RESUMEN
BACKGROUND: Documentation of lingual tumors is scarce in nonhuman primates. METHODS: Through a multi-institutional retrospective study we compile cases of primary and metastatic neoplasia in non-human primates. RESULTS: We describe five cases of lingual neoplasia. Three cases are primary lingual tumors: chondro-osteoblastic lipoma in a howler monkey, squamous cell carcinoma, and fibroma in two baboons. We describe two cases of metastatic lymphoma in the tongue in rhesus macaques. A literature review of published lingual neoplasia in nonhuman primates is included in this manuscript. CONCLUSION: Lingual neoplasia is seldom reported in non-human primates.
Asunto(s)
Enfermedades de los Monos , Papio , Neoplasias de la Lengua , Animales , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Masculino , Femenino , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/veterinaria , Neoplasias de la Lengua/diagnóstico , Estudios Retrospectivos , Macaca mulatta , Carcinoma de Células Escamosas/veterinaria , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/diagnóstico , Lipoma/veterinaria , Lipoma/patología , Lipoma/diagnósticoRESUMEN
An artificial intelligence (AI) model was designed to assist pathologists in diagnosing and quantifying structural changes in tongue lesions induced by chemical carcinogens. Using a tongue cancer model induced by 4-nitroquinoline-N-oxide and treated with ß-elemene, a total of 183 digital pathology slides were processed. The Segment Anything Model (SAM) was employed for initial segmentation, followed by conventional algorithms for more detailed segmentation. The epithelial contour area was computed using OpenCV's findcontour method, and the skeletonize method was used to calculate the distance map and skeletonized representation. The AI model demonstrated high accuracy in measuring tongue epithelial thickness and the number of papilla-like protrusions. Results indicated that the model group had significantly higher epithelial thickness and fewer papillae compared with the blank group. Furthermore, the treatment group exhibited reduced epithelial thickness and fewer papilla-like protrusions compared with the model group, though these differences were less pronounced. Overall, the SAM framework algorithm proved effective in quantifying tongue epithelial thickness and the number of papilla-like protrusions, thereby assisting healthcare professionals in understanding pathological changes and assessing treatment outcomes.
Asunto(s)
Algoritmos , Sesquiterpenos , Neoplasias de la Lengua , Lengua , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/inducido químicamente , Neoplasias de la Lengua/veterinaria , Neoplasias de la Lengua/tratamiento farmacológico , Sesquiterpenos/uso terapéutico , Animales , Lengua/patología , Lengua/efectos de los fármacos , 4-Nitroquinolina-1-Óxido , Inteligencia Artificial , Carcinógenos/toxicidad , Masculino , RatasRESUMEN
A 10 year-old endurance Arabian mare was presented with an invasive, firm, multilobulated mass at the left ventral face of the tongue. The mare had a history of four months of ptyalism, dysphagia, severe halitosis, and dysmastication. The Evaluation of the horse included physical and oral examination, complete blood count and serum biochemistry profile, computed tomography evaluation of the head, and histopathology of the mass. The computerized tomography (CT) head scan showed the homogeneous mass in the oral cavity confirming the degree of invasion on the tongue, as well as a small mineral focus at the left dorsal mandibular border and increased density of the submandibular lymph nodes. At necropsy, gross findings in the oral cavity revealed an irregular, nodular and partially ulcerated mass at the level of the body of the tongue in the ventral aspect, with a size of approximately 10 × 15 × 8 cm. Histologically, the tongue revealed a neoplastic process of mesenchymal muscle origin. The tumor cells showed distinctive morphological and architectural patterns in some areas. An immunohistochemistry panel was done yielding a positive reaction for Calponin and Desmin, confirming diagnostics of as a soft tissue leiomyosarcoma in the tongue. Immunohistochemistry results, in combination with histopathologic morphology, were suggestive of a leiomyosarcoma originating in the perivascular wall tissue. Oral leiomyosarcoma are very rare in veterinary medicine, and to the authors' knowledge, this is the first case report to utilize histopathology, immunohistochemistry and imaginology to describe oral leiomyosarcoma in a horse.
