[Metabolic bone tissue markers dynamics as criteria for periodontal disease treatment efficiency]. / Izmenenie pokazatelei metabolizma kostnoi tkani kak kriterii effektivnosti lecheniya generalizovannogo parodontita.

The purpose of the study was to investigate the evolution of the tissue metabolism parameters in the course of the treatment of aggressive periodontitis forms. MATERIALS AND METHODS: The paper presents the results of the treatment of 68 patients with chronic generalized periodontitis. The control group comprised 10 healthy individuals. The patients of groups 1 and 3 were treated with metronidazole placement into gingival pockets; those of groups 2 and 4 received a mixture of metronidazole and Eplan. General therapy of group 1 and 2 included treatment with Calcemin, while that of group 3 and 4 alendronate and alphacalcidolum based medicine. Treatment efficiency was assessed by clinical signs, alkaline phosphatase level activity in the oral fluid, as well as serum levels of general and a ionized calcium, phosphorous, alkaline phosphatase and and osteocalcin. RESULTS: The test results before treatment showed higher level of the alkaline phosphatase and osteocalcin in the blood of the patients with periodontitis vs. controls. In the course of follow up group 4 patients showed a clinical response already on the 3rd day of treatment, activization of osteogenesis and bone tissue mineralization in 3 months, and a recovery of the bone metabolism markers in 12 months after local application of Eplan and intake of alendronate and alphacalcidolum based medicine. CONCLUSION: The proposed therapy using Eplan and alendronate and alphacalcidolum based medicines increases the efficiency of periodontitis therapy, which allows for a faster relief of inflammation of periodontal tissues, bone tissue mineralization, long-term and sustainable disease regression.

Correlation of Lipid Profile and Glycated Hemoglobin as a New Prognostic Criterion for Type 2 Diabetes Mellitus Development and Progression.

The aim of the study was to assess correlations between the lipid profile and glycated hemoglobin in order to define their prognostic value as a criterion for the development and progression of type 2 diabetes mellitus (DM2) in individuals with metabolic syndrome and low body mass. MATERIALS AND METHODS: The study included the results of examining 50 patients with metabolic syndrome (group 1), 50 with low body mass index (BMI) (group 2), 50 with DM2 (group 3), and 50 apparently healthy people (control group). Biochemical indices of the lipid profile and glycated hemoglobin in the venous blood were assessed using analyzers Clima MC-15 (Spain), BS-200, and BS-200 E (China). RESULTS: It has been established that correlations of the parameters such as high-density lipoproteins (HDL), low-density lipoproteins (LDL), urea, and creatinine with BMI are expressed statistically more significantly in women in groups 1 and 2 in comparison with group 3, while in men the reverse situation is observed. Besides, correlation of triglyceride levels with BMI is statistically more marked in patients with DM2 than in apparently healthy people being positive in women and negative in men.Thus, HDL, LDL, creatinine, and urea may be diagnostically significant in the assessment of the development and progression of DM2 in men with metabolic syndrome since a strong positive correlation has been found between them and BMI, triglycerides were also found to be significant because a strong negative correlation has been detected between them and BMI.For women with metabolic syndrome, the combination of a weak correlation of BMI with the levels of HDL, LDL, urea, and creatinine and a strong positive correlation with triglycerides may be considered to be a prognostically significant index. CONCLUSION: New correlation characteristics of biochemical blood indices in DM2 may serve as prognostic criteria for disease development and progression.