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3.
Turk Kardiyol Dern Ars ; 52(1): 36-43, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-38221833

RESUMO

OBJECTIVE: Early diagnosis of septic emboli is crucial to prevent the associated morbidity and mortality. This study aimed to examine the relationship between the systemic coagulation inflammation index (SCII) and septic embolism in patients with infective endocarditis (IE). METHODS: We retrospectively analyzed the data of 167 IE patients treated at our tertiary care hospital between January 2007 and January 2023. We collected information on symptoms, comorbidities, predisposing valve diseases, prosthetic valves, devices, history of injectable drug use, blood culture results, echocardiographic findings, and complications. The SCII index was calculated using the formula: [platelet count (PLT) × fibrinogen level (g/L) / white blood cell count (WBC)]. RESULTS: The mean age of the patients was 61 years, with rheumatic valve disease being the most common predisposing factor. The most common etiologic microorganism was Staphylococcus species. Septic embolism developed in 25.7% of the patients, with the cerebral system being the most commonly affected (46.5%). The SCII was identified as an independent marker for the development of septic embolism. Receiver operating characteristic (ROC) curve analysis confirmed that an optimal SCII value of 59.8 predicted septic emboli with a sensitivity of 65.1% and a specificity of 59.6% (area under the ROC curve: 0.649 [95% confidence interval (CI): 0.556 - 0.743], P = 0.004). CONCLUSION: This study demonstrates that high SCII levels are an independent predictor for the development of septic embolism in patients with IE.


Assuntos
Embolia , Endocardite Bacteriana , Endocardite , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Endocardite/complicações , Endocardite/tratamento farmacológico , Endocardite Bacteriana/terapia , Biomarcadores , Inflamação/complicações , Embolia/complicações
5.
Int J Phytoremediation ; 26(3): 416-426, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37592756

RESUMO

Dyes are frequently used in industries such as textile, leather, paper and printing, to water sources causes harmful effects on the environment and human health. Therefore, it is crucial to effectively remove colored contaminants from water in order to protect the environment and public health, maintain biodiversity and preserve the esthetic aspects of water resources. In this study, wood chips obtained from Pinus brutia (PB) tree grown in many parts of the world were turned into biochar and then modified and used for the removal of malachite green, a cationic dye. For this purpose, biochar (PBB) was made by collecting PB wood and turning it into chips (PB). Later, PBB was modified to gain nano-magnetic properties. The structure of the obtained PBB and nM-PBB adsorbents was characterized by FT-IR. pH (2-9), temperature (25 °C-55 °C), time change (15 min-240 min), adsorbent amount change (0.05 g-0.45g) and MG concentration (25 mg/L-250 mg/L) were investigated in MG removal of PBB and nM-PBB. The process was found to be pseudo-second-order and spontaneous endothermic reaction. PBB and nM-PBB were found to be suitable for Langmuir isotherm in MG removal (qmax=13.004 mg/g for PBB, qmax=18.215 mg/g for nM-PBB).


Various adsorbents are used to remove different substances from water. The use of pinus brutia tree, which is a biochar product, in the removal of malachite green dyes from aqueous solutions has not been found in the literature. The findings revealed that Pinus brutia could be used to extract malachite green, a cationic dyestuff. Pinus brutia is a widely distributed, easy-to-access, low-cost species with many uses. Our study, in which Pinus brutian is used as an adsorbent, will contribute to the literature in this respect, and its use in the removal of different anionic and cationic dyes will be discussed in the future.


Assuntos
Carvão Vegetal , Pinus , Corantes de Rosanilina , Poluentes Químicos da Água , Humanos , Corantes/química , Espectroscopia de Infravermelho com Transformada de Fourier , Poluentes Químicos da Água/química , Adsorção , Concentração de Íons de Hidrogênio , Biodegradação Ambiental , Água , Cinética , Termodinâmica
6.
Medeni Med J ; 38(4): 252-259, 2023 Dec 26.
Artigo em Inglês | MEDLINE | ID: mdl-38148713

RESUMO

Objective: Obstructive sleep apnea syndrome (OSAS) is a sleep disorder whose frequency is increasing daily due to modern lifestyle. Patients with atrial fibrillation (AF), which has the same predisposing factors, frequently visit the outpatient clinic with complaints of palpitation. Existing symptoms are often associated with the course of OSAS, and the development of AF, a disease with high morbidity and mortality, cannot be detected. In our study, we investigated the relationship between the visceral adiposity index (VAI) and AF development in these patients. Methods: We retrospectively analyzed 207 patients with OSAS who visited the cardiology outpatient clinic. The data of 44 patients with AF and 163 patients without AF were compared. Results: Demographic characteristics and clinical risk factors were similar between the groups (p>0.05). VAI, apnea-hypopnea index, and inflammatory markers were higher in the AF group, and these risk factors were significant in the multivariate analysis (p<0.05). Conclusions: Our study is important in terms of showing VAI as one of the most important predictors of AF, which has an impact on mortality and morbidity in patients with OSAS, whose frequency is increasing daily. Further prospective studies are required to confirm our observations and determine their clinical applicability.

