RESUMEN
A 2-year-old female Greyhound was presented for inappetence and lethargy. On referral, results of diagnostic tests indicated renal glucosuria, increased excretion of selected amino acids and abnormal fractional excretion of electrolytes consistent with renal tubular dysfunction. Systemic blood pressure was elevated. Renal biopsy revealed mild proximal renal tubular damage consistent with a subacute toxic or hypoxic insult. Systemic hypertension, renal glucosuria and altered fractional excretion of electrolytes resolved during the 7 day period of hospital treatment. The Greyhound resumed training without recurrence of renal dysfunction.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Síndrome de Fanconi/veterinaria , Glucosuria Renal/veterinaria , Aminoácidos/orina , Animales , Diagnóstico Diferencial , Enfermedades de los Perros/terapia , Enfermedades de los Perros/orina , Perros , Electrólitos/orina , Síndrome de Fanconi/diagnóstico , Síndrome de Fanconi/terapia , Síndrome de Fanconi/orina , Femenino , Fluidoterapia/veterinaria , Glucosuria Renal/diagnóstico , Glucosuria Renal/terapia , Glucosuria Renal/orina , TerapéuticaRESUMEN
Massive immune hemolysis due to passenger lymphocyte-derived anti-D has not been reported in renal transplantation. A 50-year-old (B-positive) male received a dual deceased-donor kidney transplant (B-negative) for diabetic renal failure. Two weeks post-transplant, the patient developed severe hemolytic anemia. The donor anti-D titer was 1:8. The recipient anti-D titer (zero pre-transplant) increased from 1:4 to 1:16 over 4 days. Rapid hemolysis caused severe anemia, minimum Hb = 4.2 g/dL, while selectively lysing the patient's autologous red cells during this time. The hemolytic anemia did not impair the allografts and subsided without monoclonal B-cell pharmacotherapy or apheresis. The anti-D titer decreased to barely detectable levels at four months and had cleared when checked 2 years post-transplant. Transfusion support subsided after two months. If complications of anemia can be avoided, the deleterious effects of hemolysis may be well tolerated by renal allografts using antigen negative transfusion alone.