Tuberculosis ósea en calcáneo. Caso clínico / Bone tuberculosis in calcaneus. Clinical case

La tuberculosis extra pulmonar osteoarticular es una entidad infrecuente (16%), y aquellas de compromiso extravertebral son a su vez muy infrecuentes. Presentamos el caso clínico de un paciente masculino de 68 años de edad, con hipertensión arterial sistémica y enfermedad renal crónica, que presenta aproximadamente 1 año de evolución tórpida con dolor en retropié izquierdo, empeorando luego de infiltración con esteroide, con aumento de volumen, limitación funcional, y lesión ulcerosa con exudado purulento en cara medial. Siendo evaluado de forma clínica y con estudios de imagen por diferentes facultativos, hasta realizar toma de biopsia y cultivo óseo con diagnóstico de Tuberculosis ósea en calcáneo izquierdo. Tratado de manera quirúrgica, y actualmente cumpliendo tratamiento antituberculoso, con evolución satisfactoria recuperando movilidad articular, sin dolor y disminución del volumen de retropié(AU)

Osteoarticular extrapulmonary tuberculosis is a rare entity (16%), and those with extravertebral involvement are in turn very rare. We present the clinical case of a 68-years-old male patient with systemic arterial hypertension and chronic kidney disease, who presents approximately 1 year of torpid evolution with pain in the left hindfoot, worsening after steroid infiltration, with increased volume, limitation functional, and ulcerative lesion with purulent exudate on the medial side. He was being evaluated clinically and with imaging studies by different doctors, until taking a biopsy and bone culture with a diagnosis of Bone Tuberculosis in the left calcaneus. Surgically treated, and currently undergoing antituberculous treatment, with satisfactory evolution recovering joint mobility, without pain and decrease in rearfoot volume(AU)

Examining variation in skeletal tuberculosis in a late pre-contact population from the eastern mountains of Peru.

OBJECTIVE AND MATERIALS: This research evaluates the presence and chronology of tuberculosis (TB) in the northeastern highlands of Peru (CE 800-1535) through the analysis of osseous lesions from Pre-Contact Kuelap, Chachapoyas. METHODS: We examined macroscopic lesion morphology and distribution from the skeletal series (MNI = 207). RESULTS: We determined that skeletal evidence was highly consistent with advanced multifocal and spinal tuberculosis in 13 individuals. Destructive lesions of the lower thoracic and/or lumbar vertebra bodies and sacroiliac joints are evident in most cases, but we also observed lesions within the manubriosternal, hip, and knee joints. Both adult males (n = 7) and females (n = 6) present skeletal lesions from young adult to older adults, but there is only one late adolescent. Only three individuals demonstrate similar lesion distributions. CONCLUSIONS: Variation in lesion distribution in this population-based study shows the importance of identifying extra-vertebral tuberculosis and suggests that the disease may have manifested differently than at other coastal sites. These cases confirm the presence of tuberculosis both before and after Inca occupation across this central Andean highlands region. SIGNIFICANCE: This evidence for the likely endemic presence of TB in the New World prior to European Contact furthers our understanding of the distribution of this infectious disease across the region as well as elucidating lesion distribution. LIMITATIONS: The diagnosis of tuberculosis is based on skeletal lesions and it should be confirmed by molecular analysis. FUTURE RESEARCH: Additional examination of vertebral bodies (including juvenile remains) for evidence of earlier manifestations of infection.

Case Report: Chest Wall Tuberculosis without Pulmonary Involvement in Three Pediatric Immunocompetent Patients.

Primary rib cage tuberculosis (TB) is an infrequent form of presentation and represents 1% of all cases of osteoarticular TB. We report three cases of children who were previously healthy and who began with swelling of the anterior surface of the rib as initial manifestation of TB. The most important clinical presentations in this series were swelling and pain, with lytic lesions and a soft tissue mass in image studies simulating oncologic pathologies. Because none of the cases had positive epidemiological contact, TB was initially not considered, so the delay in diagnosis from the onset of symptoms was 4, 1, and 2 months, respectively. The diagnosis was made through histomorphological analyses. Treatment was administered during 12, 10, and 9 months. Posttreatment studies did not show any evidence of extrapulmonary TB and until date, the patients remained without relapse or active disease. The findings in our cases illustrate that the diagnosis of chest wall TB should be suspected in all patients from endemic areas who present rib injury.

Mycobacterium tuberculosis as a cause of mandibular osteomyelitis in a young woman: a case report.