Asunto(s)
Enfermedades de los Caballos , Leiomiosarcoma , Neoplasias de la Lengua , Animales , Femenino , Enfermedades de los Caballos/diagnóstico , Caballos , Inmunohistoquímica , Leiomiosarcoma/diagnóstico , Leiomiosarcoma/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Lengua/diagnóstico por imagen , Neoplasias de la Lengua/diagnóstico , Neoplasias de la Lengua/veterinariaRESUMEN
Chondrosarcomas are common tumors of the canine appendicular and axial skeleton; however, extraskeletal chondrosarcomas are very rare. Herein we report a case of extraskeletal chondrosarcoma in the tongue of a dog. Histologically, glossal skeletal muscle was infiltrated and effaced by islands of cartilage and streams of spindle-shaped cells. Retrospective analysis of 236 tongue masses submitted to the Iowa State University surgical biopsy service between 2011 and 2019 showed that the majority of submitted tongue masses are either non-neoplastic or benign, with granular cell tumors identified as the most prevalent benign neoplasms. Malignant tumors accounted for nearly 30% of all submitted masses, with malignant melanoma diagnosed most frequently.
Asunto(s)
Condrosarcoma/veterinaria , Enfermedades de los Perros/patología , Neoplasias de los Tejidos Conjuntivo y Blando/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Condrosarcoma/patología , Perros , Masculino , Neoplasias de los Tejidos Conjuntivo y Blando/patología , Estudios Retrospectivos , Neoplasias de la Lengua/patologíaRESUMEN
The biological behaviour of the tumours vary according to the species in which they occur, its location within the cavity, clinical stage and histopathological nature. Lingual neoplasms are generally uncommon in companion animals. Rhabdomyosarcomas are malignant, solid, aggressive formations with high metastatic potential. The clinical signs are variable and a definitive diagnosis can only be reached through histopathological analysis of biopsy and necropsy specimen. In some cases, immunohistochemical study may be needed to confirm the diagnosis. This paper aims to highlight important points about this uncommon condition in dogs, using a case report of lingual rhabdomyosarcoma, which showed no evidence of metastasis after diagnosis, nor of local recurrence after surgical excision with a wide safety margin. It was concluded that early diagnosis, the correct interpretation of the complementary tests and the appropriate therapeutic approach contributed to improving the quality of life and survival of the patient in question.(AU)
O comportamento biológico dos tumores varia de acordo com a espécie animal, a localização na cavidade, a fase clínica e a natureza histopatológica. As neoplasias orais são geralmente incomuns em animais de companhia. Os rabdomiossarcomas são formações malignas, sólidas e agressivas, com alto potencial metastático. Os sinais clínicos são variáveis e o diagnóstico definitivo só pode ser alcançado por meio da análise histopatológica do material colhido. Em alguns casos, o estudo imuno-histoquímico pode ser necessário para confirmar o diagnóstico. Este trabalho tem como objetivo destacar pontos importantes sobre essa condição incomum em cães, utilizando um relato de caso de rabdomiossarcoma lingual, no qual não se evidenciaram metástases após o diagnóstico, nem recorrência local após a excisão cirúrgica com ampla margem de segurança. Concluiu-se que o diagnóstico precoce, a correta interpretação dos exames complementares e a abordagem terapêutica adequada contribuíram para melhorar a qualidade de vida e a sobrevida do paciente em questão.(AU)
Asunto(s)
Animales , Perros , Rabdomiosarcoma/patología , Rabdomiosarcoma/terapia , Rabdomiosarcoma/veterinaria , Neoplasias de la Lengua/veterinariaRESUMEN
Squamous cell carcinoma (SCC) is one of the most common malignant neoplasms in horses, but lingual SCC has seldom been reported. On separate occasions, a 12-year-old American Quarter Horse mare and an 18-year-old American Saddlebred stallion were presented to the Auburn University Large Animal Teaching Hospital for evaluation of weight loss, dysphagia, and ptyalism. Evaluation of each horse included physical examination, skull radiographs, oral examination, complete blood count and serum biochemistry profile, endoscopic evaluation of the mouth, and biopsy of tissue from a lesion found on the tongue. Histopathologic assessment of tissue harvested from the lingual lesions led to a diagnosis of SCC in each case. The diagnosis prompted euthanasia for one horse, but radiation therapy appeared to delay the progression of the lesion in the other horse.
