RESUMO
In the present study, some toxic effects of cisplatin are evaluated in rats. It was also investigated whether S-carboxymethylcysteine (S-CMC), a free radical scavenger, protects the experimental animals from the toxic effects of cisplatin. The 1st, 2nd, 4th and 5th groups received physiological saline, dimethyl sulphoxide, and S-CMC (100 and 500 mg/kg i.p.) for 3 days, respectively. The 3rd group received cisplatin (5 mg/kg i.p.) 12 h before sacrifice. The 6th and 7th groups received S-CMC (100 and 500 mg/kg i.p., respectively); additionally, these groups received cisplatin (5 mg/kg i.p.) 12 h before the rats were sacrificed. 5 mg/kg cisplatin decreased significantly serum creatinine and glutamic-oxaloacetic and glutamic-pyruvic transaminase levels as well as leucocyte counts. Although S-CMC did not change the effects of cisplatin on creatinine and liver enzyme levels, it eliminated the effect of cisplatin on leucocyte counts. Cisplatin increased significantly urinary creatinine level and creatinine clearance. Cisplatin caused some histological changes in kidney and liver.
Assuntos
Carbocisteína/farmacologia , Cisplatino/toxicidade , Animais , Biomarcadores/análise , Contagem de Células Sanguíneas/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Rim/efeitos dos fármacos , Rim/patologia , Fígado/efeitos dos fármacos , Fígado/patologia , Masculino , RatosRESUMO
In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed.
Assuntos
Cromossomos/efeitos dos fármacos , Ciprofloxacina/toxicidade , Rim/efeitos dos fármacos , Fígado/efeitos dos fármacos , Alanina Transaminase/sangue , Fosfatase Alcalina/sangue , Animais , Aspartato Aminotransferases/sangue , Nitrogênio da Ureia Sanguínea , Ciprofloxacina/administração & dosagem , Creatinina/sangue , Concentração de Íons de Hidrogênio , Rim/patologia , Rim/fisiologia , L-Lactato Desidrogenase/sangue , Fígado/patologia , Fígado/fisiologia , Masculino , Ratos , Urina/químicaRESUMO
The effects of ciprofloxacin were investigated on colonic microbial flora and Paneth cells in eight healthy albino rabbits following a 10 mg intravenous dose. Two rabbits were used as control group. Aerobic fecal cultures were negative on rabbits of experiment. Vacuolisation and reduction of eosinophilic fields were seen in Paneth cells by light microscopic examination.
Assuntos
Bactérias/efeitos dos fármacos , Ciprofloxacina/farmacologia , Colo/microbiologia , Animais , Ciprofloxacina/administração & dosagem , Colo/citologia , Colo/efeitos dos fármacos , Células Epiteliais , Epitélio/efeitos dos fármacos , Fezes/microbiologia , Injeções Intravenosas , CoelhosRESUMO
It is well known that infection-induced stones (apatite, struvite), uric acid and cystine calculi in the urinary tract can be managed by the use of certain chemical solutions. We investigated the effects of various acidic and alkaline solutions on the rabbit urothelium. Acidic solutions (pH: 4.2) caused more urothelial injury as compared to alkaline solutions (pH: 7.6). Ureteral injury was more severe than the bladder injury. Magnesium-containing solutions caused less injury to the urothelium.
