Chemical constituents, biological activity and therapeutic uses, of Scutia buxifolia Reissek

Scutia buxifolia has been used in the treatment of a number of diseases, which includes bacterial and fungal infections, hypertension, Alzheimer's Disease and cancer. S. buxifolia contains biologically active compounds such as flavonoids, steroids, tanins, lipids, terpens and alkaloids. A range of biological activities has been found from plant extract and fractions, including antioxidant, acetylcholinesterase inhibitor, antiviral and antibiotic. Some studies about the potential toxicity were performed; however the results are not conclusive, suggesting that a single administration of the extract is safe, whereas prolonged use has deleterious effects for the body. The revised databases were SciELO, PubMed, ScienceDirect and Portal da Capes considering studies between 1964 and 2014 and by searching for terms like Scutia buxifolia, Rhamnaceae family, Scutia buxifolia Constituents, Scutia buxifolia use and OECD(AU)

Scutia buxifolia se utiliza en el tratamiento de una serie de enfermedades que incluye infecciones bacterianas y fúngicas, hipertensión, enfermedad de Alzheimer y cáncer. S. buxifolia contiene compuestos biológicamente activos tales como flavonoides, taninos, esteroides, lípidos, terpenos y alcaloides. A partir del extracto y las fracciones de la planta surgen una gama de actividades biológicas, que incluyen antioxidante, inhibidor de la acetilcolinesterasa, antiviral y antibiótico. Se realizaron algunos estudios sobre el potencial tóxico, sin embargo los resultados no son concluyentes, lo que sugiere que una sola administración del extracto es segura, mientras que el uso prolongado tiene efectos perjudiciales para el organismo. Las bases de datos revisadas fueron SciELO, PubMed, ScienceDirect y Portal de Capes, teniendo en cuenta los estudios entre 1964 y 2014 y mediante la búsqueda de términos como Scutia buxifolia, Rhamnaceae family, Scutia buxifolia constituents, Scutia buxifolia uses and OECD(AU)

Regulation of nodulation in the absence of N2 is different in actinorhizal plants with different infection pathways.

Root nodulation in actinorhizal plants, like Discaria trinervis and Alnus incana, is subject to feedback regulatory mechanisms that control infection by Frankia and nodule development. Nodule pattern in the root system is controlled by an autoregulatory process that is induced soon after inoculation with Frankia. The final number of nodules, as well as nodule biomass in relation to plant biomass, are both modulated by a second mechanism which seems to be related to the N status of the plant. Mature nodules are, in part, involved in the latter process, since nodule excision from the root system releases the inhibition of infection and nodule development. To study the effect of N(2) fixation in this process, nodulated D. trinervis and A. incana plants were incubated under a N(2)-free atmosphere. Discaria trinervis is an intercellularly infected species while A. incana is infected intracellularly, via root hairs. Both symbioses responded with an increment in nodule biomass, but with different strategies. Discaria trinervis increased the biomass of existing nodules without significant development of new nodules, while in A. incana nodule biomass increased due to the development of nodules from new infections, but also from the release of arrested infections. It appears that in D. trinervis nodules there is an additional source for inhibition of new infections and nodule development that is independent of N(2) fixation and nitrogen assimilation. It is proposed here that the intercellular Frankia filaments commonly present in the D. trinervis nodule apex, is the origin for the autoregulatory signals that sustain the blockage of initiated nodule primordia and prevent new roots from infections. When turning to A. incana plants, it seems likely that this signal is related to the early autoregulation of nodulation in A. incana seedlings and is no longer present in mature nodules. Thus, actinorhizal symbioses belonging to relatively distant phylogenetic groups and displaying different infection pathways, show different feedback regulatory processes that control root nodulation by Frankia.