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1.
Int J Dermatol ; 62(2): 202-211, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36281828

RESUMO

BACKGROUND: A broad spectrum of skin diseases, including hair and nails, can be directly or indirectly triggered by COVID-19. It is aimed to examine the type and frequency of hair and nail disorders after COVID-19 infection. METHODS: This is a multicenter study conducted on consecutive 2171 post-COVID-19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined. RESULTS: The rate of the previous admission in hospital due to COVID-19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID-19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID-19 infection. The mean stress scores during and after getting infected with COVID-19 were 6.88 ± 2.77 and 3.64 ± 3.04, respectively, in the hair loss group and were 5.77 ± 3.18 and 2.81 ± 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID-19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4-7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222-7.027]). The most common nail disorders were leukonychia, onycholysis, Beau's lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID-19 were statistically significantly more common in patients having nail disorders after getting infected with COVID-19 when compared to the control group (P < 0.05). CONCLUSION: The development of both nail and hair disorders after COVID-19 seems to be related to a history of severe COVID-19.


Assuntos
Alopecia em Áreas , COVID-19 , Doenças da Unha , Unhas Malformadas , Masculino , Humanos , COVID-19/complicações , COVID-19/epidemiologia , Doenças da Unha/epidemiologia , Doenças da Unha/etiologia , Doenças da Unha/diagnóstico , Unhas , Alopecia/epidemiologia , Alopecia/etiologia , Cabelo
2.
Clin Dermatol ; 37(3): 182-191, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31178101

RESUMO

Despite advances in the control, diagnosis, and treatment of syphilis, its recognition is ill- understood or often not considered by dermatologists and other physicians who either have little specialized training in the minutiae of sexually transmitted infections (STIs) or whose dermatologic practice is only occasionally consulted by individuals from communities where STIs are prevalent. Our aim is to highlight contemporary ideas and findings on syphilis so that not only is an accurate diagnosis of syphilis made and recognized treatment given, but also necessary measures, such as counseling to exclude other STIs and to prevent reinfection, partner notification, and public health epidemiology as for any other infectious disease, are not forgotten. For syphilis, like human immunodeficiency virus (HIV) infection, not only is the biomedical aspect important, but also are the social and psychologic components.


Assuntos
Sífilis , Alopecia/etiologia , Diagnóstico Diferencial , Doxiciclina/administração & dosagem , Feminino , Infecções por HIV , Humanos , Infusões Intravenosas , Injeções Intramusculares , Masculino , Mucosa/patologia , Neurossífilis , Penicilina G Benzatina/administração & dosagem , Gravidez , Prevenção Secundária , Pele/patologia , Sífilis/diagnóstico , Sífilis/tratamento farmacológico , Sífilis/patologia , Sífilis/transmissão , Sorodiagnóstico da Sífilis/métodos , Tetraciclina/administração & dosagem
3.
Postepy Dermatol Alergol ; 34(5): 464-467, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29507562

RESUMO

INTRODUCTION: The role of oxidative stress in the pathogenesis of psoriasis has been investigated in previous studies with conflicting results. On the other hand, well-established treatments currently used in psoriasis exert their effects via a boost of oxidative stress. Recently, a strong positive association between psoriasis, metabolic syndrome and dyslipidemia has also been described showing the complex nature of the disease. AIM: To examine thiol/disulphide homeostasis, a newly developed homeostasis assay in psoriasis and evaluate the possible association between thiol/disulphide homeostasis and dyslipidemia in psoriasis. MATERIAL AND METHODS: The study population included 92 psoriasis patients and 71 healthy subjects. Serum native thiol, total thiol and disulphide levels were investigated in patients with psoriasis and in healthy subjects. In addition, lipid profile (serum total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) levels were investigated in both groups. The association between thiol-disulphide parameters and dyslipidemia was also evaluated. RESULTS: Serum total cholesterol and triglyceride levels were found to be higher in patients with psoriasis than in the healthy group. Lower plasma disulphide and higher native thiol levels were found in patients with psoriasis indicating an antioxidant status. CONCLUSIONS: To our knowledge, this is the first study showing the shift of dynamic thiol/disulphide homeostasis towards the thiol form in psoriasis which indicate higher antioxidant status.

