Electronic nicotine delivery system use and its relation to waterpipe smoking among youth in seven Arab countries.

OBJECTIVES: Electronic Nicotine Delivery System (ENDS) use and Waterpipe Tobacco Smoking (WTS) are reported to be a growing strain of tobacco epidemic among youth in the Arab world. Therefore, we aimed to: (1) estimate the regional prevalence of ENDS use among youth in 7 Arab countries and, (2) to explore the bidirectional relationship between ENDS use and WTS among Arab adolescents. METHODS: We analyzed data from the World Health Organization Global Youth Tobacco Survey (GYTS 2014-2018) of 18,536 schoolchildren aged 12-16 from Iraq, Mauritania, Morocco, Oman, Qatar, Tunisia, and Yemen. The weighted prevalence was calculated to generate nationally representative estimates. Adjusted multilevel logistic regression models were conducted to assess the association between ENDS use and WTS. RESULTS: The pooled weighted prevalence of ENDS use was 9.5%. Higher odds of ENDS use were significantly associated with WTS (AOR: 5.26, 95%CI: 4.28-6.46), smoking conventional cigarettes (AOR: 1.54, 95%CI: 1.23-1.94) and first tobacco use prior to the age of 12 (AOR: 1.40, 95%CI: 1.14-1.72). Females and children who were taught in school the dangers of tobacco had less odds of using ENDS. CONCLUSION: WTS was associated with increased odds of ENDS use by >5 folds, and vice versa. Tobacco consumption at age younger than 12 years was associated with higher odds of ENDS use, but less odds of WTS. Females and those who were taught in school the dangers of tobacco were less likely to report ENDS use.

Biotin-thiamine responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of cases in Kuwait with novel variants.

BACKGROUND: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare autosomal recessive neurometabolic disorder that is caused by biallelic pathogenic SLC19A3 variants and is characterized by subacute encephalopathy associated with confusion, convulsions, dysphagia, dysarthria, or other neurological manifestations. METHODS: A retrospective review of the data registry in Kuwait Medical Genetics Center for all cases diagnosed clinically and radiographically and confirmed genetically with BTBGD. RESULTS: Twenty one cases from 13 different families were diagnosed with BTBGD in Kuwait. Most cases (86%) presented with confusion, dystonia, convulsions, or dysarthria, while three individuals were diagnosed pre-symptomatically during familial targeted genetic screening. Symptoms resolved completely within 2-week of treatment in two-thirds of the symptomatic cases but progressed in six of them to a variety of severe symptoms including severe cogwheel rigidity, dystonia and quadriparesis due to delayed presentation and management. Neuroradiological findings of the symptomatic cases revealed bilateral central changes in the basal ganglia. Two novel homozygous missense SLC19A3 variants were detected in a Kuwaiti and a Jordanian individuals, in addition to the previously reported Saudi founder homozygous variant, c.1264A > G; p.(Thr422Ala) in the remaining cases. Age of diagnosis ranged from newborn to 32 years, with a median age of 2-3 years. All cases are still alive receiving high doses of biotin and thiamine. CONCLUSION: This is the first study reporting the phenotypic and genotypic spectrum of 21 individuals with BTBGD in Kuwait and describing two novel SLC19A3 variants. BTBGD is a treatable neurometabolic disease that requires early recognition and treatment initiation. This study highlights the importance of performing targeted molecular testing of the founder variant in patients presenting with acute encephalopathy in the region.

Risk factors associated with gestational diabetes mellitus: The role of pregnancy-induced hypertension and physical inactivity.

BACKGROUND: Gestational diabetes mellitus (GDM) causes serious complications affecting the mother and fetus. Physical activity (PA) during pregnancy has positive effects on the mother and fetus. The objectives of this study were to assess GMD prevalence in Kuwait, identify its risk factors, and to evaluate its association with PA. METHODS: A cross-sectional study was conducted among a randomly selected 653 post-partum women from all public maternal centers and five private centers. An anonymous self-administered questionnaire was used to collect participants' socio-demographic data, medical and obstetric history. Pregnancy Physical Activity Questionnaire (PPAQ) was used to assess PA level. RESULTS: Participants' mean age was 30.1 ± 5.3. GMD was diagnosed among 14.1% (95% CI: 11.6-17.0) of participants. Binary logistic regression revealed that poor income, having 2 + chronic diseases, past history of GDM, hypothyroidism, high systolic or diastolic blood pressure during pregnancy were independently correlated with developing GDM. For physical activity, the overall means of PPAQ total and sub-scores were below average and only PPAQ sub-score -Vigorous Intensity Activity- was significantly higher amid women without GMD than those with. However, PPAQ mean scores showed significant positive correlation with women's pre-pregnancy BMI and birth weight; and a significant negative association with gestational systolic and diastolic blood pressure. CONCLUSIONS: GDM prevalence is relatively high in Kuwait, notably amid expatriates. Pregnancy-induced hypertension along with social and pre-pregnancy medical conditions correlated with developing GDM. PA helped mitigated pregnancy blood pressure, and fetal birth weight. Promoting additional medical monitoring and PA during pregnancy might aid reduce the prevalence of GDM.