RESUMO
This is a study of 2050 neonatal admissions excluding neonatal tetanus in children hospital CMC Larkana from December, 1988 to July, 1993. Six hundred and eighty-nine cases were admitted in General Paediatrics Ward before establishment of neonatal unit and 1361 cases were admitted in neonatal ward. The aime of study was to compare the disease pattern and mortality rates before and after establishment of a neonatal unit in the same hospital. Number of admissions significantly increased after the establishment of neonatal unit but there was no decline in the mortality. Changes in disease pattern were observed particularly for Gastroenteritis and miscellaneous (undetermined) category. Seventy percent of admissions were males in Ist week of their life. Commonest cause of admission and mortality was birth anoxia.
Assuntos
Unidades Hospitalares/estatística & dados numéricos , Doenças do Recém-Nascido/epidemiologia , Asfixia Neonatal/epidemiologia , Feminino , Gastroenterite/epidemiologia , Hospitais Pediátricos/estatística & dados numéricos , Humanos , Hipóxia/epidemiologia , Hipóxia/mortalidade , Recém-Nascido de Baixo Peso , Recém-Nascido , Doenças do Recém-Nascido/mortalidade , Recém-Nascido Prematuro , Masculino , Paquistão/epidemiologia , Admissão do Paciente/estatística & dados numéricos , Estudos Retrospectivos , Sepse/epidemiologia , Sepse/mortalidade , Fatores SexuaisRESUMO
The fatty acid compositions of the major cerebral cortex phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were measured in 16 term and one preterm 'cot death' infants fed exclusively either breast milk or one of two formulas. Docosahexaenoic acid (DHA; C22:6n-3) content in cerebral cortex phosphatidylethanolamine and phosphatidylserine of breast fed infants was greater than in both formula groups with significances varying between p < 0.1 and p < 0.001. Compensation for this deficiency in DHA in the formula fed infants was largely achieved by increased incorporation of docosapentaenoic acid (C22:5n-6) in the cerebral cortex of term infants and Mead (C20:3n-9) and dihomo Mead acids (C22:3n-9) in the preterm infant. As the phospholipids most affected are known to perform an important role in membrane function and are possibly integral to neurotransmission it is recommended that breast milk substitute infant formulas should contain n-3 and n-6 series polyunsaturated fatty acids in proportions similar to those of human milk.
