RESUMEN
Capillaria hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
Asunto(s)
Capillaria/fisiología , Infecciones por Enoplida , Hepatomegalia/parasitología , Estadios del Ciclo de Vida/fisiología , Hígado/parasitología , Enfermedades de los Roedores , Adulto , África , Animales , Antihelmínticos/administración & dosificación , Antihelmínticos/uso terapéutico , Anticuerpos Antihelmínticos/análisis , Anticuerpos Antihelmínticos/inmunología , Biopsia , Capillaria/efectos de los fármacos , Niño , Preescolar , Reservorios de Enfermedades , Infecciones por Enoplida/diagnóstico , Infecciones por Enoplida/epidemiología , Infecciones por Enoplida/inmunología , Infecciones por Enoplida/mortalidad , Infecciones por Enoplida/parasitología , Infecciones por Enoplida/patología , Infecciones por Enoplida/fisiopatología , Infecciones por Enoplida/terapia , Ensayo de Inmunoadsorción Enzimática , Europa (Continente) , Femenino , Hepatomegalia/inmunología , Hepatomegalia/patología , Hepatomegalia/fisiopatología , Humanos , Lactante , Estadios del Ciclo de Vida/efectos de los fármacos , Hígado/inmunología , Hígado/patología , Hígado/fisiopatología , Masculino , América del Norte , Filogeografía , Enfermedades de los Roedores/diagnóstico , Enfermedades de los Roedores/epidemiología , Enfermedades de los Roedores/inmunología , Enfermedades de los Roedores/mortalidad , Enfermedades de los Roedores/parasitología , Enfermedades de los Roedores/patología , Enfermedades de los Roedores/fisiopatología , Roedores , América del Sur , Tasa de Supervivencia , Tomografía Computarizada por Rayos XRESUMEN
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.
Asunto(s)
Animales , Masculino , Femenino , Ratas , Anticuerpos Antihelmínticos/sangre , Antígenos Helmínticos/administración & dosificación , Capillaria/inmunología , Infecciones por Enoplida/parasitología , Cirrosis Hepática Experimental/parasitología , Enfermedad Crónica , Modelos Animales de Enfermedad , Infecciones por Enoplida/tratamiento farmacológico , Infecciones por Enoplida/inmunología , Glucocorticoides/uso terapéutico , Hidroxiprolina/análisis , Cirrosis Hepática Experimental/tratamiento farmacológico , Cirrosis Hepática Experimental/inmunología , Prednisona/uso terapéutico , Ratas Wistar , Índice de Severidad de la EnfermedadRESUMEN
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.