RESUMO
The single exposition of 3- and 4-week mice in a dose 0.1 Gy resulted in depressing primary T-dependent humoral immune response. Unlike juvenile ones at adult 16-week animals the stimulation antibody-formation took place. As a result of the administration of immunomodulating drugs, thymogene and nucleinate of a sodium in irradiation mice of 3-week age was an augmentation of the number of antibody-producing cells relatively in 2 and 4 times. At the same time at irradiated in dose 0.1 Gy of adult mice thymogene abrogated the stimulating effect of radiation. It is suggested that the probable cause of the immunosuppressing effect of a small dose of radiation can be an inactivation of a radiosensitive subpopulation of helper cells or selective stimulation of the functional activity of neonatal suppressor cells.
Assuntos
Envelhecimento , Formação de Anticorpos/efeitos da radiação , Radiação Ionizante , Baço/efeitos da radiação , Envelhecimento/imunologia , Envelhecimento/efeitos da radiação , Animais , Animais Recém-Nascidos , Relação Dose-Resposta à Radiação , Masculino , Camundongos , Camundongos Endogâmicos , Baço/crescimento & desenvolvimento , Baço/imunologia , Fatores de TempoRESUMO
The nucleolar and extranucleolar RNA synthesis was studied in the mink blastocysts at different stages of embryonic diapause and during the periimplantation period using cytoradioautography. The data obtained suggest a differential and stage specific activity of the embryonic mRNA and rRNA synthesis during the period of delayed implantation.