Profile of multidrug-resistant clinical bacterial isolates at the National Hospital of Zinder (NHZ), Niger Republic in 2021

Background: Today, bacterial resistance is a public health challenge throughout the world, and infections caused by resistant bacteria are associated with increased morbidity, mortality and health care costs. The objective of this descriptive study is to determine the prevalence and distribution of multi-drug resistant (MDR) clinical bacteria isolates at the National Hospital of Zinder, Niger Republic in 2021. Methodology: We conducted a descriptive cross-sectional study of in- and out-patients from whose clinical samples' bacteria were isolated at the bacteriology unit of the laboratory. Bacteria were isolated from the clinical samples following standard aerobic cultures and identified using conventional biochemical test schemes. Antibiotic susceptibility testing (AST) was performed by the agar disk diffusion technique, and categorization of the isolates into sensitive, intermediate or resistant was done according to the recommendations of the Antibiogram Committee of the French Society of Microbiology (CA-SFM) 2020 version 1.2. MDR was defined as resistance to at least one antibiotic in three or more categories, while selected MDR bacteria such as ESBL was identified using double disk synergy test, and MRSA by cefoxitin disk diffusion test. Results: Seventy-seven (6.7%) bacterial species were isolated from 1153 clinical samples processed at the bacteriology unit of the hospital laboratory between June and December 2021, of which 65.0% (50/77) were members of the order Enterobacteriales. Escherichia coli represented 40.3% (40/77) of the isolated bacteria, Staphylococcus aureus 13.0% (10/77) and Pseudomonas aeruginosa 11.7% (9/77). The overall prevalence of MDR was 44.2% (34/77), including 61.8% (21/34) ESBL-producing Enterobacteriales (ESBL-E), 26.5% (9/34) multi-resistant P. aeruginosa and 11.7% (4/34) MRSA, with 67.6% (23/34) of the MDR isolates from outpatients. Resistance rates of the Enterobacteriales to ciprofloxacin, gentamicin, amikacin and imipenem were 62.0%, 52.0%, 38.0% and 8.0% respectively. Resistance rates of P. aeruginosa were 100.0%, 88.9%, 77.8%, 33.3%, 22.2%, and 22.2% respectively to ceftazidime, ticarcillin, imipenem, ciprofloxacin, levofloxacin, and amikacin. Resistance rates of S. aureus were 100.0%, 50.0%, 40.0%, 10.0%, 0% and 0% to penicillin G,erythromycin, cefoxitin, tetracycline, fusidic acid, and chloramphenicol respectively. ESBL-E were 47.6%,85.7% and 0% resistant to amikacin, ciprofloxacin and imipenem, and MRSA resistance rates were 75.0%, 75.0%, 50.0% and 0% to erythromycin, tetracycline, gentamicin, and chloramphenicol respectively. Conclusion: This study reports high prevalence of MDR bacteria, mainly ESBL-E, with concerning high resistance to carbapenem. Rational use of antibiotics and implementation of surveillance system for MDR bacteria must be implemented in order to limit the emergence and spread of MDR bacteria in Niger Republic.

[Penetrating neck and facialinjury : arrow, an rare but still current etiology]. / Plaie cervico faciale : la fleche , une etiologie tres rare, encore d'actualite.

Penetrating neck and facial injuries are rare withonly a few cases reported in literature. Indeed, they are extremely rare in developed countries but remain relevant in our rural areas that are characterized by the recurrence of intertribal clashes. It was in thiscontextthatwereceivedtwo patients in the department of ENT of Niamey National Hospital. They presented with head and neck trauma. The middle stage of the neck in the first case and, in the left lateral face of the nasal pyramid in the second. Surgical management, under general anesthesia, enabled the removal of an arrow in both cases.

Les plaies pénétrantes cervico-faciales par flèche ont fait l'objet de très peu de publications dans la littérature. En effet, elles sont d'une extrême rareté dans les pays développés mais restent encore d'actualité dans nos régions à communautés majoritairement rurales, caractérisées par la récurrence des affrontements intertribaux. C'est dans un tel contexte que nous avons reçu deux patients au service d'ORL et CCF de l'hôpital national de Niamey. Ils présentaient un traumatisme cervico facial. L'agent vulnérant, une tige métallique, était enfoncé dans l'étage moyen du cou chez le premier et, dans la face latérale gauche de la pyramide nasale chez le second. Une prise en charge chirurgicale, sous anesthésie générale, a permis l'extraction d'une flèche dans les deux cas.