Asunto(s)
Carcinoma de Células Escamosas/veterinaria , Neoplasias de Cabeza y Cuello/veterinaria , Enfermedades de los Caballos , Carcinoma de Células Escamosas de Cabeza y Cuello/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Carcinoma de Células Escamosas/patología , Femenino , Neoplasias de Cabeza y Cuello/patología , Enfermedades de los Caballos/patología , Caballos , Masculino , Carcinoma de Células Escamosas de Cabeza y Cuello/patología , Neoplasias de la Lengua/patología , Estados UnidosRESUMEN
A mass was found at the base of the dorsum linguae of a male 11-year-old Labrador retriever. The tumor comprised of ganglion cells and Schwannian cells with Verocay bodies. The ganglion cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and beta III tubulin. The Schwannian cells were positive for neuron-specific enolase, S-100, nerve growth factor receptor, and glial fibrillary acidic protein. The lingual mass was diagnosed as a ganglioneuroma. To our knowledge, there has been no previous report of a lingual ganglioneuroma in a dog.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Ganglioneuroma/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Enfermedades de los Perros/patología , Perros , Ganglioneuroma/diagnóstico , Ganglioneuroma/patología , Masculino , Lengua/patología , Neoplasias de la Lengua/diagnóstico , Neoplasias de la Lengua/patologíaRESUMEN
Canine T-zone lymphoma (TZL) is a subtype of T-cell lymphoma characterized by unique histologic pattern and cytomorphology, immunophenotypic loss of CD45 expression, and an indolent clinical behaviour. Dogs with TZL typically present with 1 or more enlarged lymph nodes and/or lymphocytosis. We describe a novel extranodal presentation of TZL involving the tongue. Twelve dogs with tongue masses were diagnosed with lingual TZL based on a variable combination of immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry and/or PCR for antigen receptor rearrangement (PARR) assay. Eleven dogs exhibited concurrent lymphocytosis and/or lymph node enlargement. Three cases were initially diagnosed as plasma cell tumours based on histology alone, thereby revealing a potential diagnostic challenge. Seven dogs achieved clinical remission and 4 achieved stable disease following variable treatment, consistent with the indolent nature of typical TZL involving the lymph nodes and peripheral blood. In 1 case the TZL resulted in progressive disease and failure to respond to treatment. In this case, the TZL exhibited histologic features of a higher grade neoplasm. This case series highlights a unique presentation of TZL and identifies a new differential diagnosis for lingual neoplasia. In this study, we characterize the clinical presentation, diagnostic features and patient outcomes of 12 dogs with lingual TZL.
Asunto(s)
Enfermedades de los Perros/patología , Linfoma de Células T/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Enfermedades de los Perros/diagnóstico , Perros , Femenino , Linfoma de Células T/diagnóstico , Linfoma de Células T/patología , Masculino , Lengua/patología , Neoplasias de la Lengua/diagnóstico , Neoplasias de la Lengua/patologíaRESUMEN
A 48-yr-old captive white rhinoceros ( Ceratotherium simum ) was euthanized due to old age, pododermatitis, and progressive laminitis of the middle toe of the left fore- and hindlimbs. Severe chronic necrotizing periodontitis and dental loss was diagnosed, although food intake prior to death had not decreased. In addition, extensive ulceration of the tongue was noted. Histologically, squamous cell carcinoma of the tongue was diagnosed with chronic severe ulcerative glossitis. Metastatic lesions were not detected. Clinicians should monitor the oral health of aging rhinoceros due to the occult nature of these lesions.
Asunto(s)
Carcinoma de Células Escamosas/veterinaria , Perisodáctilos , Neoplasias de la Lengua/veterinaria , Animales , Animales de Zoológico , Carcinoma de Células Escamosas/patología , Femenino , Neoplasias de la Lengua/patologíaRESUMEN
Acute inflammatory response after photodynamic therapy is frequently described, and increase on mast cell degranulation is also present during this process. The mast cell activation may improve angiogenesis, and this fact has been associated with progression of oral premalignant lesions (OPL). The aim of this study was to evaluate whether photodynamic therapy (PDT) increases mast cell density (MCD) and microvessels density (MVD) in 4-nitroquinoline-1-oxide(4NQO)-induced OPL in rats. 4NQO-induced OPL were treated or not with 5-ALA followed by laser irradiation (PDT group and 4NQO groups, respectively). Mast cells and CD34+ microvessels were counted. Both PDT and 4NQO groups had MCD and MVD that were higher than normal mucosa (p b 0.05). The 4NQO group had the lowest number of non-degranulated MCD in comparison to experimental periods of PDT (PDT 6 h p=0.020; 24 h p=0.016; 48 h p=0.003; 72 h p=0.033). Only in the PDT group did MCD and MVD have a significant correlation (r= 0.6219, p = 0.010). 5-ALA-mediated PDT modified the MCD and MVD in the induced OPL, leading to degranulation of mast cells and angiogenesis. A PDT protocol with an efficient eradication of the OPL must be adopted considering the angiogenesis potential associated with the mast cell activation after the therapy.
Asunto(s)
Ácido Aminolevulínico/uso terapéutico , Mastocitos/fisiología , Microvasos/patología , Fármacos Fotosensibilizantes/uso terapéutico , Neoplasias de la Lengua/tratamiento farmacológico , 4-Nitroquinolina-1-Óxido/toxicidad , Ácido Aminolevulínico/farmacología , Animales , Antígenos CD34/metabolismo , Degranulación de la Célula/efectos de los fármacos , Degranulación de la Célula/efectos de la radiación , Femenino , Hiperplasia/inducido químicamente , Hiperplasia/patología , Rayos Láser , Mastocitos/citología , Mucosa Bucal/efectos de los fármacos , Mucosa Bucal/patología , Neovascularización Fisiológica/efectos de los fármacos , Neovascularización Fisiológica/efectos de la radiación , Fotoquimioterapia , Fármacos Fotosensibilizantes/farmacología , Ratas , Ratas Wistar , Lengua/patología , Neoplasias de la Lengua/inducido químicamente , Neoplasias de la Lengua/veterinariaRESUMEN
Granular cell tumors (GCTs) are histologically characterized by polygonal neoplastic cells with abundant eosinophilic cytoplasmic granules. In humans, these cells are considered to be derived from Schwann cells, and the cytoplasmic granules are assumed to be autophagosomes or autophagolysosomes. However, the origin and nature of the cytoplasmic granules in canine GCTs have not been well characterized. The present study examined 9 canine lingual GCTs using immunohistochemistry, transmission electron microscopy (TEM), and cell culture and xenotransplantation experiments. In some cases, the tumor cells expressed S100, CD133, and desmin. The cytoplasmic granules were positive for LC3, p62, NBR1, and ubiquitin. TEM revealed autophagosome-like structures in the cytoplasm of the granule-containing cells. The cultured GCT cells were round to spindle shaped and expressed S100, nestin, Melan-A, CD133, LC3, p62, NBR1, and ubiquitin, suggesting that they were of neural crest origin, redifferentiated into melanocytes, and exhibited upregulated autophagy. The xenotransplanted tumors consisted of spindle to polygonal cells. Only a few cells contained cytoplasmic granules, and some had melanin pigments in their cytoplasm. The xenotransplanted cells expressed S100, nestin, Melan-A, and CD133. P62 and ubiquitin were detected, regardless of the presence or absence of cytoplasmic granules, while LC3 and NBR1 were detected only in the neoplastic cells containing cytoplasmic granules. These findings suggest that some xenotransplanted cells redifferentiated into melanocytes and that autophagy was upregulated in the cytoplasmic granule-containing cells. In conclusion, canine lingual GCTs originate from the neural crest and develop cytoplasmic granules via autophagy. In addition, the microenvironment of GCT cells affects their morphology.