7.
Postgrad Med ; 135(7): 669-675, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37503966

RESUMO

OBJECTIVE: Spontaneous coronary artery dissection (SCAD) is a rare but potentially life-threatening pathology and cases are especially seen in women under 50 years of age and with relatively fewer cardiovascular risk factors. Although risk factors facilitating the development of SCAD have been defined in the literature, modifiable risk factors remain unclear. In this study, it was aimed to investigate the relationship between the triglyceride glucose index (TyG) and the development of SCAD in the population of young women. METHODS: The results of 281 patients were analyzed and compared with each other in terms of clinical, demographic, laboratory parameters, and coronary angiography results. RESULTS: The mean age was 45 years and all of them were female. When the groups were compared, the TyG and inflammatory parameters were higher in the SCAD group (p < 0.001). When these two groups with low cardiovascular risk factors were compared in logistic regression analysis, high TyG was found to be an independent predictor of SCAD development in young women (p < 0.001). CONCLUSION: As a result, our study shows that the development of these non-atherosclerotic conditions can be predicted by simple biochemical tests in young women with low atherosclerotic cardiovascular risk factors.

8.
Curr Oncol ; 30(5): 4575-4585, 2023 04 28.
Artigo em Inglês | MEDLINE | ID: mdl-37232804

RESUMO

Breast cancer is the most common type of malignancy in women and radiotherapy (RT) is an important part of treatment. Although it reduces cancer recurrence, it has been shown to cause accerelerated athnerosclerosis. This study aimed to compare the results of myocardial perfusion scintigraphy (MPS) for ischemia investigation with coronary angiography (CAG) findings and to investigate the effect of RT on the development of coronary artery disease in breast cancer patients who underwent RT. The results of 660 patients were analyzed and compared with each other in terms of clinical, demographic, laboratory parameters and MPS results. The mean age was 57.5 years and all of them were female. When the groups were compared, the Gensini score and marking of the left anterior descending artery (LAD) area as ischemic area localization were found more, but angiographically, the rate of severe stenosis in the area indicated by MPS was found to be lower in the RT group (p < 0.001). While the sensitivity of MPS in the RT group was 67.5% and non-RT group was 88.5% (p < 0.001), the result of our study shows that the sensitivity of the MPS test is significantly lower in the patient group receiving RT.


Assuntos
Neoplasias da Mama , Doença da Artéria Coronariana , Humanos , Feminino , Pessoa de Meia-Idade , Masculino , Angiografia Coronária , Neoplasias da Mama/radioterapia , Recidiva Local de Neoplasia , Imagem de Perfusão
9.
Medicina (Kaunas) ; 59(3)2023 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-36984506

RESUMO

Background and Objectives: Percutaneous procedures using contrast agents are modern diagnosis and treatment methods for cardiovascular diseases. Contrast use may cause nephropathy, especially in diabetic patients. SGLT2 inhibitors have strong cardioprotective and renal protective effects. In our study, we investigated the effectiveness of this drug group in preventing the development of Contrast-Induced Nephropathy (CIN). Materials and Methods: The results of 312 diabetic patients who underwent CAG were analyzed. The study group included 104 DM patients using SGLT2 and the control group did not use SGLT2. These groups were compared with each other in terms of clinical, demographic, and laboratory parameters. Results: The groups were similar characteristics. However, post-CAG creatinine values compared with before the procedure, the development of CIN was observed to be significantly less in the group using SGLT2 inhibitor (p = 0.03). When the results of the multivariate analysis were examined, it was seen that the use of SGLT2 inhibitors significantly reduced the risk of CIN (odds ratio (OR): 0.41, 95% confidence interval (CI): 0,142-0.966, p = 0.004). Conclusions: Our study showed that SGLT2 inhibitors may be protective against the development of CIN, especially in patients with comorbid conditions such as diabetes.


