A new electrocardiographic criterion to differentiate between Takotsubo cardiomyopathy and anterior wall ST-segment elevation acute myocardial infarction.

Several studies have examined the ability of electrocardiography to differentiate between takotsubo cardiomyopathy (TC) and anterior wall acute ST-segment elevation myocardial infarction (AA-STEMI). In those studies, the magnitude of ST-segment elevation was not measured at the J point. The American Heart Association, American College of Cardiology Foundation, and Heart Rhythm Society guidelines recommend that the magnitude of ST-segment elevation should be measured at the J point. Accordingly, the aim of this study was to retrospectively examine whether electrocardiography, using the magnitude of ST-segment elevation measured at the J point, could differentiate 62 patients with TC from 280 with AA-STEMI. Patients with AA-STEMI were divided into following subgroups: 140 with left anterior descending coronary artery occlusions proximal to the first diagonal branch (AA-STEMI-P), 120 with left anterior descending occlusions distal to the first diagonal branch and proximal to the second diagonal branch (AA-STEMI-M), and 20 with left anterior descending occlusions distal to the second diagonal branch (AA-STEMI-D). TC had a much lower prevalence of ST-segment elevation ≥1 mm in lead V(1) (19.4%) compared to AA-STEMI (80.4%, p <0.01), AA-STEMI-P (80.7%, p <0.01), AA-STEMI-M (80%, p <0.01), and AA-STEMI-D (80%, p <0.01). ST-segment elevation ≥1 mm in ≥1 of leads V(3) to V(5) without ST-segment elevation ≥1 mm in lead V(1) identified TC with sensitivity of 74.2% and specificity of 80.6%. Furthermore, this criterion could differentiate TC from each AA-STEMI subgroup, with similar diagnostic values. In conclusion, using the magnitude of ST-segment elevation measured at the J point, a new electrocardiographic criterion is proposed with an acceptable ability to differentiate TC from AA-STEMI.

Significance of a prominent Q wave in lead negative aVR (-aVR) in acute anterior myocardial infarction.

PURPOSE: The aim of this study was to clarify the significance of a Q wave in lead negative aVR (-aVR) in anterior wall acute myocardial infarction (AMI). METHODS: Eighty-seven patients with a first anterior wall AMI were classified into 2 groups according to the presence (n = 17, group A) or absence (n = 70, group B) of a prominent Q wave (duration > or =20 milliseconds) in lead -aVR at predischarge. Group A had a higher prevalence of a long left anterior descending coronary artery (LAD), a lower left ventricular ejection fraction, and more reduced regional wall motion in the apical and inferior regions than group B. None of group A patients had an LAD that did not reach the apex. CONCLUSION: A prominent Q wave in lead -aVR in anterior wall AMI is related to severe regional wall motion abnormality in the apical and inferior regions, with an LAD wrapping around the apex.

Prolonged cardiogenic shock caused by a high-dose intravenous administration of dopamine in a patient with takotsubo cardiomyopathy.

We report a patient with takotsubo cardiomyopathy in whom cardiogenic shock continued with a high intraventricular pressure gradient (IVPG) under a high-dose intravenous administration of dopamine and in whom cessation of the administration improved the hemodynamics dramatically. The present case report suggests that the administration of dopamine may lead to further hemodynamic deterioration in patients with takotsubo cardiomyopathy who exhibits an IVPG.

Electrocardiographic differentiation between occlusion of the first diagonal branch and occlusion of the left anterior descending coronary artery.

PURPOSE: We sought to electrocardiographically distinguish ST-segment elevation (STE)-acute myocardial infarction (AMI) caused by occlusion of the first diagonal branch (D1) from STE-AMI caused by occlusion of the left anterior descending coronary artery (LAD). METHODS: We examined 28 patients with STE-AMI caused by D1 occlusion (G-D) and 342 with STE-AMI caused by LAD occlusion (G-L). RESULTS: G-D had a higher prevalence of STE > or = 0.5 mm in each of leads I and aVL and a lower prevalence of STE > or = 1 mm in each of leads V(1) through V(6) than G-L. The prevalence of STE > or = 0.5 mm in lead aVL without STE > or = 1 mm in lead V(1) was higher in G-D (82.1%) than in G-L (9.4%, P < .01). CONCLUSION: ST-segment elevation > or = 0.5 mm in lead aVL without STE > or = 1 mm in lead V(1) may be useful to distinguish STE-AMI caused by occlusion of the D1 from STE-AMI caused by occlusion of the LAD.

