Toward Next-Generation Phenomics: Precision Medicine, Spaceflight, Astronaut Omics, and Beyond.

Large investments over many decades in genomics in diverse fields such as precision medicine, plant biology, and recently, in space life science research and astronaut omics were not accompanied by a commensurate focus on high-throughput and granular characterization of phenotypes, thus resulting in a "phenomics lag" in systems science. There are also limits to what can be achieved through increases in sample sizes in genotype-phenotype association studies without commensurate advances in phenomics. These challenges beg a question. What might next-generation phenomics look like, given that the Internet of Things and artificial intelligence offer prospects and challenges for high-throughput digital phenotyping as a key component of next-generation phenomics? While attempting to answer this question, I also reflect on governance of digital technology and next-generation phenomics. I argue that it is timely to broaden the technical discourses through a lens of political theory. In this context, this analysis briefly engages with the recent book "The Earthly Community: Reflections on the Last Utopia," written by the historian and political theorist Achille Mbembe. The question posed by the book, "Will we be able to invent different modes of measuring that might open up the possibility of a different aesthetics, a different politics of inhabiting the Earth, of repairing and sharing the planet?" is directly relevant to healing of human diseases in ways that are cognizant of the interdependency of human and nonhuman animal health, and critical and historically informed governance of digital technologies that promise to benefit next-generation phenomics.

Global Governance for Personalized Medicine, Politics of Uncertainty, and Pierre Bourdieu.

How we choose to respond to uncertainty matters for robust and responsible science. New laws and consensus reports are popular instruments for global governance of emerging technology and attendant uncertainty. However, the sociologist Pierre Bourdieu noted that "[t]he judicial situation operates like a neutral space that neutralizes the stakes in any conflict through the de-realization and distancing implicit in the conversion of a direct struggle between parties into a dialogue between mediators." Put in other words, while law and legal modes of reasoning are certainly useful for conflict resolution and closure, their overprivileging in emerging technology and uncertainty governance can potentially bring about depoliticization by transforming the struggles and dissent necessary for democratic governance into a "dialogue between mediators." Hence, the critical sociological gaze offered by Bourdieu is particularly relevant for democratization of global governance of multiomics technologies and timely with the current uptake of personalized medicine. For example, in May 2023, the Romanian government introduced a law to give patients the right to personalized medicine. Personalized medicine is related to the larger umbrella concept and field of theranostics, the fusion of therapeutics and diagnostics. It is therefore timely to reflect on a "right for theranostics in planetary health," considering the potential for future pandemics and ecological crises in the 21st century. Rather than forcing consensus or convergence in an innovation ecosystem, dissent grounded in rigorous political theory, sociology of law and critical legal studies can strengthen democratization and global governance for personalized medicine and multiomics technologies.

Technological Encounters in a Knowledge Economy: An Epistemic X-Ray.

Climate emergency is a planetary health and systems science challenge because human health, nonhuman animal health, and the health of the planetary ecosystems are coproduced and interdependent. Yet, we live in a time when climate emergency is tackled by platitudes and weak reforms instead of structural and systems changes, and with tools of the very same systems and metanarratives, for example, infinite growth at all costs, that are causing climate change in the first place. Seeking solutions to problems from within the knowledge frames and metanarratives that are causing the problems reproduces the same problems across time and geographies. This article examines and underlines the importance of an epistemological gaze on knowledge economy, an epistemological X-ray, as another solution in the toolbox of decolonial and other social justice struggles in an era of climate emergency. Epistemology questions and excavates the metanarratives embedded in knowledge forms that are popular, dominant, and hegemonic as well as knowledges that are silent, omitted, or erased. In this sense, epistemology does not take the "archives" of data and knowledge for granted but asks questions such as who, when, how, and with what and whose funding the archive was built, and what is included and left out? Epistemological choices made by innovators, funders, and knowledge actors often remain opaque in knowledge economies. Epistemology research is crucial for science and innovations to be responsive to planetary society and climate emergency and mindful of the social, political, neocolonial, and historical contexts of science and technology in the 21st century.

Taking Political Determinants of Planetary Health Seriously: Expanding from P4 to P5 Medicine.

