RESUMO
Spinal cord injury (SCI) is a devastating neurological disorder that has a substantial detrimental impact on a person's quality of life. The estimated global incidence of SCI is 40 to 80 cases per million people and around 90% of cases are traumatic. Various etiologies can be recognized for SCI, and post-traumatic SCI represents the most common of these. Patients worldwide with SCI suffer from a persistent loss of motor and sensory function, which affects every aspect of their personal and social lives. Given the lack of effective treatments, many efforts have been made to seek a cure for this condition. In recent years, thanks to their ability to regenerate tissue and repair lost or damaged cells, much attention has been directed toward the use of stem cells (embryonic, induced pluripotent, mesenchymal, hematopoietic), aimed at restoring the functional integrity of the damaged spinal cord and improving a functional recovery including sensory and motor function. In this paper, we offer an overview of the benefits and drawbacks of stem cell therapy for SCI based on clinical evidence. This report also addresses the characteristics of various stem cell treatments, as well as the field's likely future. Each cell type targets specific pathological characteristics associated with SCI and demonstrates therapeutic effects via cell replacement, nutritional support, scaffolds, and immunomodulation pathways. SCI accompanied by complex pathological processes cannot be resolved by single treatment measures. Stem cells are associated with the adjustment of the expression of neurotrophic factors that help to achieve better nutrition to damaged tissue. Single-cell treatments have been shown in some studies to provide very minor benefits for SCI in multiple preclinical studies and a growing number of clinical trials. However, SCI damage is complex, and many studies are increasingly recognizing a combination approach such as physical therapy, electrical stimulation, or medication therapy to treatment.
RESUMO
Climate change's effect on sea surface temperature (SST) at the regional scale vary due to driving forces that include potential changes in ocean circulation and internal climate variability, ice cover, thermal stability, and ocean mixing layer depth. For a better understanding of future effects, it is important to analyze historical changes in SST at regional scales and test prediction techniques. In this study, the variation in SST across the Persian Gulf and Gulf of Oman (PG&GO) during the past four decades was analyzed and predicted to the end of 21st century using a proper orthogonal decomposition (POD) model. As input, daily optimum interpolation SST anomaly (DOISSTA) data, available from the National Oceanic and Atmospheric Administration of the United States, were used. Descriptive analyses and POD results demonstrated a gradually increasing trend in DOISSTA in the PG&GO over the past four decades. The spatial distribution of DOISSTA indicated: (1) that shallow parts of the Persian Gulf have experienced minimum and maximum values of DOISSTA and (2) high variability in DOISSTA in shallow parts of the Persian Gulf, including some parts of southern and northwestern coasts. Prediction of future SST using the POD model revealed the highest warming during summer in the entire PG&GO by 2100 and the lowest warming during fall and winter in the Persian Gulf and Gulf of Oman, respectively. The model indicated that monthly SST in the Persian Gulf may increase by up to 4.3 °C in August by the turn of the century. Similarly, mean annual changes in SST across the PG&GO may increase by about 2.2 °C by 2100.