BACKGROUND: Tuberculosis is considered an emerging disease worldwide; in the last 10 years, its incidence has increased to more than 9.6 million cases of active tuberculosis. In 2014, it resulted in 1.5 million patient deaths. However, oral presentation with bone involvement occurs in less than 3% of all reported cases and rarely arouses clinical suspicion on initial presentation. CASE PRESENTATION: A 15-year-old Mexican girl who had a previous diagnosis of neurofibromatosis presented to our hospital with pain and swelling in the region of the left mandibular body since November 2011. A clinical examination revealed pain in the mandibular region, a mass of soft consistency that seemed to involve bone, and a fistula with discharge of intraoral purulent material. Additionally, tachycardia and hyperthermia were observed. The left submental and submandibular regions had a 12-cm-diameter swelling, which was well-delineated and nonerythematous. The final diagnosis was established by real-time polymerase chain reaction. CONCLUSIONS: The final diagnosis of rare cases of tuberculous osteomyelitis in the jaw can be established by deoxyribonucleic acid (DNA) identification of Mycobacterium tuberculosis in the lesion. Simple and fast complementary diagnosis by real-time polymerase chain reaction is a fundamental approach to establishing early and effective pharmacological and surgical treatment.

Association of tumor necrosis factor-α gene polymorphism with osteoarticular tuberculosis prognosis in a Hebei population.

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction fragment length polymorphism; genotype and allele frequencies were calculated. Serum TNF-α level was significantly higher in OA-TB patients (283.16 ± 51.68 ng/L) than in control (122.54 ± 54.65 ng/L; P < 0.05). Higher frequency of TNF-α-308 GG genotype in healthy volunteers (91.0%) than in OA-TB patients (79.2%) indicated that it was a protective factor against OA-TB (OR = 0.405, 95%CI = 0.147-0.657, P = 0.007). Higher frequencies of TNF-α-308 GA genotype and TNF-α-308 allele (A) in OA-TB patients (20.8 and 10.4%, respectively) than in healthy volunteers (8.0 and 5.0%, respectively) indicated an association with increased risk of OA-TB (OR = 3.112, 95%CI = 1.520-6.343, P = 0.003; OR = 3.109, 95%CI = 1.676-6.538, P = 0.006; respectively). Haplotype association analysis of TNF-α polymorphisms (-308/-238/-863) showed a higher frequency of TNF-α AGA in OA-TB patients (12.1%) than in healthy volunteers (3.5%), indicating that it was a risk factor for OA-TB (OR = 4.201, 95%CI = 1.80-9.91, P = 0.010). TNF-α-308 G/A and TNF-α AGA (-308/-238/-863) were associated with a predisposition to OA-TB, which could aid clinical detection, prevention, and prognosis of OA-TB.

Tuberculosis como causas de osteomielitis en edad pediátrica: a proposito de un caso de osteomielitis en astrágalo / Tuberculosis as a cause of osteomyelitis in childhood: report of a case of osteomylitis of the talus

La osteomielitis hematógena es frecuente en la metáfisis de los huesos largos en la infancia; siendo esta misma afectación rara en otras localizaciones y más aun, extremadamente rara en el astrágalo, tanto así que se reportan solo unos pocos casos y de manera esporádica en la literatura mundial. En este trabajo presentamos un caso clínico, de una paciente preescolar que presento osteomielitis hematógena de astrágalo cuyo tratamiento médico y quirúrgico representaron y aun representan todo un reto para el ejercicio clínico debido a la dificultad del diagnostico etiológico y tórpida evolución.

Hematogenous osteomyelitis is frequent in the metaphysis of long bones in childhood, being the same affection rare in other locations and even more, extremely rare in the talus, so much so that only a few reported sporadic cases and literature world. We present a clinical case of a patient presenting preschool hematogenous osteomyelitis of the talus which medical and surgical treatment represented and still represent a challenge for clinical practice because of the difficulty of diagnostic and torpid evolution.

Tuberculosis de la muñeca y de la mano / Tuberculosis of the hand and wrist

Introducción: La tuberculosis osteoarticular se observa en la columna, la rodilla y la cadera y, menos a menudo,en las vainas tenosinoviales, y en los huesos de la mano y la muñeca. El objetivo del presente trabajo es analizar esta patología y su tratamiento, y valorar la técnica de reconstrucción simultánea a largo plazo. Materiales y métodos: El estudio abarca a 19 pacientes tratados en 45 años, correspondientes a: 3 espinas ventosas, 10 tenosinovitis de flexores, 4 tenosinovitis de extensores y 2 artritis de muñeca. Empleamos una metodología diagnóstica moderna y el estudio retrospectivo de los pacientes, sus tratamientos y resultados. Resultados: El tratamiento farmacológico correcto es eficaz en 99 por ciento de los casos para la infección tuberculosa. El quirúrgico acelera la curación y consiste en la resección de los tejidos necróticos y la reconstrucción funcional, primaria o secundaria. La curación de la infección se logra siempre; la recuperación funcional estará en relación con el tipo, la. gravedad y la extensión de la lesión. Conclusiones: Se demuestra la frecuencia de estas patologías en los trabajadores de la carne o que están en contacto diario con hacienda. Se destacan los procedimientos modernos de diagnóstico. Se enfatiza en un tratamiento médico completo en calidad, duración y tipo de fármacos. Se destacan las bondades de los tratamientos quirúrgicos y de la reconstrucción funcional simultánea que propusimos en 1965.(AU)

