[Damaging effect of antibiotics on the structure of synaptonemal complexes of meiotic chromosome of mice]. / Povrezhdaiushchee deistvie antibiotikov na strukturu sinaptonemnykh kompleksov meioticheskikh khromosom myshi.

The structure of synaptonemal complexes (SCs) of chromosomes of mouse primary spermatocytes were studied using electron microscopy on days 1, 10, and 36 after the completion of per os administration of drugs belonging to three groups of antibiotics: tetracyclins, macrolides, and fluoroquinolones. The antibiotics were administered to mice during ten days. At the substages of early and middle pachytene, heteromorphic SC bivalents and fragments of chromosome-core elements were detected in spermatocytes at all times studied after the administration of the antibiotics of three groups. As cells passed through the period from early to middle pachytene, the number of cells containing heteromorphic SC bivalents and the fragments of chromosome cores gradually decreased, which could be an indication of selection of cells with chromosomal aberrations. A high level of associations between the X chromosome and autosome bivalents (including heteromorphic ones) also favors this suggestion. A gradual decrease in the number of chromosomal aberrations was detected, as time elapsed from the completion of antibiotics administration. The study of sperm obtained from epididymises of males did not reveal significant differences in both morphology and motility of sperm between males of the control and experimental groups.

[Immunomorphological changes in lichen ruber planus of the oral mucosa]. / Immunomorfologicheskie izmeneniia pri krasnom ploskom lishae slizistoi polosti rta.

Immunomorphologic examinations of 23 biopsy specimens of the buccal mucosa of patients with lichen ruber planus have revealed changes that confirm the hypothesis on the autoimmune nature of this disease. The basic cause of clinical manifestation of lichen planus is disordered microcirculatory system of the buccal mucosa, resultant from deposition of the immune complexes and fibrin in the vessel walls and lumen.

[Nail plate involvement in lichen ruber planus]. / Porazhenie nogtevykh plastinok pri krasnom ploskom lishae.

The authors review the literature data on the frequency of the nail plate involvement in lichen ruber planus and on the clinical features of this condition. Four patients suffering from lichen ruber planus with various manifestations of the nail plate involvement are described. The therapy efficacy depends on the severity of inflammation in the matrix unguis.

[Clinical characteristics of the erosive-ulcerative form of lichen ruber planus of the oral mucosa]. / Klinicheskie osobennosti érozivno-iazvennoi formy krasnogo ploskogo lishaia slizistoi rta.

Analysis of 650 case histories with the erosive ulcerative lichen ruber planus has revealed the specific features of the course of this condition: subjects aged 40-70 (90.5%) women more often than men (64%), suffer from this disease. Solitary foci (in 84%) are usually localized on the buccal mucosa. Concomitant diseases are very often: gastrointestinal conditions in 51% of patients, dental abnormalities in 34%. The disease should be differentiated from erosive leukoplakia, exfoliative cheilitis, etc. Tigason therapy has been found the most effective for this condition.