RESUMO
Intrasplenic pressure changes versus ova count in stool of schistosomal portal hypertension in cases of bilharzial hepatic fibrosis were studied before and after 40 mg/kg body weight praziquantel therapy. Praziquantel acts on the vascular level in which it decreases the portal hypertension caused by bilharziasis as detected by decreased size of portal and splenic veins diameter as well as a significant decrease of portal pressure by the decrease of intrasplenic pressure (P less than 0.05). On the other hand, praziquantel decrease bilharzial stool egg count after 3 months of therapy (P less than 0.05).
Assuntos
Hipertensão Portal/etiologia , Praziquantel/uso terapêutico , Esquistossomose mansoni/complicações , Fezes/parasitologia , Hepatomegalia , Humanos , Contagem de Ovos de Parasitas , Esquistossomose mansoni/tratamento farmacológico , EsplenomegaliaRESUMO
Serum immunoglobulin, secretory IgA in stools and leucocyte migration inhibition test were done for 75 patients suffering from bilharzial and amoebic dysentery as well as 20 normal controls. Sigmoidoscopic examination with immunofluorescent staining of colonic biopsy was done in patients with bilharzial dysentery. Humoral immune response increased significantly as detected by significant increase in serum IgG and IgM. Secretory IgA decreased significantly in bilharzial cases leucocyte migration inhibition test decreased significantly as well as plasma cells secreting IgA. This change in systemic and local immune response may predispose to infection or occur secondary to the disease.
Assuntos
Disenteria Amebiana/imunologia , Esquistossomose mansoni/imunologia , Inibição de Migração Celular , Disenteria Amebiana/complicações , Disenteria Amebiana/patologia , Humanos , Imunoglobulina A Secretora/análise , Imunoglobulinas/análise , Esquistossomose mansoni/complicações , Esquistossomose mansoni/patologiaRESUMO
Fifty patients suffering from diarrhea were subjected together with a control group of 20 normal subjects to full clinical examination, stool analysis for parasites and bacteriological examination to identify pathogenic bacteria. Fecal alpha-1-antitrypsin, fecal Na+ and K+ and serum albumin were also estimated. The results showed a significant increase in the fecal alpha-1-antitrypsin and fecal electrolytes in all cases of diarrhea except the simple intestinal bilharzial cases, in which the fecal alpha 1-antitrypsin showed an inverse proportionality with fecal electrolytes. The serum albumin showed a negative correlation with fecal alpha-1 antitrypsin, however, serum albumin cannot be taken as a parameter for protein loosing enteropathy.