Predictive, Personalized, Preventive, and Participatory (P4) Medicine is embedded in the precision medicine conceptual framework to achieve the overarching goal of "the right drug, for the right patient, at the right dose, and at the right time." Science cultures and political determinants of health have normative and instrumental impacts on P4 medicine. Yet, since the age of Enlightenment in the 17th century, science and economics have been disarticulated from politics along the lines of classical liberalism, and with an ahistorical approach that continues into the 21st century. The consequence of this liberal disarticulation is that science is falsely and narrowly understood as an invariably technocratic and objective field. In the aftermath of the Covid-19 pandemic, it is clearer that political determinants of health are the causes-of-causes for disease and health. I propose that we need P5 medicine with a fifth P, political determinants of planetary health. The new "P" can engage not only with instrumental aspects of P4 medicine research and clinical implementation but also with the structural factors that are an integral part of the politics of the P4 medicine. For example, the living legacies of colonialism contribute to the unequal relationships in trade, labor, provision, and production of materials among nation-states and between the Global South and the Global North and shape the class struggles in contemporary society, science, and medicine. A decolonial politics of care in which the political determinants of planetary health are taken seriously is therefore crucial and relevant to building a robust, ethical, responsible, and just P5 medicine in the 21st century.

Feminism Is for Everyone: Scientists, Too.

Critically informed engagement in politics and the knowledge of social theory help democratize knowledge production, and redress power asymmetries in science and society. A feminist lens is one of the many ways in which power asymmetries in science can be critically unpacked and interrupted. There are many strands of feminism and feminist theory that differ in their approaches to resist patriarchy and injustices in science and society. As an example, I adopt here the definition of feminism of the late cultural critic bell hooks because her works underscore that feminism is an intersectional liberatory methodology for everyone to resist multiple forms of oppression simultaneously. Queer theory is a strand of social theory that came to prominence since the 1990s in particular. Queer feminism continues to shape feminist writing on science cultures and the knowledge-based innovations contemporary science strives to accomplish. Systems science brings about systems thinking, and that includes rethinking science as culture beyond a narrow realm of technology, and being cognizant of the broader social, feminist, queer, and political contexts of science around the world.

Narrative Metadata: Leaving the War Metaphor Behind and Unpacking the Control Tactics of Biopower in COVID-19.

Narratives are a veritable type of metadata. Narratives are power-laden storylines that conjure up emotions and enact value systems that markedly affect scientific practices, and to what ends, and for whom science and health innovations are made available. Narratives, if they are left unchecked, can undermine critical thinking and the agency of publics, threatening the possibilities for robust, responsible, relevant, and democratic science. One such narrative, a sociotechnical metadata in its own right, and of immense relevance in the current historical moment of the pandemic, is the uncritical use of the war and other military metaphors in COVID-19 science and planetary health interventions. In October 2022 issue of OMICS, Ebru Yetiskin adopts a biophilosophical transdisciplinary approach and feminist versions of science and technology studies to examine the ways in which the war discourse and other military metaphors have been deployed for the sake of biopower during COVID-19. In this article, we discuss the need to critically unpack the narrative metadata to leave the war metaphor behind, and hold to account the control tactics of biopower embedded in the COVID-19 pandemic.

Decolonizing Knowledge Upstream: New Ways to Deconstruct and Fight Disinformation in an Era of COVID-19, Extreme Digital Transformation, and Climate Emergency.

Lies and disinformation have always existed throughout human history. However, disinformation has become a "pandemic within a pandemic" with convergence of COVID-19 and digital transformation of health care, climate emergency, and pervasive human-computer interaction in all facets of life. We are living through an era of post-truth. New approaches to fight disinformation are urgently needed and of paramount importance for systems science and planetary health. In this study, we discuss the ways in which extractive and entrenched epistemologies such as technocracy and neoliberalism co-produce disinformation. We draw from the works of David Collingridge in technology entrenchment and the literature on digital health, international affairs, climate emergency, degrowth, and decolonializing methodologies. We expand the vocabulary on and interventions against disinformation, and propose the following: (1) rapid epistemic disobedience as a critical governance tool to resist the cultural hegemony of neoliberalism and its master narrative infinite growth that is damaging the planetary ecosystems, while creating echo chambers overflowing with disinformation, and (2) a two-tiered taxonomy of reflexivity, a state of self-cognizance by knowledge actors, for example, scientists, engineers, and physicians (type 1 reflexivity), as well as by chroniclers of former actors, for example, civil society organizations, journalists, social sciences, and humanities scholars (type 2 reflexivity). This article takes seriously the role of master narratives in quotidian life in production of disinformation and ecological breakdown. The infinite growth narrative does not ask critical questions such as "growth in what, at what costs to society and environment?," and is a dangerous game of brinkmanship that has been testing the planetary ecological boundaries and putting at risk the veracity of knowledge. There is a need for scholars and systems scientists who break ranks with entrenched narratives that pose existential threats to planetary sustainability and are harmful to knowledge veracity. Scholars who resist the obvious recklessness and juggernaut of the pursuit of neoliberal infinite growth would be rooting for living responsibly and in solidarity on a planet with finite resources. The interventions proposed in this study, rapid epistemic disobedience and the expanded reflexivity taxonomy, can advance progressive policies for a good life for all within planetary boundaries, and decolonize knowledge from disinformation in ways that are necessarily upstream, radical, rapid, and emancipatory.

