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1.
Rev Sci Instrum ; 90(2): 023501, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30831775

RESUMO

In this paper, we present a method for numerical computation of collective Thomson scattering (CTS). We developed a forward model, eCTS, in the electrostatic approximation and benchmarked it against a full electromagnetic model. Differences between the electrostatic and the electromagnetic models are discussed. The sensitivity of the results to the ion temperature and the plasma composition is demonstrated. We integrated the model into the Bayesian data analysis framework Minerva and used it for the analysis of noisy synthetic data sets produced by a full electromagnetic model. It is shown that eCTS can be used for the inference of the bulk ion temperature. The model has been used to infer the bulk ion temperature from the first CTS measurements on Wendelstein 7-X.

2.
Rev Sci Instrum ; 90(1): 013503, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30709181

RESUMO

A Collective Thomson Scattering (CTS) diagnostic is installed at Wendelstein 7-X for ion temperature measurements in the plasma core. The diagnostic utilizes 140 GHz gyrotrons usually used for electron cyclotron resonance heating (ECRH) as a source of probing radiation. The CTS diagnostic uses a quasi-optical transmission line covering a distance of over 40 m. The transmission line is shared between the ECRH system and the CTS diagnostic. Here we elaborate on the design, installation, and alignment of the CTS diagnostic and present the first measurements at Wendelstein 7-X.

3.
Rev Sci Instrum ; 89(8): 083507, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30184679

RESUMO

Two methods for fast analysis of Collective Thomson Scattering (CTS) spectra are presented: Function Parametrization (FP) and feedforward Artificial Neural Networks (ANNs). At this time, a CTS diagnostic is being commissioned at the Wendelstein 7-X (W7-X) stellarator, with ion temperature measurements in the plasma core as its primary goal. A mapping was made from a database of simulated CTS spectra to the corresponding ion and electron temperatures (Ti and Te ). The mean absolute mapping errors are 4.2% and 9.9% relative to the corresponding Ti , for the ANN and FP, respectively, for spectra with Gaussian noise equivalent to 10% of the average of the spectral maxima in the database at 650 sampling points per GHz and within a limited parameter space. Although FP provides some insight into the information contents of the CTS spectra, ANNs provide a higher accuracy and noise robustness, are easier to implement, and are more adaptable to a larger parameter space. These properties make ANN mappings a promising all-round method for fast CTS data analysis. Addition of impurity concentrations to the current parameter space will enable fast bulk ion temperature measurements in the plasma core region of W7-X.

4.
Nanoscale ; 10(3): 1308-1321, 2018 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-29296980

RESUMO

We have produced an innovative, theranostic material based on FePt/SiO2/Au hybrid nanoparticles (NPs) for both, photo-thermal therapy and magnetic resonance imaging (MRI). Furthermore, a new synthesis approach, i.e., Au double seeding, for the preparation of Au nanoshells around the FePt/SiO2 cores, is proposed. The photo-thermal and the MRI response were first demonstrated on an aqueous suspension of hybrid FePt/SiO2/Au NPs. The cytotoxicity together with the internalization mechanism and the intracellular fate of the hybrid NPs were evaluated in vitro on a normal (NPU) and a half-differentiated cancerous cell line (RT4). The control samples as well as the normal cell line incubated with the NPs showed no significant temperature increase during the in vitro photo-thermal treatment (ΔT < 0.8 °C) and thus the cell viability remained high (∼90%). In contrast, due to the high NP uptake by the cancerous RT4 cell line, significant heating of the sample was observed (ΔT = 4 °C) and, consequently, after laser irradiation the cell viability dropped significantly to ∼60%. These results further confirm that the hybrid FePt/SiO2/Au NPs developed in the scope of this work were not only efficient but also highly selective photo-thermal agents. Furthermore, the improvement in the contrast and the easier distinction between the healthy and the cancerous tissues were clearly demonstrated with in vitro MRI experiments, proving that hybrid NPs have an excellent potential to be used as contrast agents.


Assuntos
Imageamento por Ressonância Magnética , Nanopartículas Metálicas , Dióxido de Silício , Nanomedicina Teranóstica , Animais , Linhagem Celular Tumoral , Sobrevivência Celular , Ouro , Temperatura Alta , Humanos , Ferro , Platina , Suínos
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