RESUMEN
Simultaneous occurrence of granuloma annulare and necrobiosis lipoidica is quite rare. There are seven reported cases in the literature, but only one presenting ulcerated necrobiosis lipoidica. We report a 39-year-old male with histopathologically confirmed granuloma annulare and ulcerated necrobiosis lipoidica, without diabetes mellitus.
Asunto(s)
Granuloma Anular/complicaciones , Necrobiosis Lipoidea/complicaciones , Adulto , Granuloma Anular/patología , Humanos , Masculino , Necrobiosis Lipoidea/patologíaRESUMEN
Ocorrência simultânea de granuloma anular e necrobiose lipoídica é rara. Sete casos dessa associação foram encontrados na literatura, sendo somente um de necrobiose lipoídica ulcerada. Relata-se caso de concomitância de granuloma anular e necrobiose lipoídica ulcerada, não associada a diabetes mellitus, em paciente masculino de 39 anos, com confirmação histopatológica.
Simultaneous occurrence of granuloma annulare and necrobiosis lipoidica is quite rare. There are seven reported cases in the literature, but only one presenting ulcerated necrobiosis lipoidica. We report a 39-year-old male with histopathologically confirmed granuloma annulare and ulcerated necrobiosis lipoidica, without diabetes mellitus.
Asunto(s)
Adulto , Humanos , Masculino , Granuloma Anular/complicaciones , Necrobiosis Lipoidea/complicaciones , Granuloma Anular/patología , Necrobiosis Lipoidea/patologíaRESUMEN
BACKGROUND: Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin. METHODS: A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia. RESULTS: Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission. CONCLUSION: This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.
Asunto(s)
Antiinflamatorios/uso terapéutico , Histiocitosis/tratamiento farmacológico , Melfalán/uso terapéutico , Necrobiosis Lipoidea/tratamiento farmacológico , Paraproteinemias/tratamiento farmacológico , Prednisona/uso terapéutico , Adulto , Diagnóstico Diferencial , Quimioterapia Combinada , Femenino , Histiocitosis/complicaciones , Histiocitosis/diagnóstico , Humanos , Necrobiosis Lipoidea/complicaciones , Necrobiosis Lipoidea/diagnóstico , Paraproteinemias/complicaciones , Paraproteinemias/diagnósticoRESUMEN
Com base em uma revisäo crítica de literatura pertinente, säo feitas consideraçöes sobre a "necrobiosis lipoidica diabeticorum", incluindo a etiopatogenia, quadro clínico epidemiologia e o tratamento. De modo especial é abordada a associaçäo com o diabetes. Säo analisados os dados de 24 pacientes, sendo três pessoais e os demais obtidos através de questionário enviado a dermatologistas de diferentes regiöes do país
Asunto(s)
Adulto , Persona de Mediana Edad , Humanos , Masculino , Femenino , Diabetes Mellitus/etiología , Necrobiosis Lipoidea/complicaciones , Corticoesteroides/uso terapéutico , Diabetes Mellitus/diagnóstico , Fibrinolíticos/uso terapéutico , Técnica del Anticuerpo Fluorescente , Necrobiosis Lipoidea/cirugía , Necrobiosis Lipoidea/tratamiento farmacológico , Tibia/lesionesRESUMEN
A 48-year-old woman with generalized scleroderma of the acrosclerosis type developed several lesions clinically, histologically and ultrastructurally, which were characteristic of necrobiosis lipoidica. The lesions were located to scar tissue. An increased collagen synthesis is suggested as a possible explanation.