The relationship of serum proteins, protein-bound iodine and Tri-lodothyronine binding capacity in Filipino children with the nephrotic syndrome

These data indicate that patients with nephrotic syndrome have diminished thyroid hormone binding proteins as shown by the result that 14 of the 22 nephrotic patients have low residual or reserve binding proteins as reflected by a low T3-I13 binding capacity. Of these 14 patients with low or reduced thyroid hormone binding proteins, only 5 have actually low PBI values while the rest have normal PBI except for 2 patients with unexplained high PBI levelsWhen correlated with their serum albumin all 14 patients with diminished T3-I13 binding capacity have severe hypoalbuminemia. This confirms the observation of Musa et al that in patients with nephrotid syndrome, the serum protein binding of thyroid hormone is more closely related to the serum albumin.(Conclusion)