Asunto(s)
Autofagia/fisiología , Gránulos Citoplasmáticos/ultraestructura , Enfermedades de los Perros/patología , Tumor de Células Granulares/patología , Neoplasias de la Lengua/veterinaria , Animales , Perros , Femenino , Tumor de Células Granulares/ultraestructura , Masculino , Ratones SCID , Microscopía Electrónica de Transmisión/veterinaria , Trasplante de Neoplasias , Lengua/patología , Lengua/ultraestructura , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/ultraestructura , Células Tumorales CultivadasRESUMEN
Different types of papillomavirus usually cause papillomas in specific tissues. Previously, bovine papillomavirus (BPV) type 10 has been associated specifically with cutaneous papillomas in cattle. In this study, BPV-10 was detected in a papilloma on the tongue of a cow. Whole genome analysis demonstrated that the sequence of this BPV-10 strain had a 129 base pair deletion in the E1 open reading frame, which was confirmed by Southern blot analysis, PCR and reverse transcriptase-PCR.
Asunto(s)
Enfermedades de los Bovinos/virología , Deltapapillomavirus/genética , Deltapapillomavirus/aislamiento & purificación , Papiloma/veterinaria , Infecciones por Papillomavirus/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Bovinos , Eliminación de Gen , Papiloma/virología , Neoplasias de la Lengua/virologíaRESUMEN
With the exception of solar-induced dermal hemangiosarcoma (HSA), the biologic behaviour of canine HSA is characterised by rapid tumour growth, a high metastatic rate and short survival times. Outcome of dogs with HSA of the tongue has not been previously reported. The purpose of this study was to assess outcome and prognostic factors in dogs with lingual HSA. Clinical data was collected retrospectively and histopathology was reviewed for 20 dogs. Median progression free survival was 524 days and the median overall survival time was 553 days. All dogs had low or intermediate grade tumours; most tumours were small and located on the ventral surface of the tongue. Prognostic factors significantly associated with increased survival included small tumour size and absence of clinical signs of an oral mass at the time of diagnosis. Dogs with HSA confined to the tongue may have a better prognosis compared with HSA in other organs.
Asunto(s)
Enfermedades de los Perros/cirugía , Hemangiosarcoma/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Antineoplásicos/uso terapéutico , Quimioterapia Adyuvante , Enfermedades de los Perros/tratamiento farmacológico , Enfermedades de los Perros/patología , Perros , Femenino , Hemangiosarcoma/tratamiento farmacológico , Hemangiosarcoma/patología , Hemangiosarcoma/cirugía , Masculino , Metástasis de la Neoplasia , Recurrencia Local de Neoplasia , Pronóstico , Estudios Retrospectivos , Neoplasias de la Lengua/tratamiento farmacológico , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/cirugía , Resultado del TratamientoRESUMEN
A 15-year-old female beagle dog was presented for a lingual liposarcoma. Full staging of the disease did not show any evidence of metastasis. A tongue rotation for reconstruction after rostral hemiglossectomy was performed after removal of the mass. This surgical technique may be useful in tongue reconstruction after trauma or tumor excision.
