RESUMO
A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural source for the first time. Structure elucidation of these compounds based on spectroscopicevidences. The pyran derivative was found to be a tyrosinase inhibitor more potent than kojic acid.
Assuntos
Aldeídos/isolamento & purificação , Aldeídos/uso terapêutico , Crinum/química , Inibidores Enzimáticos/isolamento & purificação , Inibidores Enzimáticos/uso terapêutico , Hiperpigmentação/tratamento farmacológico , Monofenol Mono-Oxigenase/antagonistas & inibidores , Piranos/isolamento & purificação , Piranos/uso terapêutico , Agaricus/enzimologia , Levodopa/metabolismo , Espectroscopia de Ressonância Magnética , Melaninas/biossíntese , Raízes de Plantas/química , Pironas/farmacologia , Espectrometria de Massas por Ionização por Electrospray , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
Assuntos
Beauveria/metabolismo , Sesquiterpenos/análise , Fermentação , Radical Hidroxila/metabolismo , Espectroscopia de Ressonância Magnética , Conformação Molecular , Sesquiterpenos/metabolismo , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
Phytochemical analyses of Geigeria alata (Benth. & Hook.) and Francoeuria crispa (Forssk., Cas.) (Asteraceae) essential oils were performed. G. alata oil showed moderate in vitro cytotoxicity (IC50, micrograms/ml against tumor cells; P388: 2.0, A-549: 2.5 and HT-29: 5.0), and also showed weak anti-HIV activity. S-Carvotanacetone, the major component of F. crispa oil (93.0%), was isolated and its structure was elucidated by 2D-NMR analysis.
Assuntos
Fármacos Anti-HIV/isolamento & purificação , Antineoplásicos Fitogênicos/isolamento & purificação , HIV/fisiologia , Óleos Voláteis/análise , Plantas Medicinais , Plantas Tóxicas , Animais , Fármacos Anti-HIV/química , Fármacos Anti-HIV/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/toxicidade , Sobrevivência Celular/efeitos dos fármacos , Cromatografia Gasosa-Espectrometria de Massas , HIV/efeitos dos fármacos , Humanos , Leucemia P388 , Camundongos , Células Tumorais Cultivadas , Replicação Viral/efeitos dos fármacosRESUMO
Eighteen dammarane-type triterpenes were obtained from the whole plant of Cleome africana by means of cytotoxic bioassay-directed fractionation. Twelve of them were novel compounds whose structures were elucidated by various spectroscopic methods.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Sobrevivência Celular/efeitos dos fármacos , Plantas Medicinais , Triterpenos/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/toxicidade , Região do Caribe , Leucemia P388 , Medicina Tradicional , Camundongos , Estrutura Molecular , Triterpenos/química , Triterpenos/toxicidade , Células Tumorais CultivadasRESUMO
A new lupin alkaloid, (+)-sparteine N-16-oxide was isolated from Lygos raetam var. sarcocarpa, together with five known alkaloids: (+)-aphylline, (+)-17 oxosparteine, (-)-5,6-dehydrolupanine, (-)-N-formyl cytisine and (+)-ammodenderine. The structure of the new alkaloid including absolute configuration was determined by spectroscopic methods and chemical transformation.
Assuntos
Alcaloides/química , Óxidos N-Cíclicos/química , Extratos Vegetais , Esparteína/análogos & derivados , Alcaloides/isolamento & purificação , Óxidos N-Cíclicos/isolamento & purificação , Clima Desértico , Egito , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Esparteína/química , Esparteína/isolamento & purificaçãoRESUMO
Quinolizidine and dipiperidyl alkaloids profiles have been determined for various plant organs of Lygos raetam Forssk. L. raetam var. sarcocarpa and L. raetam var. bovei, using TLC, GC, GC-MS and HPLC techniques. Sixteen quinolizidine and dipiperidyl alkaloids were identified including baptofoline alkaloid which have not previously been reported in the genus Lygos. Biological evaluulation including hypoglycemic effect, anti-inflammatory activity, and some pharmacological studies of the different extracts as well as some of the isolated alkaloids were also performed. N-methylcytisine was proved to have a significant hypoglycemic effect on the induced diabetic mice and anti-inflammatory effect against the induced odema as well as a sedation effect on locomotor activity enhanced by methamphetamine.