RESUMO
OBJECTIVE: To determine the effect of uncomplicated malaria on platelet count. PATIENTS AND METHODS: Adult Nigerians (residing in the Lagos metropolis) who were diagnosed as having uncomplicated malaria were treated with a standard regime of chloroquine. Platelet counts were obtained before treatment, Day 0, and again on day 14 when parasitaemia had been cleared in the patients. There were 40 (21 males, 19 females) patients enrolled for the study. Their ages ranged from 15 years to 56 years with a mean +/- SEM of 27. 4 +/- 1.8 years. 28 (14 males, 14 females) patients had both day 0 and 14 platelet counts. RESULTS: The malaria parasite counts ranged from 1020 /mm(3) to 72,000 /mm(3) at day 0 with a mean +/-SEM of 15,638.0 +/- 3,727.0/mm(3) and zero on day 14. The mean platelet count on day 0 was 137.0 +/- 58.4x 10(9)/L while the day 14 mean platelet count was 234.0 +/- 96.9 x 10(9)/L. Comparison of mean platelet counts on day 0 with those on day 14 showed a highly statistically significant difference (p < 0.001). The degree of malaria parasitaemia was not significantly related to the level of platelet count. Transient thrombocytopenia is very common in uncomplicated malaria in semi -immune adults. The mechanism, aetiology, and clinical relevance of the phenomenon deserve further studies.
Assuntos
Malária/sangue , Contagem de Plaquetas , Adolescente , Adulto , Feminino , Humanos , Malária/complicações , Malária/parasitologia , Masculino , Pessoa de Meia-Idade , Nigéria/epidemiologia , Parasitemia/sangue , Trombocitopenia/epidemiologia , Trombocitopenia/etiologiaRESUMO
Progressive loss of virulence for goat kids was noticed when peste des petits ruminants (PPR) virus was passaged in Vero cells. While goats inoculated with the 60th passage suffered from the clinical PPR disease and mortality, goats inoculated with the 80th passage did not show any sign of the disease. If the progressive loss of virulence of the virus with passage continues, it will not be long before a homologous PPR vaccine will be obtained at the National Veterinary Institute, Vom.
Assuntos
Doenças das Cabras/microbiologia , Vírus da Peste Bovina/patogenicidade , Doenças dos Ovinos/microbiologia , Animais , Cabras , Nigéria , Vírus da Peste Bovina/fisiologia , Ovinos , Vacinas Virais , VirulênciaAssuntos
Doenças dos Bovinos/epidemiologia , Surtos de Doenças/veterinária , Doença Nodular Cutânea/epidemiologia , Animais , Bovinos , Doenças dos Bovinos/diagnóstico , Feminino , Doença Nodular Cutânea/diagnóstico , Vírus da Doença Nodular Cutânea/isolamento & purificação , Nigéria , Pele/microbiologiaRESUMO
A serological survey for egg drop syndrome 76 (EDS 76) virus, using the haemagglutination inhibition test, was conducted on commercial poultry flocks in Nigeria. Antibody was detected in layers on most of the farms. EDS 76 poses a potential threat to the Nigerian poultry industry and possible means of prevention and control are discussed.
Assuntos
Anticorpos Antivirais/análise , Doenças das Aves Domésticas/imunologia , Viroses/veterinária , Animais , Ovos , Feminino , Aves Domésticas , Síndrome , Viroses/imunologiaRESUMO
Four isolates of peste des petits ruminants virus were obtained from sick Nigerian sheep and goats. One was identical antigenically with the prototype Senegalese strain. A cross relationship was found between peste des petits ruminants virus and rinderpest virus based on neutralisation in vitro.