4.
Acta Dermatovenerol Croat ; 24(4): 291-295, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28128081

RESUMO

Pigmented purpuric dermatoses (PPD) are a group of chronic and relapsing cutaneous disorders characterized by a distinct purpuric rash. The diagnosis is made with clinical and histopathological findings. Dermoscopy has rarely been used in the diagnosis of PPD. The aim of our study is to describe the dermoscopic findings in patients with PPD. Eighteen patients who were clinically and histopathologically diagnosed with PPD were studied prospectively. The type and duration of PPD, associated diseases, and medication history of the patients were noted. Dermoscopic examination was performed in all of the patients. Four of the patients were women and 14 of them were men. 16 (88.8%) of them had Shamberg's disease, 1 of them had lichen aureus, and 1 had purpura annularis telangiectoides. Dermoscopic examination revealed multiple irregular red dots, globules and/or patches and brown-coppery coloration on the background in all of the patients, a network of interconnected brown lines in 8, linear vessels in 9, brown dots in 3, grey dots in 3, twisted red loops in 5, comma-like vessels in 2, and red lacunae in 1 patient. The dermoscopic examination of PPD might improve the accuracy of clinical diagnosis.


Assuntos
Dermoscopia/métodos , Transtornos da Pigmentação/epidemiologia , Transtornos da Pigmentação/patologia , Púrpura/epidemiologia , Púrpura/patologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Estudos de Coortes , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Transtornos da Pigmentação/diagnóstico , Prognóstico , Estudos Prospectivos , Púrpura/diagnóstico , Doenças Raras , Estudos de Amostragem , Índice de Gravidade de Doença , Distribuição por Sexo , Turquia , Adulto Jovem
6.
Postepy Dermatol Alergol ; 32(5): 327-30, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26759539

RESUMO

INTRODUCTION: Melasma is a common chronic, acquired pigmentation disorder with a significant impact on the quality of life of patients. AIM: To investigate the etiopathogenetic factors, thyroid functions and thyroid autoimmunity in patients with melasma. MATERIAL AND METHODS: Forty-five women with melasma and 45 age-matched healthy women were included in the study group. A detailed history was taken from the patients including triggering factors of melasma. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), anti-thyroglobulin (AbTG) and anti-thyroid peroxidase (Ab-TPO) were measured and thyroid ultrasonography was performed for each subject. RESULTS: In 26.7% of patients, pregnancy, in 17.8%, oral contraceptive use and in 13.3%, intense sunlight exposure were the triggering factors. 17.8% of patients had a family history of melasma. FT4, TSH and AbTG levels were significantly higher in the patient group. CONCLUSIONS: The results suggest that a combination of factors including pregnancy, oral contraceptive use, sunlight and genetic factors often trigger melasma. Thyroid hormones and thyroid autoimmunity may also play a role in the pathogenesis which needs to be proven by further studies.

7.
Cutan Ocul Toxicol ; 33(1): 74-5, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23638882

RESUMO

Many people widely use herbal therapies for health problems in the world. Although these herbal therapies sometimes may be useful for some disorders they are not risk free. Ceratocephalus falcatus is an annual, wild plant which is a member of Ranunculaceae family. There are few case reports of phytodermatitis due to the Ranunculaceae family. We present a 58-year-old woman with irritant phytodermatitis due to C. falcatus.


Assuntos
Dermatite de Contato/etiologia , Preparações de Plantas/efeitos adversos , Ranunculaceae/química , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Artralgia/tratamento farmacológico , Dermatite de Contato/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade , Curativos Oclusivos , Preparações de Plantas/administração & dosagem , Preparações de Plantas/uso terapêutico , Resultado do Tratamento , Cicatrização/efeitos dos fármacos , Cicatrização/fisiologia
10.
Postepy Dermatol Alergol ; 30(4): 265-7, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24278086