Tuberculosis de la muñeca y de la mano / Tuberculosis of the hand and wrist

Introducción: La tuberculosis osteoarticular se observa en la columna, la rodilla y la cadera y, menos a menudo,en las vainas tenosinoviales, y en los huesos de la mano y la muñeca. El objetivo del presente trabajo es analizar esta patología y su tratamiento, y valorar la técnica de reconstrucción simultánea a largo plazo. Materiales y métodos: El estudio abarca a 19 pacientes tratados en 45 años, correspondientes a: 3 espinas ventosas, 10 tenosinovitis de flexores, 4 tenosinovitis de extensores y 2 artritis de muñeca. Empleamos una metodología diagnóstica moderna y el estudio retrospectivo de los pacientes, sus tratamientos y resultados. Resultados: El tratamiento farmacológico correcto es eficaz en 99 por ciento de los casos para la infección tuberculosa. El quirúrgico acelera la curación y consiste en la resección de los tejidos necróticos y la reconstrucción funcional, primaria o secundaria. La curación de la infección se logra siempre; la recuperación funcional estará en relación con el tipo, la. gravedad y la extensión de la lesión. Conclusiones: Se demuestra la frecuencia de estas patologías en los trabajadores de la carne o que están en contacto diario con hacienda. Se destacan los procedimientos modernos de diagnóstico. Se enfatiza en un tratamiento médico completo en calidad, duración y tipo de fármacos. Se destacan las bondades de los tratamientos quirúrgicos y de la reconstrucción funcional simultánea que propusimos en 1965.

Importância da artroscopia no diagnóstico e tratamento da tuberculose no ombro / The importance of arthroscopy in the diagnosis and treatment of tuberculosis in the shoulder

Objetivo: Descrever um caso de infecção por Mycobacterium tuberculosis, comprometendo ombro esquerdo de paciente do sexo masculino, com 24 anos de idade, que referia dor constante, difusa, sem irradiações e fatores de melhora ou piora. A dor se iniciou espontaneamente há três meses, sem história traumática. Métodos: A radiografia de ombro esquerdo não revelou anormalidades e a ressonância magnética da articulação indicou imagem sugestiva de lesão do lábio superior da glenoide. Após tratamento inicial conservador com uso de anti-inflamatório não hormonal e fisioterapia, sem sucesso, foi realizada artroscopia da articulação acometida, desbridando os tecidos inflamados e realizando-se ressecção de material para exame anatomopatológico, o qual teve como resultado granulomas sugestivos de infecção por Mycobacterium tuberculosis. O diagnóstico foi confirmado por pesquisa de infecção por micobactérias. Foi realizada antibioticoterapia específica para tuberculose, havendo regressão completa do quadro após o término do tratamento. Conclusão: O trabalho destaca a importância do método artroscópico no diagnóstico e tratamento dessa lesão do ombro.

[Calvarial tuberculosis: case report]. / Tuberculose óssea craniana: relato de caso.

Tuberculosis is endemic in developing countries. However, calvarial tuberculosis is rare and only few cases have been reported with computed tomographic findings. We report on a 49-year-old woman with a occipital painless nodule. The microscopic examination indicated typical tuberculosis granulomas. Clinical presentation and management are discussed.

Tuberculous osteomyelitis presenting as shoulder pain.

A case of tuberculous osteomyelitis of the proximal humerus is described. The relevant literature is reviewed with attention to epidemiologic data. Issues highlighted include the frequent presentation in a subacute course without systemic illness; the value of plain radiography and especially magnetic resonance imaging; the importance of obtaining a tissue diagnosis; and the high rate of cure with medical therapy. Although rare in Western countries, skeletal tuberculosis is not uncommon in endemic areas and in migrants from such areas. With the growing use of biologic therapies, rheumatologists must be familiar with the diagnosis and treatment of tuberculosis in all its forms.

[Tuberculosis bursitis: report of case]. / Bursitis tuberculosa: caso clínico.

