RESUMEN
BACKGROUND: The appearance of diffuse lentigines in children is rare and a genetic syndrome should initially be envisaged. Another little-known cause of photo-distributed lentigines is use of voriconazole. We present a new case in which the original feature is the very short time of onset. PATIENTS AND METHODS: A 9-year-old immunosuppressed girl treated with voriconazole for 3 months presented lentigines in exposed areas after only 4 weeks of exposure. DISCUSSION: The literature contains only around ten cases of photo-distributed lentigines under voriconazole in children. The condition can appear very early, as in our case. Voriconazole also appears to induce cutaneous squamous cell carcinomas and even melanoma. The benefit-risk ratio of prescribing this drug must therefore be carefully evaluated, and close clinical monitoring and photoprotection must be instituted.
Asunto(s)
Erupciones por Medicamentos/etiología , Lentigo/inducido químicamente , Trastornos por Fotosensibilidad/complicaciones , Voriconazol/efectos adversos , Niño , Femenino , HumanosAsunto(s)
Citocinas/metabolismo , Fármacos Dermatológicos/efectos adversos , Lentigo/inducido químicamente , Metotrexato/efectos adversos , Psoriasis/tratamiento farmacológico , Adulto , Fármacos Dermatológicos/uso terapéutico , Humanos , Lentigo/patología , Masculino , Metotrexato/uso terapéutico , Piel/efectos de los fármacos , Piel/patologíaAsunto(s)
Lentigo/inducido químicamente , Inhibidores de Fosfodiesterasa/efectos adversos , Psoriasis/tratamiento farmacológico , Talidomida/análogos & derivados , Humanos , Lentigo/patología , Masculino , Persona de Mediana Edad , Inhibidores de Fosfodiesterasa/uso terapéutico , Psoriasis/complicaciones , Piel/patología , Talidomida/efectos adversos , Talidomida/uso terapéuticoRESUMEN
No disponible
Asunto(s)
Humanos , Masculino , Niño , Erupciones por Medicamentos/etiología , Inmunosupresores/efectos adversos , Lentigo/inducido químicamente , Tacrolimus/efectos adversos , Administración Tópica , Inmunosupresores/administración & dosificación , Tacrolimus/administración & dosificaciónAsunto(s)
Dermatosis Facial/inducido químicamente , Inmunosupresores/efectos adversos , Lentigo/inducido químicamente , Tacrolimus/efectos adversos , Niño , Dermatosis Facial/tratamiento farmacológico , Femenino , Humanos , Inmunosupresores/uso terapéutico , Boca , Tacrolimus/uso terapéutico , Vitíligo/tratamiento farmacológicoAsunto(s)
Antimetabolitos Antineoplásicos/efectos adversos , Erupciones por Medicamentos/etiología , Dermatosis del Pie/inducido químicamente , Dermatosis de la Mano/inducido químicamente , Lentigo/inducido químicamente , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Combinación de Medicamentos , Femenino , Dermatosis del Pie/patología , Dermatosis de la Mano/patología , Humanos , Masculino , Ácido Oxónico/efectos adversos , Piridinas/efectos adversos , Tegafur/efectos adversosRESUMEN
BACKGROUND: Skin ageing especially senile lentigo directly affects self-esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines. OBJECTIVE: To investigate the association between fine particulate matter (PM2.5 ) and skin ageing, particularly senile lentigo and seborrheic keratosis. METHODS: The study enrolled 400 Chinese women aged 40-90 years including 210 from the Yanqing county in Beijing (low PM2.5 exposure group) and 190 from the Xuanwumen in Beijing (high PM2.5 exposure group). Skin ageing symptoms, particularly senile lentigines and seborrheic keratoses, were clinically assessed using scores of intrinsic and extrinsic skin ageing. An ordinal logistic regression model was used to analyse the effect of PM2.5 on skin ageing adjusted for factors underlying skin ageing. RESULTS: In the study population of Xuanwumen, we found that senile lentigo on cheeks and back of hands was 1.48 times and 2.8 times higher, respectively, compared with those from Yanqing county. However, no association was found between PM2.5 and seborrheic keratosis. We found that other variables such as smoking, second-hand smoking, contact with fossil fuels and skin types were significantly associated with skin ageing. CONCLUSION: These results indicate that PM2.5 was another extrinsic factor promoting skin ageing.