RESUMO

A 76-year-old white man presented with severe pruritic eruption on both of the extremities and lumbar area for 2 years. The dermatological examination showed multiple, 1-2 mm sized, hyperpigmented and hyperkeratotic papules which coalesced to form poorly delineated plaques spread on the lumbosacral area, lateral and extensor surfaces of thighs, arms and forearms. The histopathological examination revealed eosinophilic amorphous material in papillary dermis that was stained positively with crystal violet stain. The patient was diagnosed as generalized lichen amyloidosis (LA) clinically and histopathologically. Routine laboratory tests were within normal limits except thyroid function tests. The thyroid stimulating hormone level was decreased, while the thyroxine level was increased. Ultrasonography showed enlarged and heterogeneous thyroid gland. Thyroid autoantibodies were within normal limits. An association between LA and other diseases such as atopic dermatitis, lichen planus, mycosis fungoides, chronic urticaria, HIV infection, multiple endocrine neoplasia type 2A, and angiolymphoid hyperplasia with eosinophilia have been defined. However, there is no reported LA case associated with hyperthyroidism in the literature. We think that the same etiologic factor might have triggered both diseases, or hyperthyroidism, by causing the itching, might have induced the occurrence or spread of LA.

11.
Pediatr Dermatol ; 30(5): e100-1, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23627703

RESUMO

A 14-year-old girl presented with hyperkeratotic, pitted, skin-colored papules on a slightly erythematous surface on her palms and erythematous and squamous papules around her ankles. She was clinically and histopathologically diagnosed with lichen nitidus, which is observed rarely on the palms.


Assuntos
Dermatoses da Mão/diagnóstico , Dermatoses da Mão/patologia , Líquen Nítido/diagnóstico , Líquen Nítido/patologia , Adolescente , Tornozelo/patologia , Biópsia , Feminino , Mãos/patologia , Humanos
12.
Inflamm Allergy Drug Targets ; 12(2): 132-46, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23360252

RESUMO

Intravenous immunoglobulin (IVIG) is a fractioned blood product consisting of IgG antibodies which was first used in antibody deficiency disorders. It is increasingly being used for several inflammatory and autoimmune conditions. IVIG can also be used in a wide range of dermatological diseases which are difficult to treat including autoimmune bullous skin diseases and toxic epidermal necrolysis. The use of IVIG in dermatological disorders is discussed in this article.


Assuntos
Imunização Passiva/métodos , Imunoglobulinas Intravenosas/administração & dosagem , Dermatopatias/tratamento farmacológico , Dermatologia/métodos , Humanos
13.
Inflamm Allergy Drug Targets ; 11(6): 422-32, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22680624

RESUMO

Pentoxifylline is methylxanthine derivative which is used in microcirculatory disorders as a vasoactive drug. Novel immunomodulatory properties of pentoxifylline have been reported including the down regulation of tumour necrosis factor-α synthesis and other inflammatory cytokines. Studies have shown that pentoxifylline might be efficacious in a wide spectrum of skin diseases. This article focuses on the use of pentoxifylline which is a safe and cheap drug in various dermatological disorders.


Assuntos
Pentoxifilina/uso terapêutico , Inibidores de Fosfodiesterase/uso terapêutico , Dermatopatias/tratamento farmacológico , Animais , Citocinas/metabolismo , Regulação para Baixo/efeitos dos fármacos , Custos de Medicamentos , Humanos , Microcirculação/efeitos dos fármacos , Pentoxifilina/economia , Pentoxifilina/farmacologia , Inibidores de Fosfodiesterase/economia , Inibidores de Fosfodiesterase/farmacologia , Dermatopatias/fisiopatologia , Fator de Necrose Tumoral alfa/biossíntese , Fator de Necrose Tumoral alfa/efeitos dos fármacos
14.
J Dermatol Case Rep ; 5(4): 64-8, 2011 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-22408705

