Asunto(s)
Antineoplásicos/uso terapéutico , Autoanticuerpos/sangre , Cetuximab/uso terapéutico , Desensibilización Inmunológica/métodos , Inmunoglobulina E/sangre , alfa-Galactosidasa/inmunología , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/inmunología , Carcinoma de Células Escamosas/secundario , Esquema de Medicación , Humanos , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/inmunología , Neoplasias Pulmonares/secundario , Masculino , Persona de Mediana Edad , Neoplasias Faríngeas/tratamiento farmacológico , Neoplasias Faríngeas/inmunología , Neoplasias Faríngeas/patología , Seno Piriforme/efectos de los fármacos , Seno Piriforme/inmunología , Seno Piriforme/patología , Pruebas Cutáneas , alfa-Galactosidasa/sangreRESUMEN
BACKGROUND/AIMS: Larynx preservation for laryngopharyngeal carcinomas aims to avoid the mutilation of a total laryngectomy without compromising survival or functionality. The aim of the present study on pyriform sinus squamous cell carcinoma (SCC) is to evaluate the long-term functional outcomes of larynx preservation in good responders to induction chemotherapy (ICT). METHODS: The study was carried out in a tertiary referral cancer center in France. The subjects were good responders to ICT for pyriform sinus SCC, subsequently treated with adjuvant radiation therapy (RT) - with or without concomitant chemotherapy - between 1999 and 2008. Only patients without recurrence at 3 years were included. The evaluated pharyngolaryngeal functions were airway patency, oral communication and oral feeding, based on a self-administered questionnaire and the patients' medical records. RESULTS: Twenty-eight patients were retained. Two (7%) patients needed a tracheotomy during or after the treatment and 2 (7%) had total laryngectomy for a late local recurrence. At least 3 years after the end of treatment, all patients were exclusively fed by mouth. All the evaluated patients judged their voice performance as 'adequate for everyday oral communication'. CONCLUSIONS: In the long run, patients with pyriform sinus SCC who are candidates for larynx preservation and respond favorably to ICT present a satisfactory functional outcome when treated with adjuvant RT.