An analysis of antibody response following the second dose of CoronaVac and humoral response after booster dose with BNT162b2 or CoronaVac among healthcare workers in Turkey.

Limited data are available on the short- to midterm levels of antibodies to the CoronaVac vaccine and quantitative change in humoral response after homologous or heterologous booster doses. In this prospective cohort study, we evaluated the anti-receptor-binding domain (RBD) immunoglobulin G (IgG) levels after two doses of CoronaVac and heterologous/homologous booster administration among healthcare workers in a university hospital in Turkey. Quantitative anti-RBD IgG antibody levels were measured at first and fourth months in 560 healthcare workers who had completed two doses of CoronaVac vaccine, and within 2 months after the third dose of CoronaVac or BNT162b2. Participants were asked to complete a questionnaire during the first blood draw. The seropositivity rate was 98.9% and 89.1%, and the median antibody level was 469.2 AU/ml and 166.5 AU/ml at first and fourth month, respectively. In the fourth month, a mean reduction of 61.4% ± 20% in antibody levels was observed in 79.8% of the participants. The presence of chronic disease (odds ratio [OR]: 1.76, 95% confidence interval [CI]: 1.15-2.69) and being in the 36-50 age group (OR: 2.11, 95% CI: 1.39-3.19) were identified as independent predictors for low antibody response. The antibody level increased 104.8-fold (median: 17 609.4 vs. 168 AU/ml) and 8.7-fold (median: 1237.9 vs. 141.4 AU/ml) in the participants who received BNT162b2 and CoronaVac, respectively. During the follow-up, 25 healthcare workers (4.5%) were infected with severe acute respiratory syndrome coronavirus 2. Considering the waning immunity and circulating variants, a single booster dose of messenger RNA vaccine seems reasonable after the inactivated vaccine especially in risk groups.

A Rare Tumor of Palatine Tonsils: Chondrolipoma.

Chondrolipomas are benign mesenchymal tumors that have two mature tissues simultaneously and emerge as a result of cartilaginous metaplasia in lipomas. They rarely occur in the head and neck area (1%-4%), and occur more frequently in the 60-70 years age group. Although there are cases of the nasopharynx, tongue, lip, and neck reported in the literature, we have been able to find only two cases on tonsils. The case of a 17-year-old male patient, who presented to our clinic complaining of dysphagia and was diagnosed with tonsillar chondrolipoma, is described here, along with the radiological, clinical, and immunohistochemical findings, as well as the review of the literature.

25-gauge sutureless vitrectomy in osteogenesis imperfecta type I.

PURPOSE: To report a case with type I osteogenesis imperfecta (OI) with intravitreal opacities who underwent 25-gauge sutureless vitrectomy. METHODS: A 2.5-year-old girl with OI type I who presented with intravitreal opacities underwent 25-gauge sutureless vitrectomy. RESULTS: The 25-gauge sutureless vitrectomy system, which is less traumatic, was performed in a patient with OI type I. Nine months postoperatively, funduscopic examination under general anesthesia showed a healthy optic nerve and retina without detachment. Intraocular pressure by Tonopen was 10 mmHg. CONCLUSION: The use of 25-gauge sutureless vitrectomy to avoid scleral suturing and minimize surgical trauma is an option in pediatric patients with associated thin sclera.