Determinants of ST-segment level in lead aVR in anterior wall acute myocardial infarction with ST-segment elevation.

BACKGROUND: This study aimed to clarify the determinants of ST-segment level in lead aVR in anterior wall acute myocardial infarction (AAMI). METHODS: We analyzed ST-segment levels in all 12 leads on admission and emergency coronary angiographic findings in 261 patients with a first AAMI with ST-segment elevation. The length of the left anterior descending coronary artery (LAD) was classified as follows: short = not reaching the apex; medium = perfusing less than 25% of the inferior wall; long = perfusing 25% or more of the inferior wall. RESULTS: The ST-segment level in lead aVR correlated significantly with the ST-segment levels in leads I, II, III, aVF, V(1), and V(3-6), especially with those in leads II and V(6) (r = -0.63, P < .001; r = -0.61, P < .001; respectively). Patients with a proximal LAD occlusion had a greater ST-segment level in lead aVR than those with a distal LAD occlusion (P < .001). Patients with a long LAD had a lower ST-segment level than those with a short or medium LAD (P < .05). CONCLUSIONS: The ST-segment levels, especially in leads II and V(6), the site of the LAD occlusion, and the length of the LAD affect the ST-segment level in lead aVR in ST-segment elevation AAMI.

Prolonged sinus node dysfunction caused by obstruction of the sinus node artery occurring during coronary stenting.

We report a unique case with prolonged sinus node dysfunction caused by accidental occlusion of the sinus node artery occurring during coronary stenting for a proximal right coronary lesion.

A report of 2 cases of transient mid-ventricular ballooning.

Takotsubo cardiomyopathy is now well recognized not only in Japan but also in Western countries. In the present case report, we describe 2 cases of a variant type of Takotsubo cardiomyopathy showing transient ballooning of the mid-portion of the left ventricle.

Circadian variation in symptomatic subacute stent thrombosis after bare metal coronary stent implantation.

The present study examined whether onset of symptomatic subacute stent thrombosis (SAT) varies in a circadian manner after bare metal coronary stent implantation. Among 2,305 patients who underwent bare metal coronary stent implantation, 21 (0.9%) developed symptomatic SAT. Results of the present study indicate that onset of symptomatic SAT is more frequent between 6:00 A.M. and 12:00 P.M. than at any other measured 6-hour period during the day.

Relationship between heart rate variability and left ventricular remodeling after reperfused first anterior wall acute myocardial infarction.

The aim of the present study was to test the hypothesis that inadequate improvement in heart rate variability (HRV) in the healing stage of acute myocardial infarction (AMI) is associated with left ventricular (LV) remodeling. The study group comprised 20 patients (14 men, 6 women; mean age, 61+/-12 years) with a reperfused first anterior AMI (

Effect of preinfarction angina on heart rate variability in the early phase of the first anterior wall acute myocardial infarction.

The aim of this study was to clarify the effect of preinfarction angina on heart rate variability (HRV) in anterior wall acute myocardial infarction (AMI). A total of 36 patients experiencing their first anterior wall AMI were prospectively examined. The patients were divided into 2 groups according to the presence (group A, n=24) or absence (group B, n = 12) of preinfarction angina. HRV was assessed on 24-h Holter electrocardiograms recorded on day 3. Peak creatine kinase activity was significantly lower in group A than in group B (2,747+/-1,939 vs 4,891+/-2,639 IU/L, p<0.05). The SD of all RR intervals and ultra-low frequency, very low frequency, and low frequency powers was significantly less reduced in group A than in group B (86+/-24 vs 64+/-22 ms, p<0.05; 2,098+/-1,462 vs 867+/-502 ms2, p<0.01; 1,430+/-1,042 vs 546+/-344ms2, p<0.01; and 354+/-272 vs 186+/-136ms2, p<0.05; respectively). High frequency power, low frequency/high frequency, and pNN50 did not differ significantly between the 2 groups. In conclusion, preinfarction angina has a favorable influence on HRV in the early phase of anterior wall AMI.