Rotation de la langue pour une reconstruction après une hémiglossectomie rostrale pour l'excision d'un liposarcome du quadrant rostral de la langue d'un chien. Une chienne Beagle âgée de 15 ans a été présentée pour un liposarcome lingual. La pleine stadification de la maladie n'a pas montré de preuves de métastase. Une rotation de la langue pour la reconstruction subséquente à une hémiglossectomie rostrale a été réalisée après l'enlèvement de la masse. Cette technique chirurgicale peut être utile dans la reconstruction de la langue après un traumatisme ou l'excision d'une tumeur.(Traduit par Isabelle Vallières).
Asunto(s)
Enfermedades de los Perros/cirugía , Liposarcoma/veterinaria , Procedimientos de Cirugía Plástica/veterinaria , Neoplasias de la Lengua/veterinaria , Lengua/cirugía , Animales , Perros , Femenino , Liposarcoma/cirugía , Lengua/patología , Neoplasias de la Lengua/cirugíaRESUMEN
OBJECTIVE: To describe the clinical characteristics, treatments, outcomes, and factors associated with survival time in a cohort of dogs with lingual neoplasia that underwent surgical excision. DESIGN: Retrospective case series. Animals-97 client-owned dogs. PROCEDURES: Medical records of dogs with a lingual tumor examined between 1995 and 2008 were reviewed. Records were included if a lingual tumor was confirmed by histologic examination and surgical excision of the mass was attempted. Data were recorded and analyzed to identify prognostic factors. RESULTS: Clinical signs were mostly related to the oral cavity. For 93 dogs, marginal excision, subtotal glossectomy, and near-total glossectomy were performed in 35 (38%), 55 (59%), and 3 (3%), respectively. Surgery-related complications were rare, but 27 (28%) dogs had tumor recurrence. The most common histopathologic diagnoses for the 97 dogs were squamous cell carcinoma (31 [32%]) and malignant melanoma (29 [30%]). Eighteen (19%) dogs developed metastatic disease, and the overall median survival time was 483 days. Median survival time was 216 days for dogs with squamous cell carcinoma and 241 days for dogs with malignant melanoma. Dogs with lingual tumors ≥ 2 cm in diameter at diagnosis had a significantly shorter survival time than did dogs with tumors < 2 cm. CONCLUSIONS AND CLINICAL RELEVANCE: Similar to previous studies, results indicated that lingual tumors are most commonly malignant, and squamous cell carcinoma and malignant melanoma predominate. A thorough physical examination to identify lingual tumors at an early stage and surgical treatment after tumor identification are recommended because tumor size significantly affected survival time.
Asunto(s)
Enfermedades de los Perros/cirugía , Neoplasias de la Lengua/veterinaria , Animales , Carcinoma de Células Escamosas/cirugía , Carcinoma de Células Escamosas/veterinaria , Perros , Femenino , Hemangioma/cirugía , Hemangioma/veterinaria , Linfoma/cirugía , Linfoma/veterinaria , Masculino , Mastocitoma/cirugía , Mastocitoma/veterinaria , Melanoma/cirugía , Melanoma/veterinaria , Mioepitelioma/cirugía , Mioepitelioma/veterinaria , Neoplasias de la Vaina del Nervio/cirugía , Neoplasias de la Vaina del Nervio/veterinaria , Plasmacitoma/cirugía , Plasmacitoma/veterinaria , Estudios Retrospectivos , Sarcoma/clasificación , Sarcoma/cirugía , Sarcoma/veterinaria , Análisis de Supervivencia , Neoplasias de la Lengua/cirugíaRESUMEN
An 11-year-old male Belgian shepherd dog was evaluated for a one-week history of progressive lethargy, decreased appetite and excessive panting. On physical examination, a pedunculated mass protruding from the right side of the tongue base was observed. The mass was solid, irregular and multi-lobulated, and it measured approximately 4 × 2 cm. The mass was surgically excised. The histological examination was consistent with a lingual osteoma and the margins were free of neoplastic cells. The dog was euthanased eight months after the diagnosis because of an unrelated problem and no evidence of recurrence at the surgical site was appreciated at that time. To the author's knowledge, this is the first report of a lingual osteoma in a dog, and, therefore, it should be included in the differential diagnosis of masses on the tongue, especially pedunculated masses located at the base of the tongue.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Osteoma/veterinaria , Neoplasias de la Lengua/veterinaria , Animales , Enfermedades de los Perros/cirugía , Perros , Masculino , Osteoma/diagnóstico , Osteoma/cirugía , Neoplasias de la Lengua/diagnóstico , Neoplasias de la Lengua/cirugía , Resultado del TratamientoRESUMEN
The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the study of squamous cell carcinoma of the oral cavity (CCEC). The clear advantage is that the model is very similar to the physiological process of malignancy. The model has clear benefits by and is suitable for applications in therapeutic research.
