Olfactory Drug Aerosol Delivery with Acoustic Radiation.

Nose-to-brain (N2B) drug delivery is a new approach to neurological disorder therapy as medications can bypass the blood-brain barrier and directly enter the brain. However, the delivery efficiency to the olfactory region using the conventional delivery method is impractically low because of the region's secluded position in a convoluted nasal cavity. In this study, the acoustic radiation force was explored as an N2B delivery alternative in a wide frequency range of 10-100,000 Hz at an increment of 50 Hz. Numerical simulations of the particle deposition in the olfactory region of four nasal configurations were performed using COMSOL. Frequency analysis of the nasal cavities revealed that eigenfrequencies were often associated with a specific region with narrow passages and some eigenfrequencies exhibited an amendable pressure field to the olfactory region. Transient particle tracking was conducted with an acoustic inlet at 1 Pa, and a frequency spectrum of 10-100,000 Hz was imposed on the airflow, which carried the particles with acoustic radiation forces. It was observed that by increasing the pulsating wave frequency at the nostrils, the olfactory delivery efficiency reached a maximum in the range 11-15 kHz and decreased after that. The correlation of the olfactory delivery efficiency and instantaneous values of other parameters such as acoustic velocity and pressure in the frequency domain was examined.

Modeling and analysis of biomagnetic blood Carreau fluid flow through a stenosis artery with magnetic heat transfer: A transient study.

We present a numerical investigation of tapered arteries that addresses the transient simulation of non-Newtonian bio-magnetic fluid dynamics (BFD) of blood through a stenosis artery in the presence of a transverse magnetic field. The current model is consistent with ferro-hydrodynamic (FHD) and magneto-hydrodynamic (MHD) principles. In the present work, blood in small arteries is analyzed using the Carreau-Yasuda model. The arterial wall is assumed to be fixed with cosine geometry for the stenosis. A parametric study was conducted to reveal the effects of the stenosis intensity and the Hartman number on a wide range of flow parameters, such as the flow velocity, temperature, and wall shear stress. Current findings are in a good agreement with recent findings in previous research studies. The results show that wall temperature control can keep the blood in its ideal blood temperature range (below 40°C) and that a severe pressure drop occurs for blockages of more than 60 percent. Additionally, with an increase in the Ha number, a velocity drop in the blood vessel is experienced.

Optimal Design of Nanoparticle Enhanced Phan-Thien-Tanner Flow of a Viscoelastic Fluid in a Microchannel.

The excellent thermal characteristics of nanoparticles have increased their application in the field of heat transfer. In this paper, a thermophysical and geometrical parameter study is performed to minimize the total entropy generation of the viscoelastic flow of nanofluid. Entropy generation with respect to volume fraction (<0.04), the Reynolds number (20,000-100,000), and the diameter of the microchannel (20-20,000 µm) with the circular cross-section under constant flux are calculated. As is shown, most of the entropy generation owes to heat transfer and by increasing the diameter of the channel, the Bejan number increases. The contribution of heat entropy generation in the microchannel is very poor and the major influence of entropy generation is attributable to friction. The maximum quantity of in-channel entropy generation happens in nanofluids with TiO2, CuO, Cu, and Ag nanoparticles, in turn, despite the fact in the microchannel this behavior is inverted, the minimum entropy generation occurs in nanofluids with CuO, Cu, Ag, and TiO2 nanoparticles, in turn. In the channel and microchannel for all nanofluids except water-TiO2, increasing the volume fraction of nanoparticles decreases entropy generation. In the channel and microchannel the total entropy generation increases by augmentation the Reynolds number.