Disinformation as COVID-19's Twin Pandemic: False Equivalences, Entrenched Epistemologies, and Causes-of-Causes.

We are currently facing and traversing in the thick of a twin pandemic: coronavirus disease 2019 (COVID-19) and disinformation. Disinformation is false information created and spread deliberately with the intention to mislead public opinion, obscure truths, and undermine trust in knowledge. The digital age we live in is quite different than the printing revolution and invention of the oil-based ink printing press centuries ago. Digital technologies can spread and repeat disinformation at extremely high speeds, while anyone, a qualified expert or not, and with internet access, can become an author. To fight disinformation, we ought to dismantle the entrenched and extractive epistemologies that act as upstream drivers and sites of disinformation production. Epistemology refers to the value-laden knowledge frames, overarching master narratives, and storylines, in which knowledge is produced. If the epistemologies in which we generate knowledge are false, then the knowledge products will be laden with disinformation. Moreover, the harms caused by disinformation can extend well beyond the immediate knowledge domain where disinformation has originated. This occurs when "false equivalence" is used as a form of rhetoric. False equivalence is a type of flawed sense making where equal weight is given to arguments with concrete material evidence, and those that are conjecture, untrue, or unjust. This article presents an analysis of the disinformation pandemic attendant to COVID-19, with an eye to its causes-of-causes: unchecked extractive epistemologies (e.g., technocracy), and the practice of false equivalence in pandemic discourses. We argue that holding the political agency of master narratives to account is essential (1) to fight the disinformation pandemic and (2) for prefigurative politics to build egalitarian and democratic societies in place of the instrumental/transactional relationships that typify the contemporary nation states and the neoliberal university whose ossified rituals lack the normative capacities for critical governance in a time of converging social, digital, and ecological crises. For liberation from disinformation, we should start with liberation from entrenched extractive epistemologies in science and society.

The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones in rats with hypothyroidism and hyperthyroidism.

In our study, the effect of essential oil obtained from Nigella sativa L. (NSE) on thyroid hormones and antioxidant balance in hypothyroidism (HT) and hyperthyroidism (HP) models induced by propylthiouracil(PTU) and L-thyroxine(LT4 ), respectively, in rats were investigated for 4 weeks. NSE was administered by gastric gavage at a dose of 200 mg/kg body weight. In this study, 48 male Wistar albino rats with an average weight of 180-290 g and age 5-6 months were divided into eight groups, as follows: groups with HT, (1) control, (2) HT, (3) NSE, and (4) HT + NSE; groups with HP, (1) control, (2) HP, (3), and NSE (4) HP + NSE. As a result, we found that NSE administration increased total triiodothyronine (TT3 ) and decreased nitric oxide in HT + NSE. Besides, it decreased TT3 in HP + NSE and increased total antioxidant capacity. Our findings suggest that NSE may have beneficial effects on thyroid gland abnormalities owing to its antioxidant properties. PRACTICAL APPLICATIONS: Essential oils derived from Nigella sativa L. seed contain many bioactive substances such as thymoquinone and cymene. This paper emphasizes the effect of NSE on thyroid hormone abnormalities and negative oxidative state that occurs in HT and HP models. The present study provides evidence of a positive effect of NSE particularly on TT3 levels in the HT and HP models. It can therefore be assumed that NSE could be used as a supportive natural alternative source to improve thyroid hormone levels and relieve increased oxidative stress.