RESUMO
Amino pyrazole belongs to anti-inflammatory class, and is characterized by a low solubility in water. (In order to increase its solubility in water, inclusion complex of amino pyrazole with ß-CD was obtained.) The inclusion complex obtained between AMP and ß-cyclodextrin, was characterized by FT-IR, (1)H NMR, (1)H-(1)H NOESY, (13)C NMR, DEPT, XHCOR, spectra, through TG analysis, DTA, DSC and Scanning Electron Microscopy (SEM). The stoichiometry of inclusion complex is 1:1 (guest-host) and K stability is 1.1 × 10(4)M(-1).
Assuntos
Pirazóis/química , beta-Ciclodextrinas/química , Técnicas de Química Sintética , Cristalografia , Espectroscopia de Ressonância Magnética/métodos , Microscopia Eletrônica de Varredura , Solubilidade , Espectrofotometria Ultravioleta , Espectroscopia de Infravermelho com Transformada de Fourier , Eletricidade Estática , Termogravimetria , Difração de Raios X , beta-Ciclodextrinas/síntese químicaRESUMO
[1,2a]Benzimidazol-2-yl amidine was synthesized by adding cyclopentanamine to iminoester in ethanol. The structure of amidine 1 was characterized by IR, 1H NMR, 1H-1H NOESY, 13C NMR, DEPT, XHCOR spectra, thermogravimetric analysis (TGA), differential thermal analysis (DTA), differential scanning calorimetry thermograms (DSC), elementary analysis as well as by X-ray diffraction. The single crystals suitable for X-ray measurement were obtained by recrystallization at room temperature. The amidine group of a model was found to have Z configuration in the crystal. This compound crystallizes in a P2(1)/n monoclinic unit cell with parameters a=12.679(2) Å, b=8.468(3) Å, c=13.108(2) Å, ß=96.538(2)°, V=1398.2 Å3 and Z=4.
Assuntos
Amidinas/síntese química , Benzimidazóis/química , Varredura Diferencial de Calorimetria , Cristalização , Cristalografia por Raios X , Análise Diferencial Térmica , Espectroscopia de Ressonância Magnética , Modelos Moleculares , Espectrofotometria Infravermelho , Difração de Raios XRESUMO
Formation of inclusion complex between benzidine diammonium dipicrate and beta-cyclodextrin with stoichiometry 1:2 (guest-host) has been established by UV, (1)H NMR, (13)C NMR, IR spectra and powder X-ray diffractometry. (1)H NMR studies are used to confirm the inclusion and to provide information on the geometry of dipicrate inside the cavity of beta-cyclodextrin.
