RESUMO
Endemic Sideritis dichotoma Huter, herbal tea, is used for colds, coughs and digestive ailments. Since at least 25 % of the active ingredients of pharmacological drugs are obtained from plants, it is important to investigate many plants, both traditionally used and whose potential hasnt yet been discovered, before they disappear. When the results compared to other Sideritis species, it has better antioxidant activity in DPPHâ scavenging activity, Fe3+ and Cu2+ reducing capacity methods and is also rich in minerals, necessary for human body, K, Mg, Ca, P, S. Zone values (10-19,5â mm) obtained on S. aureus, P. aeruginosa, E. coli, S.enteritidis, E. faecalis, P. putida and K. pnemoniae strains are an indication that the plant has antibacterial activity. 27â secondary metabolites were identified by LC-HRMS. Verbascoside, pharmacologically active compound known to have antitumor effect, cytotoxic selectivity and anticancer activity, is the most abundant phenolic in ethanol extract (49297.13â mg/kg).
Assuntos
Antioxidantes , Sideritis , Humanos , Antibacterianos/farmacologia , Antioxidantes/análise , Escherichia coli/metabolismo , Minerais , Fenóis/farmacologia , Fenóis/análise , Compostos Fitoquímicos/farmacologia , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Sideritis/química , Staphylococcus aureus/metabolismo , Chá , Ferro/química , Cobre/químicaRESUMO
Terminalia citrina (T.â citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized water (WTE) and alcohol extracts (ETE) of T.â citrina fruits, their phenolic content by LC-HRMS, and their effects on cholinesterases (ChEs; AChE, acetylcholinesterase, and BChE, butyrylcholinesterase) were investigated. Especially ten different analytical methods were applied to determine the antioxidant capacity. Compared with similar studies for natural products in the literature, it was determined that both WTE and ETE exhibited strong antioxidant capacity. Syringe and ellagic acids were higher than other acids in ETE and WTE. IC50 values for ETE and WTE in DPPH radical and ABTSâ + scavenging activities were calculated as 1.69-1.68â µg mL-1 and 6.79-5.78â µg mL-1 , respectively. The results of the biological investigations showed that ETE and WTE had an inhibition effect against ChEs, with IC50 values of 94.87 and 130.90â mg mL-1 for AChE and 262.55 and 279.70â mg mL-1 for BChE, respectively. These findings indicate that with the prominence of herbal treatments, T.â citrina plant may guide the literature in treating Alzheimer's Disease, preventing oxidative damage, and mitochondrial dysfunction.
Assuntos
Butirilcolinesterase , Terminalia , Butirilcolinesterase/química , Antioxidantes/farmacologia , Antioxidantes/química , Acetilcolinesterase/química , Inibidores da Colinesterase/farmacologia , Inibidores da Colinesterase/química , Sequestradores de Radicais Livres/química , Extratos Vegetais/farmacologia , Extratos Vegetais/químicaRESUMO
Antioxidants have become scientifically interesting compounds due to their many benefits such as anti-aging and anti-inflammatory. Today, it is still used in many areas. In food technology, antioxidants are added to many foodstuffs in order to enrich the foods and eliminate the problems. Therefore, studies to determine the antioxidant activities of natural foods and their components are also continuing rapidly. Antioxidants have also been replaced in the encapsulation studies used for the preservation and stabilization of food components. Of course, preservation of foods is as important as their production. The latest packaging techniques for food preservation are edible films and coatings. The protective function of edible films and coatings can be improved by the addition of antioxidants. Unlike these, studies on plants and animals have been investigated in vivo in terms of how the antioxidant activity changes as a result of metabolic activities. The role of antioxidant enzymes in these studies is quite large. Many results have been found for the elimination of diseases by either in vivo or in vitro studies regarding antioxidants. Thus, the importance of antioxidants increased with the use in pharmacology, cosmetics and medicine. In this study, we tried to bring a current perspective to antioxidants played an active role in many fields by combining the technological applications and scientific studies of antioxidants. In order to further customize the issue, we have done this especially for the food and health field and we have tried to emphasize the importance of antioxidants in this way.
RESUMO
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors.