[Clinical effectiveness of combination treatment with α1-adrenoblokator and type 5 phosphodiesterase inhibitor for patients of advanced and senile age suffering from lower urinary tract symptoms.]

The results of the pilot study are presented, the main purpose of which was to assess the effectiveness and safety of the combined application of α-adrenoblocator and type 5 phosphodiesterase inhibitor for the treatment of patients with symptoms of the lower urinary tract of old and old age. The study involved 60 patients over 50 years of age having middle-severe lower urinary tract symptoms, erectile dysfunction, moderately pronounced infravesical obstruction, prostate volume greater than 30 cc and prostate-specific antigen levels less than 4 ng/ml. The duration of treatment in all groups was 6 months. The study participants were divided into three groups, comparable in age, clinical manifestations and laboratory-instrumental indicators: Group 1 patients received type 5 phosphodiesterase inhibitor daily, group 2 patients - α1-adrenoblocator, group 3 - α1-adrenoblocator and type 5 phosphodiesterase inhibitor. A clinical study showed that long-term combination treatment of lower urinary tract symptoms α1-adrenoblocator and type 5 phosphodiesterase inhibitor in elderly and senile patients proved to be effective, well tolerated and hardly caused side reactions, significantly improving quality of life.

[Features of urolithiasis in patients of advanced and senile age.]

There were 105 patients of different gender of elderly and senile age with urolithiasis. The entire contingent of patients with ICD was divided into 2 groups: the main group (55 people aged 61-85 years) and the comparison group (50 people aged 40-60). All patients went throught a general clinical examination: a detailed history of the anamnesis, an objective examination, laboratory and instrumental methods of investigation. It was revealed that in patients of elderly and senile age the clinical picture is more worn out, the renal colic is less often registered; more significant metabolic disorders that can participate in stone formation. Among the concomitant pathology in patients of this age category, a special role is assigned to: hypertension, diabetes, gout, chronic pyelonephritis and benign prostatic hyperplasia. According to the data of echographic and X-ray studies of these patient groups, it is noted that in patients aged 61-85 years, the calculi of the kidneys reach large sizes in comparison with patients 40-60 years old, and the main localization of stones in the ureter is its lower third.