Asunto(s)
Lentigo/inducido químicamente , Material Particulado , Adulto , Anciano , Anciano de 80 o más Años , Estudios Transversales , Femenino , Humanos , Lentigo/epidemiología , Persona de Mediana Edad , Envejecimiento de la PielAsunto(s)
Lentigo/inducido químicamente , Inhibidores de Fosfodiesterasa 4/efectos adversos , Psoriasis/tratamiento farmacológico , Talidomida/análogos & derivados , Adulto , Anciano , Ensayos Clínicos Fase III como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Talidomida/efectos adversosRESUMEN
The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. A total of 8 patients (2 males and 6 females) with ages that ranged from 34 to 62 years (mean: 48) presented an abrupt onset of a single facial brown-pink macule, generally asymmetrical, with an average size of 1.9 cm. after ingestion of a nonsteroidal antiinflammatory drugs that lasted for several months. Dermatoscopy mainly showed a pseudonetwork or uniform areas of brown pigmentation, brown or blue-gray dots, red dots and/or telangiectatic vessels. In the epidermis, histopathology showed a mild hydropic degeneration and focal melanin hyperpigmentation. Melanin can be found freely in the dermis or laden in macrophages along with a mild perivascular mononuclear infiltrate. The authors describe eruptive facial postinflammatory lentigo as a new variant of a fixed drug eruption on the face.
Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Dermoscopía , Erupciones por Medicamentos/patología , Dermatosis Facial/patología , Lentigo/patología , Piel/patología , Adulto , Biomarcadores/análisis , Biopsia , Chile , Erupciones por Medicamentos/etiología , Erupciones por Medicamentos/metabolismo , Dermatosis Facial/inducido químicamente , Dermatosis Facial/metabolismo , Femenino , Humanos , Hiperpigmentación/inducido químicamente , Hiperpigmentación/patología , Lentigo/inducido químicamente , Lentigo/metabolismo , Masculino , Melaninas/análisis , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Factores de Riesgo , Piel/química , Piel/efectos de los fármacos , EspañaAsunto(s)
Exposición a Riesgos Ambientales/efectos adversos , Dermatosis Facial/inducido químicamente , Dermatosis Facial/epidemiología , Lentigo/inducido químicamente , Emisiones de Vehículos/toxicidad , Anciano , Envejecimiento/fisiología , Contaminantes Atmosféricos/efectos adversos , Pueblo Asiatico/estadística & datos numéricos , Estudios de Cohortes , Exposición a Riesgos Ambientales/estadística & datos numéricos , Monitoreo del Ambiente , Dermatosis Facial/patología , Femenino , Humanos , Incidencia , Lentigo/patología , Masculino , Persona de Mediana Edad , Medición de Riesgo , Población Blanca/estadística & datos numéricosRESUMEN
Multiple lentiginosis are seen in many multisystemic diseases and during the course of many treatment schemes in the area of application of topical substances, PUVA, or more disseminated reactions in the case of systemic drugs. We report a case of a 67-year-old man with multiple comorbidities including vitiligo, and a recent diagnosis of inflammatory bowel disease, who developed millimeter-size, circular, brown macules in photoexposed areas both affected and not affected by vitiligo while was taken azathioprine, which disappeared after drug withdrawal. Biopsy showed groups of apoptotic keratinocytes, basal hyperpigmentation, and slight dermal inflammation. The authors describe "eruptive lentiginosis" as an adverse event of azathioprine not previously described in the literature.
Asunto(s)
Antiinflamatorios/efectos adversos , Azatioprina/efectos adversos , Erupciones por Medicamentos/etiología , Fármacos Gastrointestinales/efectos adversos , Enfermedades Inflamatorias del Intestino/tratamiento farmacológico , Lentigo/inducido químicamente , Piel/efectos de los fármacos , Vitíligo/complicaciones , Anciano , Apoptosis/efectos de los fármacos , Biopsia , Erupciones por Medicamentos/diagnóstico , Humanos , Enfermedades Inflamatorias del Intestino/complicaciones , Enfermedades Inflamatorias del Intestino/diagnóstico , Queratinocitos/efectos de los fármacos , Queratinocitos/patología , Lentigo/diagnóstico , Masculino , Piel/patología , Pigmentación de la Piel/efectos de los fármacos , Vitíligo/diagnósticoRESUMEN
Tyrosine kinase inhibitors (TKIs) are associated with various adverse cutaneous reactions, including pigmentary changes. Radotinib is a novel and selective BCR-ABL1 TKI, which has shown activity and safety in the treatment of patients with chronic myeloid leukaemia resistant or intolerant to imatinib. A 69-year-old Korean man presented with lentiginosis after taking radotinib for 6 months. On histopathological examination, the numbers of melanocytes and melanin pigment were found to be increased due to c-KIT activation, consequently upregulating microphthalmia-associated transcription factor. This finding is in contrast to previous reports analysing the mechanisms of previously reported tyrosine kinase inhibitors inhibiting c-KIT.
