1.
Biomed Chromatogr
; 26(2): 142-6, 2012 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21538417
RESUMEN
High-performance liquid chromatographic methods were developed for separation of the enantiomers of mirtazapine and its four process-related substances. The direct separations were achieved on chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H), cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-H) and cellulose tris(4-methylbenzoate) (Chiralcel OJ-H ). The experimental data were utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on retention and separation. The elution sequence was determined under the optimized separation conditions.
Asunto(s)
Amilosa/análogos & derivados , Celulosa/análogos & derivados , Cromatografía Líquida de Alta Presión/instrumentación , Mianserina/análogos & derivados , Fenilcarbamatos/química , Amilosa/química , Celulosa/química , Cromatografía Líquida de Alta Presión/métodos , Mianserina/química , Mianserina/normas , Mirtazapina , Estereoisomerismo
2.
Lancet
; 335(8685): 343-4, 1990 Feb 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-1967780
3.
Arch Gen Psychiatry
; 45(2): 193-4, 1988 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-3122701