RESUMO
Background and Aims: Antibiotic resistance (ABR) is a global public health emergency which has seen an uptick in low- to middle-income countries in recent times due to a plethora of aggravating factors and has led to a whole host of setting-specific pathogens registering high rates of resistance, causing outbreaks with graver mortality and morbidity. This review analyzes available literature to determine the causes and effects of ABR and recommend solutions to the problem in a Pakistani setting. Methods: Sources for this narrative review were identified via electronic databases using keyword search methods. The information was retrieved using databases such as PubMed and Science Direct. Additionally, websites such as CDC and World Health Organization were used to attain pertinent information. All the sources were selected as per their relevance and appropriateness toward the purpose of this review. Results: This review details the causes by dividing them into three primary strata, namely (1) under-regulation, (2) over-prescription and self-medication, and (3) lack of medical stewardship. This is made much graver when the COVID-19 pandemic and the subsequent erratic treatment response is considered, with the pandemic augmenting already high levels of consumption. These factors have led a cascade of effects including, but not limited to, a considerable increase in ABR in pathogens to first-line drugs. Conclusion: ABR is a serious and growing issue which will result in undesirable personal, local, and national consequences if unchecked. Mitigation and reversal of this trend is necessary by developing existing programs and investing in novel therapies and pharmaceutical research and strengthening regulatory policies and mechanisms.
RESUMO
Malaria, a vector borne disease that can quickly become life-threatening, has become endemic to many countries, in particular Afghanistan. Ranking third for world's highest burden of malaria, Afghanistan has found itself in a downward spiral, burdened by outbreaks of not only malaria, but dengue, watery diarrhea and measles as well. The civil conflict and lack of healthcare services present compounded with the COVID-19 pandemic resulted in a five-to tenfold increase of malarial incidence in the past years. Increased refugee shuttling and fluctuating environmental conditions have allowed proliferation of malarial vectors, with restricted access to treatment impeding elimination of malaria as well. Although efforts like larvicides, indoor spraying and initiatives like the Sehatmandi project have been made to control the spread of malaria, further efforts focusing on more sustainable and economical preventative measures are essential. Thus, efforts on both individual and global levels, more research and maintenance of control measures, are necessary to eliminate outbreaks and risks of resurgence.
