RESUMO
In the version of this article initially published, the affiliation of Dr. Sandra Geurts reads "Sandra Geurts, an epidemiologist at Radbound University in Nijmegen." Radbound University is her previous affiliation, and the sentence should have been, "Sandra Geurts, an epidemiologist at Maastricht University Medical Center+ in the Netherlands."
Assuntos
Metástase Neoplásica , Neoplasias/patologia , Sistema de Registros , Neoplasias Ósseas/secundário , Neoplasias Encefálicas/secundário , Coleta de Dados , Bases de Dados Factuais , Humanos , Neoplasias Hepáticas/secundário , Estudos Longitudinais , Neoplasias Pulmonares/secundário , Linfonodos/patologia , Masculino , Estadiamento de Neoplasias , Neoplasias da Próstata/patologia , Programa de SEER , Telefac-SímileRESUMO
Experiments investigating the adsorption and desorption of cytochrome c onto and from liposomes containing 50â¯mol% 1,2-diacylphosphatidylglycerol lipids [10:0, 12:0, 14:0, 16:0, 18:1(Δ9 cis)] with 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) in pHâ¯7.4 buffered solutions of low to moderate ionic strength are reported. Fluorescence experiments show that cytochrome c has a similar adsorption affinity for the five labeled 50â¯mol% PG liposome systems investigated. Fluorescence recovery experiments reveal the extent of cytochrome c desorption upon the addition of >10× excess of unlabeled 100% 1,2-dioleoyl-sn-glycero-3-phosphatidylglycerol (DOPG) liposomes is dependent on the lipid's acyl chain length. The extent of desorption is also shown to be independent of temperature, albeit over a narrow range. The differences in the extent of cytochrome c desorption from liposomes containing PG lipids with different acyl chain lengths is attributed to the varying contribution of the binding motif involving the extended lipid anchorage in response to lipid packing stress.
Assuntos
Citocromos c/metabolismo , Glicosilfosfatidilinositóis/metabolismo , Lipossomos/química , Lipossomos/metabolismo , Lipídeos de Membrana/análise , Fosfatidilgliceróis/metabolismo , Adsorção , Citocromos c/química , Diglicerídeos/química , Diglicerídeos/metabolismo , Glicosilfosfatidilinositóis/química , Lipídeos de Membrana/química , Lipídeos de Membrana/metabolismo , Modelos Moleculares , Conformação Molecular , Simulação de Acoplamento Molecular , Concentração Osmolar , Fosfatidilcolinas/química , Fosfatidilcolinas/metabolismo , Fosfatidilgliceróis/químicaRESUMO
This article presents a brief review and summarizes current therapies for the treatment of chronic obstructive pulmonary disease, major depression, and rheumatoid arthritis. One new pharmaceutical agent is highlighted for each of the topics.