Assuntos
Meios de Contraste , Diabetes Mellitus , Nefropatias , Infarto do Miocárdio sem Supradesnível do Segmento ST , Inibidores do Transportador 2 de Sódio-Glicose , Humanos , Meios de Contraste/efeitos adversos , Angiografia Coronária , Diabetes Mellitus/etiologia , Nefropatias/induzido quimicamente , Infarto do Miocárdio sem Supradesnível do Segmento ST/etiologia , Intervenção Coronária Percutânea , Fatores de Risco , Inibidores do Transportador 2 de Sódio-Glicose/uso terapêutico , Resultado do Tratamento
12.
ACG Case Rep J ; 9(3): e00752, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35359751

RESUMO

The therapeutic options in portal vein thrombosis cases of young age and low weight, as in this case, are limited. Interventional radiologists also have minimal experience in pediatric patients. There are no reported cases anywhere worldwide, especially in this age group. However, we think that balloon angioplasty can be safely applied in cases in which esophageal variceal bleeding cannot be controlled using traditional treatment.

13.
Medicina (Kaunas) ; 58(2)2022 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-35208466

RESUMO

Background and Objectives: Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (SII) and coronary thrombus burden in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography and percutaneous coronary intervention (PCI). Materials and Methods: A total of 389 patients with the diagnosis of NSTEMI participated in our study. Coronary thrombus burden was classified in the TIMI (thrombolysis in myocardial infarction) thrombus grade scale and patients were divided into two groups: a TIMI thrombus grade 0-1 group (n = 209, 157 males) and a TIMI thrombus grade 2-6 group (n = 180, 118 males). Demographics, angiographic lesion images, coronary thrombus burden, clinical risk factors, laboratory parameters, and SII score were compared between the two groups. Results: The high thrombus burden patient group had a higher neutrophil count, WBC count, platelet count, and systemic immune-inflammation index (SII) (p < 0.001). The receiver operating characteristic (ROC) curve analysis showed that at a cutoff of 1103, the value of SII manifested 74.4% sensitivity and 74.6% specificity for detecting a high coronary thrombus burden. Conclusions: Our study showed that the SII levels at hospital admission were independently associated with high coronary thrombus with NSTEMI.


Assuntos
Síndrome Coronariana Aguda , Intervenção Coronária Percutânea , Infarto do Miocárdio com Supradesnível do Segmento ST , Trombose , Síndrome Coronariana Aguda/diagnóstico , Angiografia Coronária/métodos , Humanos , Inflamação/etiologia , Masculino , Intervenção Coronária Percutânea/métodos , Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia , Trombose/etiologia , Resultado do Tratamento
16.
Monaldi Arch Chest Dis ; 92(1)2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34579518

RESUMO

In clinical practice, cardiac myxomas constitute the majority of benign cardiac neoplasms, and might potentially present with a variety of embolic, obstructive as well as constitutional symptoms. On the other hand, these neoplasms might be potentially associated with the evolution of takotsubo cardiomyopathy (TTC) that is universally considered as a transient form of acute myocardial dysfunction. Accordingly, the present paper primarily aims to focus on potential mechanisms and associated clinical implications of TTC evolution in the setting of cardiac myxomas.


Assuntos
Embolia , Neoplasias Cardíacas , Mixoma , Cardiomiopatia de Takotsubo , Embolia/complicações , Neoplasias Cardíacas/complicações , Humanos , Mixoma/complicações , Cardiomiopatia de Takotsubo/complicações
19.
Monaldi Arch Chest Dis ; 91(4)2021 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-34092074

RESUMO

In clinical practice, pathophysiology of Takotsubo syndrome (TTS) has been attributed to adrenergic discharge mostly associated with a variety of stressors. Occasionally, organic sources of adrenergic discharge (including pheochromocytoma) might also account for this phenomenon and are not considered as exclusion criteria for the diagnosis of TTS (as opposed to previous suggestions). We read with great interest the recently published article by Maffè et al. that describes a case of fatal TTS due to a ruptured pheochromocytoma in a middle-aged male. In this context, we would like to comment on this interesting case and potential implications of TTS associated with pheochromocytoma....


Assuntos
Neoplasias das Glândulas Suprarrenais , Feocromocitoma , Cardiomiopatia de Takotsubo , Neoplasias das Glândulas Suprarrenais/complicações , Neoplasias das Glândulas Suprarrenais/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Feocromocitoma/complicações , Cardiomiopatia de Takotsubo/diagnóstico , Cardiomiopatia de Takotsubo/etiologia
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