We report a previously healthy 51 years old woman with a one year history of pain in the left hip associated with a mass without fever or local inflammatory changes. Magnetic resonance imaging located the mass in the medial gluteal muscle. The pathological examination of the mass disclosed unspecific inflammatory changes. Due to worsening of pain, a left throchanteric bursitis was diagnosed two weeks later and a throchanteric bursectomy was performed, obtaining a second biopsy. Aerobic, anaerobic and fungal cultures were negative. Lowenstein-Jensen culture showed development of mycobacteria and a genetic probe confirmed the presence of Mycobacterium tuberculosis. The second biopsy also identified several granulomas with areas of caseation and the Ziehl-Nielsen stain was positive for acid fast bacilli. Osteoarticular tuberculosis, specially bursitis, should be suspected in the presence of chronic pain associated with swelling.

Pre-Columbian tuberculosis in northern Chile: molecular and skeletal evidence.

Analysis of 483 skeletons from Arica (Chile) and review of mummy dissection records demonstrates an overall 1% prevalence rate for tuberculosis between 2000 B.C. and A.D. 1500. Tuberculosis cases cluster in the period A.D. 500-1000 which correlates with fully agropastoral societies. Considering only these agropastoral societies, about 2% of their members show tuberculosis lesions. A segment of DNA unique to Mycobacterium tuberculosis was identified in an extract from the vertebral lesion of a 12-year-old girl with Pott's disease from about A.D. 1000, establishing the pre-Columbian presence of tuberculosis with the most specific evidence currently available.

Papel del dermatologo en la tuberculosis osteoarticular / The dermatologist role in the osteoarticular tuberculosis

Se presenta un paciente de sexo masculino, de 62 años de edad, que comenzó su enfermedad con una lesión sobreelevada roja de 0,5x0,5 cm de diámetro en dorso de mano izquierda, de aspecto verrugoso que fue creciendo paulatinamente en forma centrífuga, con atrofia en la zona central y con desarrollo de múltiples bocas fistulosas. Simultáneamente se observó compromiso progresivo y destrucción de la articulación metacarpo falángica. Se efectuaron los correspondientes estudios de laboratorio Rx., biopsias y cultivos, encontrándose como resultado BAAR por lo que se diagnosticó una TBC ósteoarticular con compromiso cutáneo. Se realizó el tratamiento antituberculoso correspondiente, observándose la mejoria cutánea, pero el empeoramiento del cuadro ósteoarticular. Se realiza una revisión del tema, haciendo hincapié en el papel que juega el dermatólogo en el diagnóstico precoz y efectividad terapéutica futura en la TBC ósteoarticular, a partir de sus manifestaciones cutáneas. Se hace referencia, en esta variedad de TBC, a la dificultad que se tiene para confirmar el diagnóstico y la necesidad de instituir un tratamiento médico-quirúrgico temprano si se quieren evitar terapéuticas quirúrgicas invalidantes

Papel del dermatologo en la tuberculosis osteoarticular / The dermatologist role in the osteoarticular tuberculosis

Se presenta un paciente de sexo masculino, de 62 años de edad, que comenzó su enfermedad con una lesión sobreelevada roja de 0,5x0,5 cm de diámetro en dorso de mano izquierda, de aspecto verrugoso que fue creciendo paulatinamente en forma centrífuga, con atrofia en la zona central y con desarrollo de múltiples bocas fistulosas. Simultáneamente se observó compromiso progresivo y destrucción de la articulación metacarpo falángica. Se efectuaron los correspondientes estudios de laboratorio Rx., biopsias y cultivos, encontrándose como resultado BAAR por lo que se diagnosticó una TBC ósteoarticular con compromiso cutáneo. Se realizó el tratamiento antituberculoso correspondiente, observándose la mejoria cutánea, pero el empeoramiento del cuadro ósteoarticular. Se realiza una revisión del tema, haciendo hincapié en el papel que juega el dermatólogo en el diagnóstico precoz y efectividad terapéutica futura en la TBC ósteoarticular, a partir de sus manifestaciones cutáneas. Se hace referencia, en esta variedad de TBC, a la dificultad que se tiene para confirmar el diagnóstico y la necesidad de instituir un tratamiento médico-quirúrgico temprano si se quieren evitar terapéuticas quirúrgicas invalidantes (AU)

Tuberculose cutânea associada à tuberculose osteoarticular / Cutaneous tuberculosis associated with osteoarticular tuberculosis

Devido à raridade da associaçäo e à dificuldade diagnóstica, apresenta-se um caso de tuberculose cutânea do tipo coliquativa, provocada por extensäo direta de foco osteoarticular de ambas as clavículas e de foco ósseo de costelas. A tuberculose osteoarticular da paciente foi provavelmente produzida por disseminaçäo hematogênica de foco tuberculoso pulmonar