La carcinogénesis oral experimental inducida por el químico 4-nitroquinolina 1-óxido (4NQO) es uno de los métodos más frecuentes en el estudio del carcinoma de células escamosas de la cavidad oral (CCECO). La clara ventaja del modelo radica en el gran parecido al proceso fisiológico de la neoplasia maligna. El modelo tiene beneficios claros y es adecuado para las aplicaciones de la investigación terapéutica.
Asunto(s)
Animales , Ratas , Carcinoma de Células Escamosas/etiología , Neoplasias de la Lengua/inducido químicamente , Neoplasias de la Lengua/ultraestructura , Neoplasias de la Lengua/veterinaria , Neoplasias/inducido químicamente , Neoplasias/ultraestructura , Neoplasias de la Boca/inducido químicamente , Neoplasias de la Boca/ultraestructura , Neoplasias de la Boca/veterinaria , Ratas/anatomía & histología , Ratas/lesionesRESUMEN
Bovine papillomavirus type 12 (BPV-12, putative type BAA1) was detected in epithelial papilloma located on the tongue of an infected cow. Then, the whole genome was sequenced, and phylogenetic analysis illustrated that it should be classified as a member of the genus Xipapillomavirus. The viral genome is 7197 base pairs in length and contains five early ORFs (E1, E2, E4, E7 and E8), three late ORFs (L1, L2 and L3), and a long control region that possesses replication regulatory elements. Meanwhile, mRNA of each gene was detected in the papilloma sample. The papilloma was identified as epithelial papilloma by histological and immunohistochemical examination. Based on the genome information and pathological properties, BAA1 was designated as BPV-12 in this study.
Asunto(s)
Enfermedades de los Bovinos/virología , Papiloma/veterinaria , Infecciones por Papillomavirus/veterinaria , Neoplasias de la Lengua/veterinaria , Xipapillomavirus/aislamiento & purificación , Animales , Secuencia de Bases , Bovinos , Enfermedades de los Bovinos/patología , Genoma Viral , Datos de Secuencia Molecular , Sistemas de Lectura Abierta , Papiloma/patología , Papiloma/virología , Infecciones por Papillomavirus/patología , Infecciones por Papillomavirus/virología , Filogenia , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/virología , Xipapillomavirus/clasificación , Xipapillomavirus/genéticaRESUMEN
A 12-year-old, 25 kg, intact male St Bernard crossbreed was presented for treatment of a 538 mm ulcerated tumour on the dorsal tongue. Fine-needle aspiration cytology revealed a plasmacytoma. The dog staged negative for evidence of local metastatic or systemic disease. Histopathology confirmed the diagnosis. Treatment with one 150 Gy dose of radiation delivered with strontium-90 plesiotherapy was performed. Side effects were not noted and there was no visible evidence of tumour remaining at 2 months and 1 year after therapy.