RESUMO
Determination of Ag nanoparticles impact on microorganisms causative agents of purulent-inflammatory processes was carried out and it was stated that the greatest significance of growth inhibition zone was found in Staphylococcus aureus and Streptococcus pyogenes with sample length from 1 to 6 mm and Escherichia coli with 5-6 mm sample length. The investigated strains in an amount 104 - 106 CFU/ml were sensitive to Ðg nanoparticles activity, but at concentration 108 CFU/ml and more all strains were found persistent to samples of various length. The ability to form biofilms with planktonic cells of microorganisms under Ag nanoparticles activity sufficiently reduced from 3.4 (Candida albicans) to 5.5 (Klebsiella pneumonia) in investigated strains. The disorganization of daily biofilms was found in determining of Ag nanoparticles impact on formed biofilms of microorganisms.
Assuntos
Biofilmes , Nanopartículas Metálicas , Staphylococcus aureus , Antibacterianos , Biofilmes/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Prata , Staphylococcus aureus/efeitos dos fármacosRESUMO
Clinical effectiveness of metabolic support in surgical treatment of patients, suffering stenotic affection of carotid arteries, was estimated. Neoton intraoperative injection inside internal carotid artery have promoted improvement of metabolism in ischemized brain tissues, reduction of metabolic acidosis severity, and preservation of normal bioelectrical activity of the brain. Expediency of prolongation of clinical investigation for intraoperative prophylaxis of reperfusional brain tissue damage, while surgical treatment of patients, suffering stenotic affection of carotid arteries, using metabolic support, was discussed.
Assuntos
Isquemia Encefálica/tratamento farmacológico , Encéfalo/efeitos dos fármacos , Cardiotônicos/uso terapêutico , Artéria Carótida Interna/efeitos dos fármacos , Estenose das Carótidas/tratamento farmacológico , Fosfocreatina/uso terapêutico , Acidose/prevenção & controle , Encéfalo/irrigação sanguínea , Encéfalo/patologia , Encéfalo/cirurgia , Isquemia Encefálica/patologia , Isquemia Encefálica/cirurgia , Artéria Carótida Interna/patologia , Artéria Carótida Interna/cirurgia , Estenose das Carótidas/patologia , Estenose das Carótidas/cirurgia , Cateteres de Demora , Eletroencefalografia , Endarterectomia das Carótidas/métodos , Feminino , Humanos , Ácido Láctico/metabolismo , Masculino , Pessoa de Meia-IdadeRESUMO
As a results of the study of immune status of 75 patients with malignant skin melanoma, some signs of immunodeficiency with failure of cell and humoral reactions were revealed. The degree of quantitative and qualitative changes of immune system depended on clinical-morphological features of malignancy development.
Assuntos
Linfócitos B/imunologia , Linfócitos B/patologia , Vigilância Imunológica/imunologia , Melanoma/imunologia , Melanoma/patologia , Neoplasias Cutâneas/imunologia , Neoplasias Cutâneas/patologia , Linfócitos T/imunologia , Linfócitos T/patologia , Adulto , Linfócitos B/química , Cromatina/química , Feminino , Humanos , Imunoglobulinas/sangue , Imunofenotipagem , Masculino , Melanoma/sangue , Pessoa de Meia-Idade , Formação de Roseta , Neoplasias Cutâneas/sangue , Linfócitos T/química , Fator Tímico Circulante/análiseRESUMO
Twenty-one patients with injury to the brachial plexus suffered as the result of traumatic dislocation of the shoulder were examined and operated on with the use of microsurgical techniques. Traumatic changes of the nerve trunks, the development of a cicatricial-adhesive process around and within them lead to stable disorders of conduction which do not yield to nonoperative treatment. Stable traumatic changes revealed in the nerve trunks on EMG in the first 4-6 weeks after the trauma as well as the absence of an effect of nonoperative treatment within this period of time were indications for surgery. Despite the coarse macroscopic external changes found in the nerves of the brachial plexus they should not be resected without preliminary intratruncal inspection of the fasciculi with intraoperative electrodiagnosis.