1.
Bioorg Chem
; 90: 103100, 2019 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31288136
RESUMO
In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Most phthalocyanines exhibited good inhibitory activities on these enzymes. Among the six phthalocyanines and starting compounds, 4a showed the most interesting profile as a submicromolar selective inhibitor of AChE (IC50â¯=â¯0.040⯵M) and 5a showed the most effective inhibitor of BChE (IC50â¯=â¯0.1198⯵M).