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1.
Braz J Otorhinolaryngol ; 90(6): 101492, 2024 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-39205364

RESUMO

OBJECTIVES: This study aims to assess the impact of the Neutrophil/Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP), both markers of systemic inflammation, on the duration of hospitalization for Deep Neck Infections (DNIs). METHODS: The research encompassed patients of all age groups admitted between January 2016 and January 2021 due to DNIs. Patient data, including demographic details, etiology, comorbidities, radiological findings, treatment specifics, laboratory results (CRP values, leukocyte counts, neutrophil counts, lymphocyte counts, NLR), culture outcomes, length of stay, complications, mortalities were retrospectively evaluated. Patients were categorized into two groups based on their hospitalization duration: less than 7-days and 7-days or more. Univariate and multivariate analyses were conducted to examine the association between age, NLR, CRP, and hospital stay length. RESULTS: The study encompassed 275 patients, with a mean age of 36 ±â€¯20.2 years. The mean hospital stay was 9.6 ±â€¯6.6 days. Tonsillopharyngeal infections were the most common etiology (34%). Notably, in both univariate and multivariate analyses, age, NLR, and CRP values demonstrated significant (p < 0.05) predictive influence on hospitalization duration. CONCLUSION: Age emerges as a determinant that affects hospital stay duration in DNIs. Moreover, NLR is proven to be comparable to CRP in predicting hospitalization length for these patients. NLR's feasibility as a cost-effective predictive marker, being conveniently derived from routine complete blood count assessments, adds to its clinical significance. This study underscores the potential value of NLR and CRP in informing patient management and care strategies for DNIs.

2.
Braz. j. otorhinolaryngol. (Impr.) ; Braz. j. otorhinolaryngol. (Impr.);87(4): 416-421, July-Aug. 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1285702

RESUMO

Abstract Introduction Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. Objectives To assess the prognostic values of metastatic lymph node number, ipsilateral/contralateral harvested lymph nodes, and lymph node ratio in patients undergoing surgical treatment of laryngeal squamous cell carcinoma. Methods Seventy-four patients diagnosed with laryngeal squamous cell carcinoma primarily managed surgically were included in this study. The patients' pathological and survival data were obtained from their medical records. The effects of harvested lymph nodes and lymph node ratio on disease-free survival, disease-specific survival, and overall survival were analyzed. Results Ipsilateral, contralateral, and bilateral evaluations of harvested lymph nodes showed no significant associations with prognosis. Lymph node ratio was significantly associated with overall survival when evaluated bilaterally. Metastatic lymph node number showed more suitable stratification than TNM classification. Conclusions Metastatic lymph node number and bilateral lymph node ratio parameters should be taken into consideration to improve the prognostic capacity of TNM.


Resumo Introdução A metástase linfonodal é um fator prognóstico bem conhecido para o carcinoma de laringe. Entretanto, os sistemas atuais de estadiamento nodal fornecem informações limitadas sobre o prognóstico. Parâmetros adicionais devem ser considerados para melhorar a capacidade prognóstica. Objetivos Avaliar os valores prognósticos do número de linfonodos metastáticos, linfonodos ipsilaterais /contralaterais coletados e relação de linfonodos em pacientes submetidos ao tratamento cirúrgico do carcinoma espinocelular da laringe. Método Foram incluídos neste estudo 75 pacientes com diagnóstico de carcinoma espinocelular da laringe, tratados primariamente por meio de cirurgia. Os dados histopatológicos e de sobrevida dos pacientes foram obtidos de seus prontuários médicos. Foram analisados os efeitos dos linfonodos coletados e da relação de linfonodos na sobrevida livre de doença, sobrevida doença-específica e sobrevida global. Resultados As avaliações ipsilateral, contralateral e bilateral dos linfonodos coletados não mostraram associações significativas com o prognóstico. A relação de linfonodos foi significantemente associada à sobrevida global quando avaliada bilateralmente. O número de linfonodos metastáticos mostrou estratificação mais adequada do que a classificação TNM-N. Conclusões Os parâmetros número de linfonodos metastáticos e relação de linfonodos bilateral devem ser levados em consideração para melhorar a capacidade prognóstica da classificação TNM.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço , Prognóstico , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço , Razão entre Linfonodos , Excisão de Linfonodo , Linfonodos/cirurgia , Linfonodos/patologia , Estadiamento de Neoplasias
3.
Braz J Otorhinolaryngol ; 87(4): 416-421, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32988784

RESUMO

INTRODUCTION: Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. OBJECTIVES: To assess the prognostic values of metastatic lymph node number, ipsilateral/contralateral harvested lymph nodes, and lymph node ratio in patients undergoing surgical treatment of laryngeal squamous cell carcinoma. METHODS: Seventy-four patients diagnosed with laryngeal squamous cell carcinoma primarily managed surgically were included in this study. The patients' pathological and survival data were obtained from their medical records. The effects of harvested lymph nodes and lymph node ratio on disease-free survival, disease-specific survival, and overall survival were analyzed. RESULTS: Ipsilateral, contralateral, and bilateral evaluations of harvested lymph nodes showed no significant associations with prognosis. Lymph node ratio was significantly associated with overall survival when evaluated bilaterally. Metastatic lymph node number showed more suitable stratification than TNM classification. CONCLUSIONS: Metastatic lymph node number and bilateral lymph node ratio parameters should be taken into consideration to improve the prognostic capacity of TNM.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Humanos , Excisão de Linfonodo , Razão entre Linfonodos , Linfonodos/patologia , Linfonodos/cirurgia , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Carcinoma de Células Escamosas de Cabeça e Pescoço
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