RESUMO

BACKGROUND: Epidemiologic researches about oral mucosal lesions have been performed in different populations. But, in dermatology outpatients, oral mucosal lesions have not been investigated previously. OBJECTIVE: We aimed to determine the prevalence of oral mucosal lesions among dermatology outpatients and the relationship between OML and smoking, alcohol intake, denture and dental filling use and skin diseases. METHODS: Randomly selected 1041 dermatology outpatients were examined for dermatological diseases and oral mucosal lesions. All of the patients were questioned about smoking, alcohol intake, denture and dental filling use. RESULTS: In 235 patients, oral mucosal lesions were recorded. 268 (25.7%) of the patients had history of smoking, 42 (4%) drinking alcohol and 180 (17.3%) denture and dental filling. 32 (64%) of the smokers, 54 (30%) of denture users and 10 (23.8%) alcohol consumers had at least one OML. Age and smoking were found as significant risk factors for oral mucosal lesions. Fissured tongue was the most common oral lesion and it was seen significantly higher in patients with denture. Smoking was risk factor for coated tongue and linea alba. CONCLUSIONS: Oral mucosa should be examined carefully even if the patients do not attend with the complaint of oral lesions, especially in elderly patients, smokers and denture users.

19.
Adv Skin Wound Care ; 22(9): 412-5, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19713777

RESUMO

BACKGROUND: Pressure ulcers (PrUs) remain a common problem in all healthcare settings. The aim of this study was to assess the presence of risk factors in patients with PrUs. METHODS: The study included 32 immobilized inpatients with PrUs and 30 immobilized inpatients without PrUs as a control group, who were being followed up at the Ankara Physical Therapy and Rehabilitation Hospital, Ankara, Turkey. Patients were given physical examinations and assessed for medical history, as well as for associated diseases, the duration of PrUs, the presence of stool and urinary incontinence, the use of pressure-reducing bed surface, and change of position. Routine biochemical and hematologic blood examinations were performed in all of the patients involved in the study. RESULTS: When risk factors for PrUs were assessed, 81.2% of the patients with PrUs had stool and urine incontinence, 46.8% had been smoking, 46.8% had hypoalbuminemia, 15.6% had been drinking alcohol, and 9.3% had diabetes; 18.7% had been using a pressure-reducing bed surface before the ulcer appeared, and 40.6% started to use a pressure-reducing bed surface after the ulceration occurred; and 59.3% were repositioned periodically. PrUs were found to develop earlier in patients who were smoking and who had anemia. A significant relation also was found between the grade of the ulcer and the frequency of change of position in bed. Smoking and urinary/stool incontinence were found to be significantly present more frequently in the patient group than the control group. Stool incontinence and the absence of the use of a pressure-reducing bed were also found to be risk factors in the patient group when compared with the control group. CONCLUSIONS: The authors believe that stool and urinary incontinence, smoking, anemia, not using a pressure-reducing bed surface, and infrequent change of position in bed are considerable risk factors for the development of PrUs. Immobilized patients should be assessed for these risk factors, and measures should be taken to prevent PrU development.


Assuntos
Imobilização/efeitos adversos , Úlcera por Pressão/prevenção & controle , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Intervalos de Confiança , Feminino , Humanos , Pacientes Internados , Masculino , Pessoa de Meia-Idade , Razão de Chances , Úlcera por Pressão/epidemiologia , Úlcera por Pressão/etiologia , Fatores de Risco , Estatística como Assunto , Turquia/epidemiologia , Adulto Jovem
20.
Am J Clin Dermatol ; 10(5): 336-8, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19658447

RESUMO

A 30-year-old man presented with indurated violaceous plaques all over his body that had been present for 7 months. The patient had also had vitiligo for 3.5 years, and hepatitis B virus (HBV) infection and cirrhosis for a 2-year period. Histopathologic examination of the indurated plaques confirmed the diagnosis of morphea. Localized scleroderma and vitiligo have only rarely been reported to occur simultaneously. Although the etiologies of vitiligo and morphea are both uncertain, their association with autoimmune diseases favors an autoimmune hypothesis. Both vitiligo and morphea might have appeared coincidentally. However, this association could be significant because it may be related to the presence of HBV and alterations in the immune system that are caused by this virus. Therefore, this rare combination of vitiligo and morphea in a patient with chronic HBV infection warrants attention because it suggests a possible immunologic association, which may merit future study.


Assuntos
Hepatite B Crônica/complicações , Esclerodermia Localizada/etiologia , Vitiligo/etiologia , Adulto , Autoimunidade , Hepatite B Crônica/imunologia , Humanos , Sistema Imunitário/virologia , Masculino , Esclerodermia Localizada/imunologia , Vitiligo/imunologia
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