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J Mol Graph Model ; 125: 108605, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37660616

RESUMO

In this project, the possibility of drug delivery application of three anti-Multiple sclerosis (MS) agents (containing diroximel fumarate (DXF), dimethyl fumarate (DMF), and mono methyl fumarate (MMF)) by using some heteroatom decorated graphitic carbonitride (g-C3N4) (as nano-sized carriers) have been systematically investigated. The results of the study have indicated that As-g-C3N4 QD is not a suitable candidate for drug delivery (at least in the cases of DMF, and DXF drugs); while, it would be an accurate semiconductor sensor for selective detection of each mentioned agents. Also, the use of the P-doped as well as pristine g-C3N4 QD could lead to weak electronic signals with relatively same values (in electronvolts). It means that P-g-C3N4, and g-C3N4 QDs are not good sensors for detection of each of the three considered drugs. However, those two sorbents would be suitable carriers for delivering of all three mentioned pharmaceuticals.


Assuntos
Grafite , Esclerose Múltipla , Humanos , Esclerose , Probabilidade , Fumarato de Dimetilo , Sistemas de Liberação de Medicamentos , Esclerose Múltipla/tratamento farmacológico
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