[The efficacy of membrane-stabilizing therapy in bronchial asthma]. / Effektivnost' membranostabiliziruiushchei terapii pri bronkhial'noi astme.

Lipid peroxidation was studied in 65 bronchial asthma patients aged 23-56 in aggravation of their disease and after differential therapy. Conventional treatment proved unable to correct either enhanced lipid peroxidation (LPO) or weak antioxidant defense (AOD), whereas the addition to the treatment program of membrano-stabilizers (actovegin, lipostabil) contributed to LPO and AOD normalization, improved bronchial patency and, eventually, produced early remission.

[Effect of the syndrome of asthma of effort on work fitness of bronchial asthma patients]. / O vliianii sindroma astmy fizicheskogo usiliia na trudosposobnost' bol'nykh bronkhial'noi astmoi.

A total of 133 patients aged 35 to 55 years with bronchial asthma (BA) were examined. Of these 85 patients showed an infection-dependent and 48 a steroid-dependent clinico-pathogenetic disease pattern. Physical performance was studied with regard to the character of occupation, the degree of respiratory function impairment and the effects of intal and orciprenaline sulfate on the reproducibility of asthma of effort (AE) and performance of that category of patients. The development of AE was found to lead to a further decrease of work fitness of BA patients irrespective of the clinico-pathogenetic disease pattern, the degree of external respiratory function impairment and the character of occupation, resulting in the limitation of physical work possibilities of BA patients. The data are also presented concerning the effects produced by intal and orciprenaline sulfate on AE reproducibility and work fitness of this group of patients and on the relationship between tracheobronchial hyper-reactivity and physical stimulus in the development of AE. Intal action was more pronounced as compared to orciprenaline sulfate. The data thus obtained can promote the improvement of the activity of the medical expert commission for evaluation of working capacity as well as of the standards of work recommendations in BA patients.

[Functional shifts in the respiratory and circulatory systems of bronchial asthma patients during exertion]. / Funktsional'nye sdvigi so storony organov dykhaniia i krovoobrashcheniia u bol'nykh bronkhial'noi astmoi pri fizicheskoi nagruzke.

A total of 56 patients aged 40-59 were examined for bronchial asthma of infectious-allergic etiology and moderate severity. Exercise-related bronchospasm (EB) was detected in 46 of them. Exercise tolerance was studied using bicycle ergometry, ventilometric changes with threshold exercise test and central hemodynamics was assessed in response to standard exercise with chest tetrapolar rheography. BE was associated with an additional decrease in the working capacity of patients with bronchial asthma with moderately expressed ventilation disturbances at rest. These patients were also demonstrated to have hypoergic-nature response of central hemodynamics to a standard motor test. BE-free patients with the same degree of ventilation disturbances exhibited the response close to normoergic. The evidence suggests the involvement of the hemodynamic mechanisms in the formation of an exercise tolerance threshold in bronchial asthma complicated by BE.