RESUMO
Rapid intravenous administration of D-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac diseases requires a comprehensive assessment of potential toxic effects of the drug in laboratory animals and in human beings. The potential clinical, behavioral, hematological, biochemical, gross pathological and histological toxic effects associated with the intravenous administration of D-ribose in rabbits for 28 days were evaluated in this study. Except for an increase in neutrophil percentage in male rabbits in the D-ribose-treated groups, there were no statistically significant toxic effects induced by daily intravenous administration of the drug in male and female rabbits. Results of this study suggest that D-ribose administered intravenously for 28 days in the rabbit exhibited no toxicity at 420 mg/kg.
Assuntos
Substâncias Protetoras/toxicidade , Ribose/toxicidade , Administração Intravenosa , Animais , Feminino , Contagem de Leucócitos , Masculino , Neutrófilos/citologia , Neutrófilos/efeitos dos fármacos , Substâncias Protetoras/administração & dosagem , Coelhos , Ribose/administração & dosagem , Testes de Toxicidade SubagudaRESUMO
Overweight and obesity is an escalating health problem in both developed and developing countries. This descriptive cross-sectional study aimed to determine the prevalence of overweight and obesity among adolescents aged 13-16 years in Irbid governorate, Jordan, and to compare the prevalence by sex, residential area and socioeconomic status. In a cluster random sample of 1355 school students the prevalence of overweight and obesity (body mass index > or = 85th percentile) was 24.4% (15.7% overweight and 8.7% obese) and was significantly higher among female students, students who lived in urban areas and those with working parents. This high prevalence of overweight is a serious concern for public health in Jordan.
Assuntos
Obesidade/epidemiologia , Sobrepeso/epidemiologia , Adolescente , Índice de Massa Corporal , Distribuição de Qui-Quadrado , Análise por Conglomerados , Estudos Transversais , Comportamento Alimentar , Feminino , Necessidades e Demandas de Serviços de Saúde , Humanos , Jordânia/epidemiologia , Masculino , Obesidade/diagnóstico , Obesidade/etiologia , Obesidade/prevenção & controle , Sobrepeso/diagnóstico , Sobrepeso/etiologia , Sobrepeso/prevenção & controle , Vigilância da População , Prevalência , Características de Residência/estatística & dados numéricos , Fatores de Risco , Comportamento Sedentário , Distribuição por Sexo , Classe Social , Estudantes/estatística & dados numéricosRESUMO
Overweight and obesity is an escalating health problem in both developed and developing countries. This descriptive cross-sectional study aimed to determine the prevalence of overweight and obesity among adolescents aged 13-16 years in Irbid governorate, Jordan, and to compare the prevalence by sex, residential area and socioeconomic status. In a cluster random sample of 1355 school students the prevalence of overweight and obesity [body mass index >/= 85th percentile] was 24.4% [15.7% overweight and 8.7% obese] and was significantly higher among female students, students who lived in urban areas and those with working parents. This high prevalence of overweight is a serious concern for public health in Jordan
