Analyzing the impact of pulsatile flow on drug release from a single strut of a drug-eluting stent.

In this study, in-vitro experiments were performed to investigate the drug release from a single strut of a drug-eluting stent with respect to the systolic-diastolic flow and the continuous flow. Regarding, a test bench comprising a single strut and agarose gel as an arterial wall model was designed. The model chosen represents a large-scaled strut of a stent, to limit the effect of the geometrical shape of the stents on the drug release results. The comparison is carried out between two continuous flow rates and a systolic-diastolic flow pattern varying between these two flow rates, with a frequency of 70 beats per minute. The stent model is a polylactic-co-glycolic acid film (50:50) loaded with 10 % diclofenac sodium. A compartment of agarose gel (1 %) and a phosphate-buffered saline solution at 37 °C are employed to mimic the arterial wall and the blood, respectively. Our results show the importance of flow type on the drug release from the stent and distribution of drug in the hydrogel, such that the pulsatility promotes an increase in the quantity of drug absorbed into the hydrogel.

An overview of filtration efficiency through the masks: Mechanisms of the aerosols penetration.

The masks have always been mentioned as an effective tool against environmental threats. They are considered as protective equipment to preserve the respiratory system against the non-desirable air droplets and aerosols such as the viral or pollution particles. The aerosols can be pollution existence in the air, or the infectious airborne viruses initiated from the sneezing, coughing of the infected people. The filtration efficiency of the different masks against these aerosols are not the same, as the particles have different sizes, shapes, and properties. Therefore, the challenge is to fabricate the filtration masks with higher efficiency to decrease the penetration percentage at the nastiest conditions. To achieve this concept, knowledge about the mechanisms of the penetration of the aerosols through the masks at different effective environmental conditions is necessary. In this paper, the literature about the different kinds of face masks and respiratory masks, common cases of their application, and the advantages and disadvantages of them in this regard have been reviewed. Moreover, the related mechanisms of the penetration of the aerosols through the masks are discussed. The environmental conditions affecting the penetration as well as the quality of the fabrication are studied. Finally, special attention was given to the numerical simulation related to the different existing mechanisms.