad por Rasguño de Gato/diagnóstico , Inmunoglobulina M/inmunología , Enfermedad por Rasguño de Gato/microbiología , Ensayo de Inmunoadsorción Enzimática , Humanos , Sarcosina/análogos & derivadosRESUMEN
Capnocytophaga canis is an uncommon cause of septic shock. Only three cases have been previously reported in the literature. In this article, we describe the case of a 70-year-old male admitted to the intensive care unit for septic shock of unknown origin. On day 2, one anaerobic bottle out of the two sets taken at admission turned positive with Gram-negative bacilli. The pathogen was identified by 16S rRNA gene as C. canis. The strain was characterized and compared with other clinical isolates of Capnocytophaga spp.
Asunto(s)
Capnocytophaga/aislamiento & purificación , Enfermedad por Rasguño de Gato/diagnóstico , Choque Séptico/diagnóstico , Anciano , Animales , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Capnocytophaga/genética , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Enfermedad por Rasguño de Gato/microbiología , Gatos , Diagnóstico Diferencial , Humanos , Masculino , Choque Séptico/tratamiento farmacológico , Choque Séptico/microbiologíaRESUMEN
El eritema nodoso es un tipo de reacción de hipersensibilidad tardía, que se manifiesta como nódulos eritematosos y dolorosos de predominio en miembros inferiores. Una de sus causas es la enfermedad por arañazo de gato producida por Bartonella henselae, aunque es poco habitual. Se expone un caso de eritema nodoso asociado a enfermedad por arañazo de gato diagnosticado en nuestro hospital, así como su manejo diagnóstico y terapéutico y su evolución
Erythema nodosum is a delayed-type hipersensitivity reaction that presents as erythematous and painful nodules on the shins. It can appear as an uncommon complication of cat scratch disease produced by Bartonella henselae. A rare case of erythema nodosum associated to cat scratch disease was diagnosed in our hospital. Its diagnostic, therapeutic management and evolution is reported. We have found in previous literature just a single case of association between erythema nodosum and cat scratch disease in a pediatric patient