RESUMO
Introducción: Los pacientes diabéticos asocian depresión con una frecuencia mayor que la población general. Actualmente se considera que existe una relación bidireccional entre diabetes y depresión. Objetivo: El objetivo del estudio fue conocer la frecuencia de síntomas depresivos y su vínculo con factores sociodemográficos, control metabólico, tratamiento y complicaciones crónicas en una unidad de diabetes. Resultados: Se incluyeron 142 pacientes, la frecuencia de síntomas de depresión fue de 36.7%. Se encontró asociación con complicaciones crónicas y menor adherencia al tratamiento. Conclusiones: Es necesario utilizar métodos de screening para evaluar depresión en población de pacientes con diabetes.
Introduction: Diabetic patients associate depression with a higher frequency than the general population. It is currently considered that there is a bidirectional relationship between diabetes and depression. Objetive: The objective of the study was to determine the frequency of depressive symptoms and their relationship with sociodemographic factors, metabolic control, treatment, and chronic complications in a diabetes unit. Results: 142 patients were included, the frequency of depression symptoms was 36.7%. An association with chronic complications and lower adherence to treatment was found. Conclusions: It is necessary to use screening methods to assess depression in the population of patients with diabetes.
Introdução: Pacientes diabéticos associam a depressão com maior frequência do que a população em geral. Atualmente considera-se que existe uma relação bidirecional entre diabetes e depressão. Objetivo: O objetivo do estudo foi determinar a frequência de sintomas depressivos e sua relação com fatores sociodemográficos, controle metabólico, tratamento e complicações crônicas em uma unidade de diabetes. Resultados: 142 pacientes foram incluídos, a frequência de sintomas de depressão foi de 36,7%. Encontrou-se associação com complicações crônicas e menor adesão ao tratamento. Conclusões: É necessário usar métodos de triagem para avaliar a depressão na população de pacientes com diabetes.
RESUMO
Caldorazole (1) was isolated from the marine cyanobacterium Caldora sp. collected on Ishigaki Island, Okinawa, Japan. Its structure was determined to be a new polyketide that contained two thiazole rings and an O-methylenolpyruvamide moiety. Caldorazole (1) showed strong cytotoxicity toward tumor cells that had been seeded at a high density. Cell death induced by 1 in HeLa and A431 cells was also observed only in the presence of the glycolysis blocker 2-deoxy-d-glucose (2DG). Co-treatment with 1 and 2DG remarkably decreased ATP levels in these cells. Furthermore, 1 selectively inhibited complex I in the mitochondrial respiratory chain. Thus, 1 was demonstrated to exert cytotoxicity toward human tumor cells by blocking mitochondrial respiration.
