Local administration of 2% trimecaine affects the content of fucosylated glycoconjugates in goblet cells in rabbit tracheal epithelium.

The proportion of fucosylated glycoconjugate-containing rabbit tracheal goblet cells after intratracheal application of trimecaine was studied to evaluate its possible unfavourable effects. This lapine model is comparable with diagnostic findings in humans because airway epithelia in humans and rabbits are similar; tracheal epithelium is also practically identical to bronchial epithelium in both species. Local trimecaine anaesthesia caused a proportional decrease in percentage of the tracheal goblet cells containing both alpha(1-2)- and alpha(1-6)-, alpha(1-3)- and alpha(1-4)-fucosylated glycoconjugates as revealed 10 min postexposure using lectin histochemistry. In previous studies, only mild ultrastructural damage to the airway's epithelium was revealed, but a conspicuous decrease in sialylated glycoconjugate-containing tracheal goblet cells and the dominance of acidic sulphated glycoconjugates were observed as after-effects of the same treatment. Glycoconjugate changes can influence the inner environment of airways (e.g. viscoelastic properties of the airways' mucus and mucosal barrier functions) and thus the patient's defence barriers in airways may be weakened. Concurrently, the histochemical properties of goblet cells can be altered in bronchoscopic specimens. Since trimecaine is widely used as local anaesthesia in airways in bronchoscopy, it is necessary to heed these aforementioned effects.

[Effect of trimecaine derivatives and lidocaine on hemodynamics]. / Vliianie proizvodnykh trimekaina i lidokaina na gemodinamiku.

The results of experiments on cats showed that quaternidine, a quaternary ammonium derivative of trimecaine, does not induce significant variations in the hemodynamic parameters, being advantageous in this respect to some well-known antiarrhythmic drugs. LKhT-3-00 (dialkylaminophenylacetamide glutaminate)--a tertiary derivative of lidocaine--leads to a slight decrease in the heart rate, an insignificant decrease in the arterial pressure for 10 min, and a pronounced enhancement of the pumping ability of the left ventricle over a time period of 30 min.

[Peridural anesthesia with morphine and trimecaine: an analysis of 2000 cases]. / Peridural'naia anesteziia morfinom i trimekainom: analiz 2000 nabliudenii.

Complex investigations of 2000 patients have shown that peridural anesthesia represents an adequate anesthesiologic defense of the patient from the operative stress. The potentiating effect of morphine is greater with greater doses and results in systemic elevation of sensory thresholds, suppression of the emotional component of perception of pain and a prolongation of anesthesia. A conclusion is made that in some patients operations on lower extremities and small pelvis organs should be performed under peridural anesthesia in combination with subnarcotic doses of sedative drugs.

[Epiduro-sacral anesthesia in proctology]. / Epidural'no-sakral'naia anesteziia v proktologii.

The experience with 1023 epidural-sacral anesthesias for hemorrhoids, paraproctites, chronic anal fissures, anal papillomas has shown the method to be effective, technically simple, safe and parsimonious. The epidural-sacral anesthesia can be widely used in small proctology.

[Prolonged peridural block for postoperative analgesia in heart surgery patients]. / Dlitel'naia peridural'naia blokada dlia posleoperatsionnogo obezbolivaniia u kardiokhirurgicheskikh bol'nykh.

Prolonged peridural blockade with trimekain used in 1000 cardiosurgical patients is shown to be an effective prophylactic measure against postoperative complications. This method should not be widely used in patients with blood circulation insufficiency.

[Complications in peridural anesthesia]. / Oslozhneniia pri peridural'noi anestezii.

An analysis of complications associated with peridural anesthesia (PA) in 1000 women operated upon in the clinic of gynecology and obstetrics was carried out. In time of operation the number of complications constituted 5%; 0,5% of them were dangerous to life (collapse--0.4%, cardiac arrest--0.1%). Neither fatality nor disability resulting from PA were noted. The frequency rate of complications associated with PA does not exceed that one following other methods of anesthesia. The authors believe it possible to use PA in hypovolemic conditions after their preliminary correction or parallel to it.

[Complications of peridural anesthesia]. / Oslozhneniia peridural'noi anestezii

Peridural anesthesia is believed to be a complicated kind of analgesia yielding grave complications (syncope, apnoe, collapse, persistant and pronounced hypotension, nematomyelia, paraplegia of the lower extremities, Brown--Seguard syndrome and many others). This king od anesthesia is permissible only in an anesthesiological or reanimatological department. The frequency of complications depends on a level of injecting the anesthetic, patient's status and age. The former is the greater the higher the level of the peridural space puncture. To combat against complications occurring while using this kind of analgesia everything necessary for reanimation provision (intubation of the trachea, closed and open heart massage, etc.) should be ready at hand.