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Benzamidas/efectos adversos , Dermatosis Facial/inducido químicamente , Lentigo/inducido químicamente , Inhibidores de Proteínas Quinasas/efectos adversos , Pirazinas/efectos adversos , Anciano , Brazo , Humanos , MasculinoRESUMEN
Topical calcineurin inhibitors are widely used to treat inflammatory dermatoses for their steroid-sparing advantage. Herein, we report a patient with chronic lip dermatitis who developed multiple labial melanotic macules after application of tacrolimus 0.1% ointment and pimecrolimus 1% cream. Prior and current reports raise concerns for potential development of pigmented lesions associated with topical calcineurin inhibitor use. These reports highlight the need for careful risk-benefit assessment when prescribing topical calcineurin inhibitors for inflammatory dermatoses, especially when used on sun-exposed sites.
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Inhibidores de la Calcineurina/efectos adversos , Dermatitis Atópica/tratamiento farmacológico , Lentigo/inducido químicamente , Enfermedades de los Labios/inducido químicamente , Tacrolimus/análogos & derivados , Administración Cutánea , Adulto , Biopsia , Inhibidores de la Calcineurina/administración & dosificación , Diagnóstico Diferencial , Femenino , Humanos , Lentigo/patología , Enfermedades de los Labios/patología , Isomerasa de Peptidilprolil/antagonistas & inhibidores , Tacrolimus/administración & dosificación , Tacrolimus/efectos adversosAsunto(s)
Dermatomicosis/tratamiento farmacológico , Lentigo/inducido químicamente , Lentigo/patología , Pirimidinas/efectos adversos , Triazoles/efectos adversos , Corticoesteroides/efectos adversos , Corticoesteroides/uso terapéutico , Adulto , Negro o Afroamericano , Antifúngicos/efectos adversos , Antifúngicos/uso terapéutico , Dermatomicosis/diagnóstico , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Estudios de Seguimiento , Humanos , Masculino , Pirimidinas/uso terapéutico , Medición de Riesgo , Sarcoidosis Pulmonar/diagnóstico , Sarcoidosis Pulmonar/tratamiento farmacológico , Triazoles/uso terapéutico , Voriconazol , Población BlancaRESUMEN
Second primary melanomas (SPMs) induced by vemurafenib have been recently described. The aim of this study was to define the dermoscopical signs of melanoma in this context. Patients underwent a total body examination before receiving vemurafenib. Each single melanocytic lesion was registered before therapy by digital dermoscopy (DD), and then repeated monthly until therapy disruption. Forty-two patients were included, the mean duration of follow-up was 6.7 months, and a mean number of 51 lesions per patients were captured and followed. A total number of 2,155 lesions were recorded, of which 56.1% presented at least one change during the study. More common changes concerned the color of the lesions (up to 15%) and appearance or disappearance of globules (14.6%). Thirty-six of the melanocytic lesions were surgically excised, 21 were classified as a nevus, 1 was a lentigo, and 14 as a second new primary melanoma (occurring in 21% of our patients). DD allowed us to excise only 36/2,155 (1.6%) of the lesions and permitted us to detect 14 SPM in the 42 patients with a highly efficient malignant/benign ratio of 63.6%. Although vemurafenib is now tested in an adjuvant setting DD should be systematically used in order to accurately detect SPM and reduce the number of unnecessary excisions.
Asunto(s)
Indoles/efectos adversos , Melanoma , Neoplasias Primarias Secundarias/inducido químicamente , Neoplasias Primarias Secundarias/patología , Neoplasias Cutáneas , Sulfonamidas/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Dermoscopía , Inhibidores Enzimáticos/administración & dosificación , Inhibidores Enzimáticos/efectos adversos , Femenino , Estudios de Seguimiento , Humanos , Indoles/administración & dosificación , Lentigo/inducido químicamente , Lentigo/patología , Estudios Longitudinales , Masculino , Melanocitos/efectos de los fármacos , Melanocitos/patología , Melanoma/inducido químicamente , Melanoma/tratamiento farmacológico , Melanoma/patología , Persona de Mediana Edad , Nevo Pigmentado/inducido químicamente , Nevo Pigmentado/patología , Estudios Prospectivos , Neoplasias Cutáneas/inducido químicamente , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/patología , Pigmentación de la Piel/efectos de los fármacos , Sulfonamidas/administración & dosificación , VemurafenibRESUMEN
Sorafenib is a multikinase inhibitor FDA-approved for the treatment of advanced renal cell and hepatocellular carcinoma. Dermatologic side effects include hand-foot skin reaction, facial and scalp erythema and desquamation, splinter subungual hemorrhages, alopecia, pruritus, xerosis, keratoacanthomas, and squamous cell carcinomas. We report sudden eruption of melanocytic nevi diffusely in a patient receiving sorafenib.